<SEC-DOCUMENT>0000354950-21-000198.txt : 20210929
<SEC-HEADER>0000354950-21-000198.hdr.sgml : 20210929
<ACCEPTANCE-DATETIME>20210929170515
ACCESSION NUMBER:		0000354950-21-000198
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20210927
FILED AS OF DATE:		20210929
DATE AS OF CHANGE:		20210929

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Campbell Ann Marie
		CENTRAL INDEX KEY:			0001453970

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-08207
		FILM NUMBER:		211292585

	MAIL ADDRESS:	
		STREET 1:		2455 PACES FERRY ROAD
		CITY:			ATLANTA
		STATE:			GA
		ZIP:			30339

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HOME DEPOT, INC.
		CENTRAL INDEX KEY:			0000354950
		STANDARD INDUSTRIAL CLASSIFICATION:	RETAIL-LUMBER & OTHER BUILDING MATERIALS DEALERS [5211]
		IRS NUMBER:				953261426
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0130

	BUSINESS ADDRESS:	
		STREET 1:		2455 PACES FERRY ROAD
		CITY:			ATLANTA
		STATE:			GA
		ZIP:			30339-4024
		BUSINESS PHONE:		770-433-8211

	MAIL ADDRESS:	
		STREET 1:		2455 PACES FERRY ROAD
		CITY:			ATLANTA
		STATE:			GA
		ZIP:			30339-4024

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	HOME DEPOT INC
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>wf-form4_163294950095715.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2021-09-27</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000354950</issuerCik>
        <issuerName>HOME DEPOT, INC.</issuerName>
        <issuerTradingSymbol>HD</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001453970</rptOwnerCik>
            <rptOwnerName>Campbell Ann Marie</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>2455 PACES FERRY RD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>ATLANTA</rptOwnerCity>
            <rptOwnerState>GA</rptOwnerState>
            <rptOwnerZipCode>30339</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>EVP - U.S. Stores &amp; Int'l Ops</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>$.05 Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2021-09-27</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>F</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>787</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>341.41</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>50701.0586</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>$.05 Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>5065</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>by Charitable Remainder Trust</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/Stacy S. Ingram, Attorney-in-Fact</signatureName>
        <signatureDate>2021-09-29</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
