<SEC-DOCUMENT>0000904454-23-000019.txt : 20230111
<SEC-HEADER>0000904454-23-000019.hdr.sgml : 20230111
<ACCEPTANCE-DATETIME>20230111130018
ACCESSION NUMBER:		0000904454-23-000019
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20230111
DATE AS OF CHANGE:		20230111

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Protagonist Therapeutics, Inc
		CENTRAL INDEX KEY:			0001377121
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				980505495
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-89601
		FILM NUMBER:		23523133

	BUSINESS ADDRESS:	
		STREET 1:		7707 GATEWAY BLVD., SUITE 140
		CITY:			NEWARK
		STATE:			CA
		ZIP:			94560-1160
		BUSINESS PHONE:		(510) 474-0170

	MAIL ADDRESS:	
		STREET 1:		7707 GATEWAY BLVD., SUITE 140
		CITY:			NEWARK
		STATE:			CA
		ZIP:			94560-1160

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Protagonist Therapeutics Inc
		DATE OF NAME CHANGE:	20130605

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Protagonist Inc
		DATE OF NAME CHANGE:	20061002

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			JOHNSON & JOHNSON
		CENTRAL INDEX KEY:			0000200406
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				221024240
		STATE OF INCORPORATION:			NJ
		FISCAL YEAR END:			0101

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		ONE JOHNSON & JOHNSON PLZ
		CITY:			NEW BRUNSWICK
		STATE:			NJ
		ZIP:			08933
		BUSINESS PHONE:		732-524-2455

	MAIL ADDRESS:	
		STREET 1:		ONE JOHNSON & JOHNSON PLZ
		CITY:			NEW BRUNSWICK
		STATE:			NJ
		ZIP:			08933
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>s13ga_123122-protagonthera.htm
<DESCRIPTION>SCHEDULE 13G/A FOR PROTAGONIST THERAPEUTICS, INC. ON BEHALF OF JOHNSON & JOHNSON.
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            <div style="text-align: center; font-size: 12pt;">SECURITIES AND EXCHANGE COMMISSION</div>
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            <div style="text-align: center; font-size: 12pt;">Washington, D.C. 20549</div>
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            <div style="text-align: center; font-size: 12pt;">SCHEDULE 13G</div>
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            <div style="text-align: center; font-size: 12pt;">(Rule 13d-102)</div>
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            <div style="text-align: center; font-size: 12pt;">INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT</div>
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            <div style="text-align: center; font-size: 12pt;">TO RULES 13d-1(b),(c) AND (d) AND AMENDMENTS THERETO FILED</div>
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          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; font-size: 12pt;">PURSUANT TO RULE 13d-2(b)</div>
            <div>&#160;</div>
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            <div style="text-align: center; font-size: 12pt;">(Amendment No. 2)<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup></div>
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            <div style="text-align: center; font-size: 12pt;">Protagonist Therapeutics, Inc.</div>
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            <div style="text-align: center; font-size: 12pt;">(Name of Issuer)</div>
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          <td style="width: 100%; vertical-align: top;">&#160;</td>
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            <div style="text-align: center; font-size: 12pt;">Common Stock, $.00001 par value</div>
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            <div style="text-align: center; font-size: 12pt;">(Title of Class of Securities)</div>
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          <td style="width: 100%; vertical-align: top;">&#160;</td>
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          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">74366E102</div>
          </td>
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            <div style="text-align: center; font-size: 12pt;">(CUSIP Number)</div>
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          <td style="width: 100%; vertical-align: top;">&#160;</td>
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          <td style="width: 100%; vertical-align: top;">&#160;</td>
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          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">December 31, 2022</div>
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            <div style="text-align: center; font-size: 12pt;">(Date of Event Which Requires Filing of this Statement)</div>
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    <div style="font-size: 12pt;">Check the appropriate box to designate the rule pursuant to which this Schedule is filed:</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; font-size: 12pt;">[&#160;&#160; ] Rule 13d-1(b)</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; font-size: 12pt;">[X] Rule 13d-1(c)</div>
    <div><br>
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    <div style="text-indent: 36pt; font-size: 12pt;">[&#160;&#160; ] Rule 13d-1(d)</div>
    <br>
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    <div style="text-indent: 36pt; font-size: 12pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup>&#160;<font style="font-size: 10pt;">The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and
        for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.&#160; The information required on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the
        Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act.</font></div>
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    <div>
      <div style="font-size: 12pt;">CUSIP No. 74366E102</div>
      <div style="font-size: 12pt;"> <br>
      </div>
      <div style="font-size: 12pt;"> <br>
      </div>
    </div>
    <table cellspacing="0" cellpadding="0" id="z61604b73ed14404789e61a34382a8d31" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">1.</div>
          </td>
          <td style="width: 94.17%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="4">
            <div style="font-size: 12pt;">NAME OF REPORTING PERSON</div>
            <div style="font-size: 12pt;">S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (VOLUNTARY)</div>
            <div>&#160;</div>
            <div style="margin-left: 44.1pt; font-size: 12pt;">Johnson &amp; Johnson</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
        </tr>
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          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">2.</div>
          </td>
          <td style="width: 74.25%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="3">
            <div style="font-size: 12pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
          </td>
          <td style="width: 19.92%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div><font style="font-size: 12pt;">(a)&#160;&#160;&#160;&#160; [&#160;&#160; ]</font></div>
            <div><font style="font-size: 12pt;">(b)&#160;&#160;&#160;&#160; [&#160;&#160; ]<br>
              </font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">3.</div>
          </td>
          <td style="width: 94.17%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="4">
            <div style="font-size: 12pt;">SEC USE ONLY</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">4.</div>
          </td>
          <td style="width: 94.17%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="4">
            <div style="font-size: 12pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="margin-left: 44.1pt; font-size: 12pt;">New Jersey</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 24.62%; vertical-align: top; border-bottom: #000000 2px solid;" rowspan="4" colspan="2">
            <div style="text-align: center; font-size: 12pt;">NUMBER OF<br>
              SHARES<br>
              BENEFICIALLY<br>
              OWNED BY<br>
              EACH<br>
              REPORTING<br>
              PERSON<br>
              WITH</div>
          </td>
          <td style="width: 5.64%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">5.</div>
          </td>
          <td style="width: 34.87%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div style="margin-left: 3.6pt;">SOLE VOTING POWER </div>
            <div style="margin-left: 3.6pt;"><br>
            </div>
          </td>
          <td style="width: 34.87%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">-0-</td>
        </tr>
        <tr>
          <td style="width: 18.8%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">6.</div>
          </td>
          <td style="width: 27.72%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div style="margin-left: 3.6pt;">SHARED VOTING POWER </div>
            <div style="margin-left: 3.6pt;"><br>
            </div>
          </td>
          <td style="width: 27.72%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">2,449,183</td>
        </tr>
        <tr>
          <td style="width: 18.8%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">7.</div>
          </td>
          <td style="width: 27.72%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div style="margin-left: 3.6pt;">SOLE DISPOSITIVE POWER </div>
            <div style="margin-left: 3.6pt;"><br>
            </div>
          </td>
          <td style="width: 27.72%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">-0-</td>
        </tr>
        <tr>
          <td style="width: 18.8%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">8.</div>
          </td>
          <td style="width: 27.72%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div style="margin-left: 3.6pt;">SHARED DISPOSITIVE POWER </div>
            <div style="margin-left: 3.6pt;"><br>
            </div>
          </td>
          <td style="width: 27.72%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">2,449,183</td>
        </tr>
        <tr>
          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">9.</div>
          </td>
          <td style="width: 47.08%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div style="font-size: 12pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED<br>
              BY EACH REPORTING PERSON <br>
            </div>
          </td>
          <td style="width: 47.08%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div>2,449,183</div>
            <div> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">10.</div>
          </td>
          <td style="width: 74.25%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="3">
            <div style="font-size: 12pt;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</div>
          </td>
          <td style="width: 19.92%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div>[ &#160; ]</div>
            <div> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">11.</div>
          </td>
          <td style="width: 47.08%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div style="font-size: 12pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</div>
          </td>
          <td style="width: 47.08%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div>4.98%</div>
            <div> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">12.</div>
          </td>
          <td style="width: 47.08%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div style="font-size: 12pt;">TYPE OF REPORTING PERSON <br>
            </div>
          </td>
          <td style="width: 47.08%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div>CO</div>
            <div> <br>
            </div>
          </td>
        </tr>

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    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">2</font></div>
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div>
      <div style="font-size: 12pt;">CUSIP No. 74366E102</div>
      <div style="font-size: 12pt;"> <br>
      </div>
      <div style="font-size: 12pt;"> <br>
      </div>
    </div>
    <table cellspacing="0" cellpadding="0" id="zf3f17b3e7e404a0d9813e985604c2347" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">1.</div>
          </td>
          <td style="width: 94.17%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="4">
            <div style="font-size: 12pt;">NAME OF REPORTING PERSON</div>
            <div style="font-size: 12pt;">S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (VOLUNTARY)</div>
            <div>&#160;</div>
            <div style="margin-left: 44.1pt; font-size: 12pt;">Johnson &amp; Johnson Innovation-JJDC, Inc.</div>
            <div>&#160;</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">2.</div>
          </td>
          <td style="width: 74.25%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="3">
            <div style="font-size: 12pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
          </td>
          <td style="width: 19.92%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div><font style="font-size: 12pt;">(a)&#160;&#160;&#160;&#160; [&#160;&#160; ]</font></div>
            <div><font style="font-size: 12pt;">(b)&#160;&#160;&#160;&#160; [&#160;&#160; ]</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">3.</div>
          </td>
          <td style="width: 94.17%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="4">
            <div style="font-size: 12pt;">SEC USE ONLY</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">4.</div>
          </td>
          <td style="width: 94.17%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="4">
            <div style="font-size: 12pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="margin-left: 44.1pt; font-size: 12pt;">New Jersey</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 24.62%; vertical-align: top; border-bottom: #000000 2px solid;" rowspan="4" colspan="2">
            <div style="text-align: center; font-size: 12pt;">NUMBER OF<br>
              SHARES<br>
              BENEFICIALLY<br>
              OWNED BY<br>
              EACH<br>
              REPORTING<br>
              PERSON<br>
              WITH</div>
          </td>
          <td style="width: 5.64%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">5.</div>
          </td>
          <td style="width: 34.87%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div style="margin-left: 3.6pt;">SOLE VOTING POWER </div>
            <div style="margin-left: 3.6pt;"><br>
            </div>
          </td>
          <td style="width: 34.87%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">-0-</td>
        </tr>
        <tr>
          <td style="width: 18.8%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">6.</div>
          </td>
          <td style="width: 27.72%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div style="margin-left: 3.6pt;">SHARED VOTING POWER </div>
            <div style="margin-left: 3.6pt;"><br>
            </div>
          </td>
          <td style="width: 27.72%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">2,449,183</td>
        </tr>
        <tr>
          <td style="width: 18.8%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">7.</div>
          </td>
          <td style="width: 27.72%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div style="margin-left: 3.6pt;">SOLE DISPOSITIVE POWER </div>
            <br>
          </td>
          <td style="width: 27.72%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">-0-</td>
        </tr>
        <tr>
          <td style="width: 18.8%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">8.</div>
          </td>
          <td style="width: 27.72%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div style="margin-left: 3.6pt;">SHARED DISPOSITIVE POWER </div>
            <div style="margin-left: 3.6pt;"><br>
            </div>
          </td>
          <td style="width: 27.72%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">2,449,183</td>
        </tr>
        <tr>
          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">9.</div>
          </td>
          <td style="width: 47.08%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div style="font-size: 12pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED<br>
              BY EACH REPORTING PERSON <br>
            </div>
          </td>
          <td style="width: 47.08%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div>2,449,183</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">10.</div>
          </td>
          <td style="width: 74.25%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="3">
            <div style="margin-right: 75.6pt; font-size: 12pt;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</div>
          </td>
          <td style="width: 19.92%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">[ &#160; ]</div>
            <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">11.</div>
          </td>
          <td style="width: 47.08%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div style="font-size: 12pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</div>
          </td>
          <td style="width: 47.08%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div>4.98%</div>
            <div> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.83%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">12.</div>
          </td>
          <td style="width: 47.08%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="3">
            <div style="font-size: 12pt;">TYPE OF REPORTING PERSON <br>
            </div>
          </td>
          <td style="width: 47.08%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 12pt;">
            <div>CO</div>
            <div> <br>
            </div>
          </td>
        </tr>

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    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">3</font></div>
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    </div>
    <div>
      <div style="font-size: 12pt;">CUSIP No. 74366E102</div>
      <div style="font-size: 12pt;"> <br>
      </div>
      <div style="font-size: 12pt;"> <br>
      </div>
    </div>
    <div style="text-align: center; font-size: 12pt; font-weight: bold;"><u>AMENDMENT NO. 2 TO SCHEDULE 13G (FINAL AMENDMENT)</u></div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Reference is hereby made to the statement on Schedule 13G filed with the Securities and Exchange Commission by the Reporting Persons with respect to the Common Stock of the Issuer on August 19, 2016 and Amendment No. 1
      thereto filed on February 1, 2021 (as so amended, the &#8220;Schedule 13G&#8221;).&#160; Terms defined in the Schedule 13G are used herein as so defined.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">The following items of the Schedule 13G are amended and restated to read in their entirety as follows:</div>
    <div><br>
    </div>
    <div style="font-size: 12pt; font-weight: bold;">Item 4.&#160; Ownership</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">(a) through (c):</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">The information requested in these paragraphs is incorporated by reference to the cover pages to this Amendment No. 2 to Schedule 13G. Percentage ownership is based on 49,198,411 shares of Common Stock outstanding as of
      October 31, 2022, as reported in the Issuer&#8217;s Report on Form 10-Q for the period ended September 30, 2022 filed with the Securities and Exchange Commission on November 8, 2022.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt; font-weight: bold;">Item 5.&#160; Ownership of Five Percent or Less of the Class</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">If this statement is being filed to report the fact that the Reporting Persons have ceased to be the beneficial owners of more than five percent of the Common Stock, check the following:&#160; [X]</div>
    <div style="font-size: 12pt;"> <br>
    </div>
    <div style="font-size: 12pt;"> <br>
    </div>
    <div style="font-size: 12pt;"> <br>
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    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" class="BRPFPageNumberArea"><font style="font-size: 8pt; font-weight: normal; font-style: normal;" class="BRPFPageNumber">4</font></div>
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div>
      <div style="font-size: 12pt;">CUSIP No. 74366E102</div>
      <div style="font-size: 12pt;"> <br>
      </div>
      <div style="font-size: 12pt;"> <br>
      </div>
    </div>
    <div style="text-align: center; font-size: 12pt;">SIGNATURE</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">After reasonable inquiry and to the best of their knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Dated:&#160; January 11, 2023</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z83239315f60e43e29f0706d309c4736a" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 46.85%; vertical-align: top;">&#160;</td>
          <td style="width: 53.15%; vertical-align: top;" colspan="2">
            <div style="font-size: 12pt;">JOHNSON &amp; JOHNSON</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 46.85%; vertical-align: top;">&#160;</td>
          <td style="width: 9.22%; vertical-align: top;">
            <div style="font-size: 12pt;">By:</div>
          </td>
          <td style="width: 43.94%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">/s/ Marc Larkins</div>
          </td>
        </tr>
        <tr>
          <td style="width: 46.85%; vertical-align: top;">&#160;</td>
          <td style="width: 9.22%; vertical-align: top;">
            <div style="font-size: 12pt;">Name:</div>
          </td>
          <td style="width: 43.94%; vertical-align: top;">
            <div style="font-size: 12pt;">Marc Larkins</div>
          </td>
        </tr>
        <tr>
          <td style="width: 46.85%; vertical-align: top;">&#160;</td>
          <td style="width: 9.22%; vertical-align: top;">
            <div style="font-size: 12pt;">Title:</div>
          </td>
          <td style="width: 43.94%; vertical-align: top;">
            <div style="font-size: 12pt;">Secretary</div>
          </td>
        </tr>
        <tr>
          <td style="width: 46.85%; vertical-align: top;">&#160;</td>
          <td style="width: 9.22%; vertical-align: top;">&#160;</td>
          <td style="width: 43.94%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 46.85%; vertical-align: top;">&#160;</td>
          <td style="width: 9.22%; vertical-align: top;">&#160;</td>
          <td style="width: 43.94%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 46.85%; vertical-align: top;">&#160;</td>
          <td style="width: 53.15%; vertical-align: top;" colspan="2">
            <div style="font-size: 12pt;">JOHNSON &amp; JOHNSON INNOVATION-JJDC, INC.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 46.85%; vertical-align: top;">&#160;</td>
          <td style="width: 9.22%; vertical-align: top;">&#160;</td>
          <td style="width: 43.94%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 46.85%; vertical-align: top;">&#160;</td>
          <td style="width: 9.22%; vertical-align: top;">
            <div style="font-size: 12pt;">By:</div>
          </td>
          <td style="width: 43.94%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">/s/ Jill McManus</div>
          </td>
        </tr>
        <tr>
          <td style="width: 46.85%; vertical-align: top;">&#160;</td>
          <td style="width: 9.22%; vertical-align: top;">
            <div style="font-size: 12pt;">Name:</div>
          </td>
          <td style="width: 43.94%; vertical-align: top;">
            <div style="font-size: 12pt;">Jill McManus</div>
          </td>
        </tr>
        <tr>
          <td style="width: 46.85%; vertical-align: top;">&#160;</td>
          <td style="width: 9.22%; vertical-align: top;">
            <div style="font-size: 12pt;">Title:</div>
          </td>
          <td style="width: 43.94%; vertical-align: top;">
            <div style="font-size: 12pt;">Assistant Treasurer</div>
          </td>
        </tr>

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