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v3.25.3

Acquisitions and divestitures - Narrative (Details) - USD ($) $ / shares in Units, $ in Millions |  |  |  |  |  | 3 Months Ended | 9 Months Ended |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Apr. 02, 2025 | Jul. 11, 2024 | Jun. 20, 2024 | May 31, 2024 | Mar. 07, 2024 | Sep. 28, 2025 | Sep. 28, 2025 | Sep. 29, 2024 | Dec. 29, 2024
Business Combination [Line Items] |  |  |  |  |  |  |  |  |
Payments to acquire businesses |  |  |  |  |  |  | $ 14,459 | $ 15,145 |
Goodwill, related to acquisitions |  |  |  |  |  |  | 2,846 |  |
Contingent consideration |  |  |  |  |  | $ 1,110 | 1,110 |  | $ 1,217
Goodwill (Note 3) |  |  |  |  |  | 48,048 | 48,048 |  | $ 44,200
Ponvory |  |  |  |  |  |  |  |  |
Business Combination [Line Items] |  |  |  |  |  |  |  |  |
Proceeds from sale of business |  |  |  |  |  |  |  | 200 |
Acclarent |  |  |  |  |  |  |  |  |
Business Combination [Line Items] |  |  |  |  |  |  |  |  |
Proceeds from sale of business |  |  |  |  |  |  |  | 300 |
Yellow Jersey Therapeutics |  |  |  |  |  |  |  |  |
Business Combination [Line Items] |  |  |  |  |  |  |  |  |
Consideration transferred |  | $ 1,250 |  |  |  |  |  |  |
In process research and development charge |  | $ 1,250 |  |  |  |  |  |  |
Intra-Cellular Therapies, Inc. |  |  |  |  |  |  |  |  |
Business Combination [Line Items] |  |  |  |  |  |  |  |  |
Share price (in dollars per share) | $ 132.00 |  |  |  |  |  |  |  |
Consideration transferred | $ 14,500 |  |  |  |  |  |  |  |
Acquisition related costs | 300 |  |  |  |  |  |  |  |
Integration-related cost, expense | 100 |  |  |  |  |  |  |  |
Liabilities assumed | 3,000 |  |  |  |  |  |  |  |
Amortizable intangibles asset | 5,200 |  |  |  |  |  |  |  |
Goodwill (Note 3) | 2,900 |  |  |  |  |  |  |  |
Intra-Cellular Therapies, Inc. | In-process research and development |  |  |  |  |  |  |  |  |
Business Combination [Line Items] |  |  |  |  |  |  |  |  |
Business Combination, Recognized Asset Acquired, Identifiable Intangible Asset, Indefinite-Lived | $ 8,300 |  |  |  |  |  |  |  |
Proteologix |  |  |  |  |  |  |  |  |
Business Combination [Line Items] |  |  |  |  |  |  |  |  |
Acquisition related costs |  |  |  |  |  | 0 |  |  |
Payments to acquire businesses |  |  | $ 800 |  |  |  |  |  |
Assets acquired |  |  | 1,200 |  |  |  |  |  |
Goodwill, related to acquisitions |  |  | 300 |  |  |  |  |  |
Liabilities assumed |  |  | 300 |  |  |  |  |  |
Contingent consideration |  |  | 100 |  |  |  |  |  |
Proteologix | In-process research and development |  |  |  |  |  |  |  |  |
Business Combination [Line Items] |  |  |  |  |  |  |  |  |
Business Combination, Recognized Asset Acquired, Identifiable Intangible Asset, Indefinite-Lived |  |  | $ 900 |  |  |  |  |  |
Shockwave Medical, Inc. |  |  |  |  |  |  |  |  |
Business Combination [Line Items] |  |  |  |  |  |  |  |  |
Acquisition related costs |  |  |  |  |  |  | $ 0 | $ 700 |
Payments to acquire businesses |  |  |  | $ 11,500 |  |  |  |  |
Assets acquired |  |  |  | 14,400 |  |  |  |  |
Liabilities assumed |  |  |  | 2,900 |  |  |  |  |
Payments to acquire businesses, gross |  |  |  | 12,600 |  |  |  |  |
Amortizable intangibles asset |  |  |  | 5,300 |  |  |  |  |
Goodwill (Note 3) |  |  |  | 7,600 |  |  |  |  |
Acquired inventory |  |  |  | 500 |  |  |  |  |
Assumed other noncurrent assets |  |  |  | 400 |  |  |  |  |
Shockwave Medical, Inc. | In-process research and development |  |  |  |  |  |  |  |  |
Business Combination [Line Items] |  |  |  |  |  |  |  |  |
Business Combination, Recognized Asset Acquired, Identifiable Intangible Asset, Indefinite-Lived |  |  |  | $ 600 |  |  |  |  |
Ambrx |  |  |  |  |  |  |  |  |
Business Combination [Line Items] |  |  |  |  |  |  |  |  |
Acquisition related costs |  |  |  |  |  | $ 0 |  |  |
Payments to acquire businesses |  |  |  |  | $ 1,800 |  |  |  |
Assets acquired |  |  |  |  | 2,300 |  |  |  |
Goodwill, related to acquisitions |  |  |  |  | 300 |  |  |  |
Liabilities assumed |  |  |  |  | 500 |  |  |  |
Ambrx | In-process research and development |  |  |  |  |  |  |  |  |
Business Combination [Line Items] |  |  |  |  |  |  |  |  |
Business Combination, Recognized Asset Acquired, Identifiable Intangible Asset, Indefinite-Lived |  |  |  |  | $ 1,900 |  |  |  |

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