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Collaborations and Other Arrangements - Narrative (Details) - USD ($) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Jul. 31, 2023 | Jun. 30, 2023 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenue |  |  | $ 45,042,700,000 | $ 34,124,100,000 | $ 28,541,400,000
Proceeds from sale of product rights |  |  | 601,300,000 | 1,604,300,000 | 95,800,000
Disposal Group, Disposed of by Sale, Not Discontinued Operations | Olanzapine Portfolio |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Proceeds from sale of product rights | $ 1,050,000,000.00 |  |  |  |
Consideration received |  |  | 305,000,000 |  |
Revenue recognized |  |  |  | 1,450,000,000 |
Disposal Group, Disposed of by Sale, Not Discontinued Operations | Baqsimi |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Proceeds from sale of product rights |  | $ 500,000,000 |  |  |
Consideration received |  |  | 125,000,000 |  |
Milestone payment received |  |  | 450,000,000 |  |
Revenue recognized |  |  |  | 579,000,000 |
Olumiant |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenue |  |  | $ 957,400,000 | 922,600,000 | 830,500,000
Olumiant | Royalty Payments Received |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Collaborative arrangement, rights and obligations percent (up to) |  |  | 20.00% |  |
Ebglyss | Milestone Payments, Sales-based |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Potential achievements |  |  | $ 1,250,000,000 |  |
Ebglyss | Milestone Payments, Sales-based | Roche |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Potential achievements |  |  | 1,030,000,000.00 |  |
Orforglipron | Milestone Payments, Development and Regulatory | Chugai |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Potential achievements |  |  | 140,000,000.0 |  |
Orforglipron | Milestone Payments, Sales-based | Chugai |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Potential achievements |  |  | 250,000,000.0 |  |
COVID-19 Antibodies |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenue |  |  | 0 | 0 | 2,020,000,000.00
Jardiance |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenue |  |  | 3,340,900,000 | $ 2,744,700,000 | $ 2,066,000,000
Jardiance | One Time Payment Received |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenue |  |  | $ 300,000,000 |  |

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