<SEC-DOCUMENT>0000904454-19-000071.txt : 20190122
<SEC-HEADER>0000904454-19-000071.hdr.sgml : 20190122
<ACCEPTANCE-DATETIME>20190122113402
ACCESSION NUMBER:		0000904454-19-000071
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20190122
DATE AS OF CHANGE:		20190122

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ADURO BIOTECH, INC.
		CENTRAL INDEX KEY:			0001435049
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-88812
		FILM NUMBER:		19534763

	BUSINESS ADDRESS:	
		STREET 1:		740 HEINZ AVENUE
		CITY:			BERKELEY
		STATE:			CA
		ZIP:			94710
		BUSINESS PHONE:		510-848-4400

	MAIL ADDRESS:	
		STREET 1:		740 HEINZ AVENUE
		CITY:			BERKELEY
		STATE:			CA
		ZIP:			94710

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADURO BIOTECH
		DATE OF NAME CHANGE:	20080514

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			JOHNSON & JOHNSON
		CENTRAL INDEX KEY:			0000200406
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				221024240
		STATE OF INCORPORATION:			NJ
		FISCAL YEAR END:			0101

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		ONE JOHNSON & JOHNSON PLZ
		CITY:			NEW BRUNSWICK
		STATE:			NJ
		ZIP:			08933
		BUSINESS PHONE:		732-524-2455

	MAIL ADDRESS:	
		STREET 1:		ONE JOHNSON & JOHNSON PLZ
		CITY:			NEW BRUNSWICK
		STATE:			NJ
		ZIP:			08933
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>s13ga_012119-adurobio.htm
<DESCRIPTION>SCHEDULE 13G-A FOR ADURO BIOTECH, INC. BY JOHNSON & JOHNSON
<TEXT>
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            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">SECURITIES AND EXCHANGE COMMISSION</div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Washington, D.C. 20549</font></div>
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          <td style="width: 100%; vertical-align: top;">&#160;</td>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">SCHEDULE 13G</font></div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(Rule 13d-102)</font></div>
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          <td style="width: 100%; vertical-align: top;">&#160;</td>
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          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT</font></div>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">TO RULES 13d-1(b),(c) AND (d) AND AMENDMENTS THERETO FILED</font></div>
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          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">PURSUANT TO RULE 13d-2(b)</font></div>
          </td>
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          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(Amendment No. 1)<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup></font></div>
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          <td style="width: 100%; vertical-align: top;">&#160;</td>
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          <td style="width: 100%; vertical-align: top;">&#160;</td>
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          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Aduro Biotech, Inc.</font></div>
          </td>
        </tr>
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          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(Name of Issuer)</font></div>
          </td>
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          <td style="width: 100%; vertical-align: top;">&#160;</td>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Common Stock, $.0001 par value</font></div>
          </td>
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            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(Title of Class of Securities)</font></div>
          </td>
        </tr>
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          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
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          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">00739L101</font></div>
          </td>
        </tr>
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          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(CUSIP Number)</font></div>
          </td>
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          <td style="width: 100%; vertical-align: top;">&#160;</td>
        </tr>
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          <td style="width: 100%; vertical-align: top;">&#160;</td>
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          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">December 31, 2018</font></div>
          </td>
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          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(Date of Event Which Requires Filing of this Statement)</font></div>
          </td>
        </tr>

    </table>
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    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Check the appropriate box to designate the rule pursuant to which this Schedule is filed:</font></div>
    <div><br>
    </div>
    <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">[&#160;&#160; ] Rule 13d-1(b)</font></div>
    <div><br>
    </div>
    <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">[&#160;&#160; ] Rule 13d-1(c)</font></div>
    <div><br>
    </div>
    <div style="text-align: left; text-indent: 36pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">[X] Rule 13d-1(d)</font></div>
    <br>
    <br>
    <hr noshade="noshade" align="left" style="text-align: left; background-color: #000000; border: 0px; height: 1px; width: 2in; margin-left: 0pt; margin-right: auto; color: #000000;">
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup>&#160;<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">The remainder of this cover page shall be filled out
          for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.&#160; The information required
          on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section of the Act but shall be subject to all other
          provisions of the Act.</font></font></div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
        </font></font></div>
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        </font></font></div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
        </font></font></div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
        </font></font></div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">1</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
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    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
        </font></font></div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
        </font></font></div>
    <font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> CUSIP No. </font><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;,Times,serif; font-weight: normal;">00739L101</font>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
        </font></font></div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="zc02581ff2e084764a207b77eefb4e4da" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;">

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          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">1.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">NAME OF REPORTING PERSON</font></div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON</font></div>
            <div>&#160;</div>
            <div style="text-align: left; margin-left: 44.1pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Johnson &amp; Johnson</font></div>
            <div style="text-align: left; margin-left: 44.1pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">EIN:&#160; 22-1024240</font></div>
            <div>&#160;</div>
          </td>
        </tr>
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          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">2.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</font></div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
          <td style="width: 18%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: right; margin-right: 13.5pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(a)</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width:
                36pt">&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">[&#160;&#160; ]</font></div>
            <div style="text-align: right; margin-right: 13.5pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(b)</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width:
                36pt">&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">[&#160;&#160; ]</font></div>
          </td>
        </tr>
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          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">3.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">SEC USE ONLY</font></div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div>&#160;</div>
          </td>
        </tr>
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          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">4.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">CITIZENSHIP OR PLACE OF ORGANIZATION</font></div>
            <div style="text-align: left; margin-left: 44.1pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left; margin-left: 44.1pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">New Jersey</font></div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" rowspan="4" colspan="2">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">NUMBER OF<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>SHARES<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>BENEFICIALLY<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>OWNED BY<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>EACH<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>REPORTING<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>PERSON<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>WITH</font></div>
          </td>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">5.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">SOLE VOTING POWER </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">-0-</font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">6.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">SHARED VOTING POWER </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">3,906,207*</font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">7.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">SOLE DISPOSITIVE POWER </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">-0-</font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">8.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">SHARED DISPOSITIVE POWER </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">3,906,207*</font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">9.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">3,906,207*</font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">10.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div style="text-align: left; margin-right: 75.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</font></div>
            <div style="text-align: left; margin-right: 75.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
          <td style="width: 18%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); text-align: right;">
            <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;,Times,serif;">[&#160;&#160; ]</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">11.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">4.9%**</font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">12.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">TYPE OF REPORTING PERSON </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">CO<br>
                <br>
              </font></div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">* As of December 31, 2018.</font></div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">** Based on 79,404,084 shares of Common Stock outstanding as of October 26, 2018, as reported in the Issuer&#8217;s Report on Form 10-Q for the period
        ended September 30, 2018 filed with the Securities and Exchange Commission on October 30, 2018.</font></div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </font></div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </font></div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </font></div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </font></div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </font></div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">2</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
      </font></div>
  </div>
  <div><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
    </font></div>
  <div><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> CUSIP No. </font><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;,Times,serif; font-weight: normal;">00739L101</font></div>
  <div><br>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="z9c1f1112f6b346b79309a35b4c53e1d3" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%;">

        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">1.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">NAME OF REPORTING PERSON</font></div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON</font></div>
            <div>&#160;</div>
            <div style="text-align: left; margin-left: 44.1pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Johnson &amp; Johnson Innovation-JJDC, Inc.</font></div>
            <div style="text-align: left; margin-left: 44.1pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">EIN:&#160; 22-2007137</font></div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">2.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</font></div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
          <td style="width: 18%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: right; margin-right: 13.5pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(a)</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width:
                36pt">&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">[&#160;&#160; ]</font></div>
            <div style="text-align: right; margin-right: 13.5pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(b)</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width:
                36pt">&#160;</font><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">[&#160;&#160; ]</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">3.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">SEC USE ONLY</font></div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">4.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">CITIZENSHIP OR PLACE OF ORGANIZATION</font></div>
            <div style="text-align: left; margin-left: 44.1pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left; margin-left: 44.1pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">New Jersey</font></div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" rowspan="4" colspan="2">
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">NUMBER OF<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>SHARES<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>BENEFICIALLY<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>OWNED BY<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>EACH<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>REPORTING<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>PERSON<font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><br>
                </font>WITH</font></div>
          </td>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">5.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">SOLE VOTING POWER </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">-0-</font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">6.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">SHARED VOTING POWER </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> </font>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">3,906,207*</font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">7.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">SOLE DISPOSITIVE POWER </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">-0-</font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">8.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">SHARED DISPOSITIVE POWER </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">3,906,207*</font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">9.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">3,906,207*</font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">10.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div style="text-align: left; margin-right: 75.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</font></div>
            <div style="text-align: left; margin-right: 75.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
          <td style="width: 18%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); text-align: right;">
            <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;,Times,serif;">[&#160;&#160; ]</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">11.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">4.9%**</font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">12.</font></div>
          </td>
          <td style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">TYPE OF REPORTING PERSON </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">CO</font></div>
            <div style="text-align: left; margin-left: 3.6pt;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> <br>
              </font></div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">* As of December 31, 2018.</font></div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">** Based on 79,404,084 shares of Common Stock outstanding as of October 26, 2018, as reported in the Issuer&#8217;s Report on Form 10-Q for the period
        ended September 30, 2018 filed with the Securities and Exchange Commission on October 30, 2018.</font></div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">3</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> CUSIP No. </font><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;,Times,serif; font-weight: normal;">00739L101</font></div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><u>AMENDMENT NO. 1 TO SCHEDULE 13G (FINAL
            AMENDMENT)</u></font></font></div>
    <div><br>
    </div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Reference is hereby made the statement on Schedule 13G filed with
          the Securities and Exchange Commission by the Reporting Persons with respect to the Common Stock of the Issuer on February 12, 2016&#160; (the &#8220;Schedule 13G&#8221;).&#160; Terms defined in the Schedule 13G are used herein as so defined.</font></font></div>
    <div><br>
    </div>
    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">The following items of the Schedule 13G are amended and restated to read in their entirety as follows:</font></div>
    <div><br>
    </div>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">ITEM 1(b)</font></div>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">ADDRESS OF ISSUER&#8217;S PRINCIPAL EXECUTIVE OFFICES:</font></div>
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          <td style="width: 0.09%; vertical-align: top;">&#160;</td>
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          <td style="width: 0.19%; vertical-align: top;">&#160;</td>
          <td style="width: 14.1%; vertical-align: top;">&#160;</td>
          <td style="width: 85.62%; vertical-align: top;">&#160;</td>
          <td style="width: 0.09%; vertical-align: top;">&#160;</td>
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          <td style="width: 0.19%; vertical-align: top;">&#160;</td>
          <td style="width: 14.1%; vertical-align: top;">&#160;</td>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">740 Heinz Avenue, Berkeley, CA 94710</font></div>
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          <td style="width: 0.09%; vertical-align: top;">&#160;</td>
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          <td style="width: 0.19%; vertical-align: top;">&#160;</td>
          <td style="width: 14.1%; vertical-align: top;">&#160;</td>
          <td style="width: 85.62%; vertical-align: top;">&#160;</td>
          <td style="width: 0.09%; vertical-align: top;">&#160;</td>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">ITEM 2(b)</font></div>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">ADDRESS OF PRINCIPAL BUSINESS OFFICE:</font></div>
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          <td style="width: 14.29%; vertical-align: top;" colspan="2">&#160;</td>
          <td style="width: 85.71%; vertical-align: top;" colspan="2">&#160;</td>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">J&amp;J:&#160; One Johnson &amp; Johnson Plaza, New Brunswick, NJ 08933</font></div>
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">JJDC:&#160; 410 George Street, New Brunswick NJ 08901</font></div>
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          <td style="width: 14.29%; vertical-align: top;" colspan="2">&#160;</td>
          <td style="width: 85.71%; vertical-align: top;" colspan="2">&#160;</td>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">ITEM 4</font></div>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">(a) through (c)</font></div>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">The information set forth in the cover pages to this Amendment No. 1 to Schedule 13G is incorporated herein by reference thereto.</font></div>
            <div>&#160;</div>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">ITEM 5</font></div>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">If this statement is being filed to report the fact that the Reporting Persons have ceased to be beneficial owners of more than five
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            <div>&#160;</div>
            <div>&#160;</div>
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    <div><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"> CUSIP No. </font><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;,Times,serif; font-weight: normal;">00739L101</font></div>
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    <div style="text-align: center;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;"><u>SIGNATURE</u></font></font></div>
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    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">After reasonable inquiry and to the best of their knowledge and belief, the undersigned certify that the information set forth in this statement
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    <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Dated:&#160; January 22, 2019</font></div>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">JOHNSON &amp; JOHNSON</font></div>
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          <td style="width: 11.47%; vertical-align: top;">&#160;</td>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">/s/ Thomas Spellman III</font></div>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Name:</font></div>
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          <td style="width: 30.08%; vertical-align: top;">
            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Thomas Spellman III</font></div>
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          <td style="width: 11.47%; vertical-align: top;">&#160;</td>
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          <td style="width: 11.47%; vertical-align: top;">&#160;</td>
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          <td style="width: 49.06%; vertical-align: top;">&#160;</td>
          <td style="width: 6%; vertical-align: top;">&#160;</td>
          <td style="width: 30.08%; vertical-align: top;">&#160;</td>
          <td style="width: 11.47%; vertical-align: top;">&#160;</td>
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          <td style="width: 49.06%; vertical-align: top;">&#160;</td>
          <td style="width: 6%; vertical-align: top;">&#160;</td>
          <td style="width: 30.08%; vertical-align: top;">&#160;</td>
          <td style="width: 11.47%; vertical-align: top;">&#160;</td>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif; font-weight: bold;">JOHNSON &amp; JOHNSON INNOVATION-JJDC, INC.</font></div>
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          <td style="width: 11.47%; vertical-align: top;">&#160;</td>
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          <td style="width: 49.06%; vertical-align: top;">&#160;</td>
          <td style="width: 6%; vertical-align: top;">&#160;</td>
          <td style="width: 30.08%; vertical-align: top;">&#160;</td>
          <td style="width: 11.47%; vertical-align: top;">&#160;</td>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">/s/ Kevin Norman</font></div>
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          <td style="width: 11.47%; vertical-align: top;">&#160;</td>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Kevin Norman</font></div>
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          <td style="width: 11.47%; vertical-align: top;">&#160;</td>
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            <div style="text-align: left;"><font style="font-size: 10pt; font-family: 'Times New Roman', Times, serif;">Assistant Secretary</font></div>
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