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v3.22.4

Consolidated Statements of Cash Flows - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Cash Flows from Operating Activities |  |  |
Net income | $ 6,244.8 | $ 5,581.7 | $ 6,193.7
Adjustments to Reconcile Net Income to Cash Flows from Operating Activities: |  |  |
Depreciation and amortization | 1,522.5 | 1,547.6 | 1,323.9
Debt extinguishment loss (Note 11) | 0.0 | 405.2 | 0.0
Change in deferred income taxes | (2,185.2) | (802.3) | (134.5)
Stock-based compensation expense | 371.1 | 342.8 | 308.1
Net investment (gains) losses | 420.0 | (178.0) | (1,438.5)
Acquired in-process research and development and development milestones (Note 3) | 420.9 | 874.9 | 660.4
Other non-cash operating activities, net | 304.8 | 511.4 | 333.9
Other changes in operating assets and liabilities, net of acquisitions and divestitures: |  |  |
Receivables—(increase) decrease | (299.6) | (1,278.3) | (1,350.2)
Inventories—(increase) decrease | (599.7) | (235.9) | (533.4)
Other assets—(increase) decrease | (793.5) | 1,515.4 | (457.1)
Income taxes payable—increase (decrease) | 346.6 | (359.7) | 322.0
Accounts payable and other liabilities—increase (decrease) | 1,331.7 | (664.1) | 1,271.3
Net Cash Provided by Operating Activities | 7,084.4 | 7,260.7 | 6,499.6
Cash Flows from Investing Activities |  |  |
Purchases of property and equipment | (1,854.3) | (1,309.8) | (1,387.9)
Proceeds from sales and maturities of short-term investments | 121.4 | 47.4 | 129.7
Purchases of short-term investments | (107.4) | (83.5) | (11.4)
Proceeds from sales of noncurrent investments | 342.2 | 800.0 | 757.1
Purchases of noncurrent investments | (600.2) | (929.9) | (358.7)
Purchases of in-process research and development | (629.7) | (563.4) | (641.2)
Cash paid for acquisitions, net of cash acquired (Note 3) | (327.2) | (747.4) | (849.3)
Other investing activities, net | (206.4) | 24.3 | 102.8
Net Cash Used for Investing Activities | (3,261.6) | (2,762.3) | (2,258.9)
Cash Flows from Financing Activities |  |  |
Dividends paid | (3,535.8) | (3,086.8) | (2,687.1)
Net change in short-term borrowings | 1,498.0 | (4.0) | (1,494.2)
Proceeds from issuance of long-term debt | 0.0 | 2,410.8 | 2,062.3
Repayments of long-term debt | (1,560.0) | (1,905.4) | (276.5)
Purchases of common stock | (1,500.0) | (1,250.0) | (500.0)
Other financing activities, net | (308.9) | (295.9) | (241.6)
Net Cash Used for Financing Activities | (5,406.7) | (4,131.3) | (3,137.1)
Effect of exchange rate changes on cash and cash equivalents | (167.6) | (205.7) | 216.0
Net increase (decrease) in cash and cash equivalents | (1,751.5) | 161.4 | 1,319.6
Cash and cash equivalents at beginning of year | 3,818.5 | 3,657.1 | 2,337.5
Cash and Cash Equivalents at End of Year | $ 2,067.0 | $ 3,818.5 | $ 3,657.1

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