<SEC-DOCUMENT>0000316011-25-000041.txt : 20251030
<SEC-HEADER>0000316011-25-000041.hdr.sgml : 20251030
<ACCEPTANCE-DATETIME>20251030173425
ACCESSION NUMBER:		0000316011-25-000041
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251030
DATE AS OF CHANGE:		20251030

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ELI LILLY & Co
		CENTRAL INDEX KEY:			0000059478
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				350470950
		STATE OF INCORPORATION:			IN
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-17885
		FILM NUMBER:		251437247

	BUSINESS ADDRESS:	
		STREET 1:		LILLY CORPORATE CTR
		STREET 2:		DROP CODE 1094
		CITY:			INDIANAPOLIS
		STATE:			IN
		ZIP:			46285
		BUSINESS PHONE:		3172762000

	MAIL ADDRESS:	
		STREET 1:		LILLY CORPORATE CENTER
		STREET 2:		DROP CODE 1094
		CITY:			INDIANAPOLIS
		STATE:			IN
		ZIP:			46285

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LILLY ELI & CO
		DATE OF NAME CHANGE:	19941024

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LILLY ENDOWMENT INC
		CENTRAL INDEX KEY:			0000316011
		ORGANIZATION NAME:           	
		EIN:				350868122
		STATE OF INCORPORATION:			IN
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		2801 NORTH MERIDIAN STREET
		CITY:			INDIANANAPOLIS
		STATE:			IN
		ZIP:			46208
		BUSINESS PHONE:		3179245471

	MAIL ADDRESS:	
		STREET 1:		2801 NORTH MERIDIAN ST
		CITY:			INDIANAPOLIS
		STATE:			IN
		ZIP:			46208
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
		<previousAccessionNumber>0000911916-94-000024</previousAccessionNumber>
	    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0000316011</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>





    </filerInfo>
  </headerData>

  <formData>
    <coverPageHeader>
		<amendmentNo>43</amendmentNo>
	      <securitiesClassTitle>Common Stock, Without Par Value</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>09/30/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0000059478</issuerCik>        <issuerName>ELI LILLY AND COMPANY</issuerName>        <issuerCusip>532457108</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>LILLY CORPORATE CTR</com:street1>
          <com:street2>DROP CODE 1094</com:street2>          <com:city>INDIANAPOLIS</com:city>
          <com:stateOrCountry>IN</com:stateOrCountry>
          <com:zipCode>46285</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>

	        <designateRulesPursuantThisScheduleFiled>
	           <designateRulePursuantThisScheduleFiled>Rule 13d-1(d)</designateRulePursuantThisScheduleFiled>
						      </designateRulesPursuantThisScheduleFiled>

    </coverPageHeader>

	    <coverPageHeaderReportingPersonDetails>




    <reportingPersonName>LILLY ENDOWMENT, INC.</reportingPersonName>



		 <citizenshipOrOrganization>IN</citizenshipOrOrganization>

      <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>95492993.00</soleVotingPower>
                          <sharedVotingPower>0.00</sharedVotingPower>
                          <soleDispositivePower>95492993.00</soleDispositivePower>
                         <sharedDispositivePower>0.00</sharedDispositivePower>
             </reportingPersonBeneficiallyOwnedNumberOfShares>

              <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>95492993.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>


     	    <classPercent>10.1</classPercent>









	        <typeOfReportingPerson>CO</typeOfReportingPerson>





	  <comments>The percentage of class represented is based on 946,456,759 shares of common stock outstanding as of August 4, 2025 (the most recent date for which such information is publicly available), as reported in the Issuer's Form 10-Q for the period ended June 30, 2025.

This information is provided as of September 30, 2025.</comments>

    </coverPageHeaderReportingPersonDetails>

    <items>
      <item1>
        <issuerName>ELI LILLY AND COMPANY</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>LILLY CORPORATE CTR, DROP CODE 1094, INDIANAPOLIS, IN, 46285.</issuerPrincipalExecutiveOfficeAddress>
      </item1>

      <item2>
        <filingPersonName>This statement is filed by Lilly Endowment, Inc., a not for profit corporation organized under the laws of the State of Indiana.  Lilly Endowment, Inc. is an organization described in Section 501(c)(3) of the Internal Revenue Code of 1986, as amended (the Code), and is a private foundation under Section 509(a) of the Code.

</filingPersonName>        <principalBusinessOfficeOrResidenceAddress>The address of the principal business office of Lilly Endowment, Inc. is 2801 North Meridian Street, Indianapolis, IN 46208.</principalBusinessOfficeOrResidenceAddress>        <citizenship>Indiana</citizenship>      </item2>

        <item3>
		        <notApplicableFlag>Y</notApplicableFlag>

      </item3>



    <item4>
    <amountBeneficiallyOwned>95,492,993 shares as of September 30, 2025 - None of such shares are deemed to be beneficially owned by reason of the possession of Lilly Endowment, Inc. of a right to acquire such shares.</amountBeneficiallyOwned>    <classPercent>10.1%</classPercent>
      <numberOfSharesPersonHas>
        <solePowerOrDirectToVote>95,492,993 shares</solePowerOrDirectToVote>
        <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
        <solePowerOrDirectToDispose>95,492,993 shares</solePowerOrDirectToDispose>
        <sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
      </numberOfSharesPersonHas>
    </item4>


        <item5>
	          <notApplicableFlag>Y</notApplicableFlag>


    </item5>


        <item6>
	  	  <notApplicableFlag>Y</notApplicableFlag>
		        </item6>


        <item7>
	  	  <notApplicableFlag>Y</notApplicableFlag>


    </item7>


          <item8>
                <notApplicableFlag>Y</notApplicableFlag>

              </item8>


            <item9>
                <notApplicableFlag>Y</notApplicableFlag>
                      </item9>


      <item10>
                    <notApplicableFlag>Y</notApplicableFlag>

      </item10>
    </items>


	    <signatureInformation>
      <reportingPersonName>LILLY ENDOWMENT, INC.</reportingPersonName>

      <signatureDetails>
        <signature>Diane M. Stenson</signature>
        <title>Vice President and Treasurer</title>
        <date>10/30/2025</date>
      </signatureDetails>

    </signatureInformation>



  </formData>

    </edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
