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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Millions
12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Income Statement [Abstract]      
Revenue (Note 2) $ 45,042.7 $ 34,124.1 $ 28,541.4
Costs, expenses, and other:      
Cost of sales 8,418.3 7,082.2 6,629.8
Research and development 10,990.6 9,313.4 7,190.8
Marketing, selling, and administrative 8,593.8 7,403.1 6,440.4
Acquired in-process research and development 3,280.4 3,799.8 908.5
Asset impairment, restructuring, and other special charges (Note 5) 860.6 67.7 244.6
Other—net, (income) expense (Note 18) 218.6 (96.7) 320.9
Costs, expenses, and other 32,362.3 27,569.5 21,735.0
Income before income taxes 12,680.4 6,554.6 6,806.4
Income taxes (Note 14) 2,090.4 1,314.2 561.6
Net income $ 10,590.0 $ 5,240.4 $ 6,244.8
Earnings per share:      
Basic (in dollars per share) $ 11.76 $ 5.82 $ 6.93
Diluted (in dollars per share) $ 11.71 $ 5.80 $ 6.90
Shares used in calculation of earnings per share:      
Basic (in shares) 900,605 900,181 901,736
Diluted (in shares) 904,059 903,284 904,619