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Collaborations and Other Arrangements - Narrative (Details) - USD ($)	1 Months Ended		12 Months Ended
	Jul. 31, 2023	Jun. 30, 2023	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue			$ 45,042,700,000	$ 34,124,100,000	$ 28,541,400,000
Proceeds from sale of product rights			601,300,000	1,604,300,000	95,800,000
Disposal Group, Disposed of by Sale, Not Discontinued Operations | Olanzapine Portfolio
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Proceeds from sale of product rights	$ 1,050,000,000.00
Consideration received			305,000,000
Revenue recognized				1,450,000,000
Disposal Group, Disposed of by Sale, Not Discontinued Operations | Baqsimi
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Proceeds from sale of product rights		$ 500,000,000
Consideration received			125,000,000
Milestone payment received			450,000,000
Revenue recognized				579,000,000
Olumiant
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue			$ 957,400,000	922,600,000	830,500,000
Olumiant | Royalty Payments Received
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative arrangement, rights and obligations percent (up to)			20.00%
Ebglyss | Milestone Payments, Sales-based
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential achievements			$ 1,250,000,000
Ebglyss | Milestone Payments, Sales-based | Roche
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential achievements			1,030,000,000.00
Orforglipron | Milestone Payments, Development and Regulatory | Chugai
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential achievements			140,000,000.0
Orforglipron | Milestone Payments, Sales-based | Chugai
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential achievements			250,000,000.0
COVID-19 Antibodies
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue			0	0	2,020,000,000.00
Jardiance
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue			3,340,900,000	$ 2,744,700,000	$ 2,066,000,000
Jardiance | One Time Payment Received
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue			$ 300,000,000

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