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Revenue (Summary of Revenue Recognized) (Details) - USD ($)
$ in Millions
3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Disaggregation of Revenue [Line Items]    
Revenue $ 6,960.0 $ 7,810.0
Net product revenue    
Disaggregation of Revenue [Line Items]    
Revenue 6,238.2 7,132.9
Collaboration and other revenue    
Disaggregation of Revenue [Line Items]    
Revenue 721.8 677.1
Collaboration and other revenue associated with prior period transfers of intellectual property    
Disaggregation of Revenue [Line Items]    
Revenue $ 25.1 $ 53.2