<SEC-DOCUMENT>0000354950-22-000056.txt : 20220303
<SEC-HEADER>0000354950-22-000056.hdr.sgml : 20220303
<ACCEPTANCE-DATETIME>20220303182140
ACCESSION NUMBER:		0000354950-22-000056
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20220301
FILED AS OF DATE:		20220303
DATE AS OF CHANGE:		20220303

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Santilli Paula
		CENTRAL INDEX KEY:			0001773306

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-08207
		FILM NUMBER:		22710948

	MAIL ADDRESS:	
		STREET 1:		PEPSICO, INC., 700 ANDERSON HILL ROAD
		CITY:			PURCHASE
		STATE:			NY
		ZIP:			10577

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HOME DEPOT, INC.
		CENTRAL INDEX KEY:			0000354950
		STANDARD INDUSTRIAL CLASSIFICATION:	RETAIL-LUMBER & OTHER BUILDING MATERIALS DEALERS [5211]
		IRS NUMBER:				953261426
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0130

	BUSINESS ADDRESS:	
		STREET 1:		2455 PACES FERRY ROAD
		CITY:			ATLANTA
		STATE:			GA
		ZIP:			30339-4024
		BUSINESS PHONE:		770-433-8211

	MAIL ADDRESS:	
		STREET 1:		2455 PACES FERRY ROAD
		CITY:			ATLANTA
		STATE:			GA
		ZIP:			30339-4024

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	HOME DEPOT INC
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
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<TYPE>3
<SEQUENCE>1
<FILENAME>wf-form3_164634965422246.xml
<DESCRIPTION>FORM 3
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2022-03-01</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000354950</issuerCik>
        <issuerName>HOME DEPOT, INC.</issuerName>
        <issuerTradingSymbol>HD</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001773306</rptOwnerCik>
            <rptOwnerName>Santilli Paula</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>2455 PACES FERRY RD., SE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>ATLANTA</rptOwnerCity>
            <rptOwnerState>GA</rptOwnerState>
            <rptOwnerZipCode>30339</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Stacy S. Ingram</signatureName>
        <signatureDate>2022-03-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>santillipoa.htm
<DESCRIPTION>PAULA SANTILLI POA
<TEXT>
<!-- Document created using Workiva -->
<html>
<body>
<pre>
Power of Attorney

       The undersigned hereby constitutes and appoints each of Teresa Wynn Roseborough, Jocelyn J. Hunter, Peter J. Muiz and Stacy S. Ingram, the undersigned's true and lawful attorney-in-fact to:

       (1) execute for and on behalf of the undersigned, in the undersigned's capacity as an officer or director of The Home Depot, Inc. (the "Company"), reports on Form 3, Form 4 and Form 5 in accordance with Section 16(a) of the Securities Exchange Act of 1934 and the rules thereunder;
       (2) do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such report on Form 3, Form 4 or Form 5, complete and execute any amendment or amendments thereto, and timely file such form with the Securities and Exchange Commission and any stock exchange or similar authority; and
       (3) take any other action of any type whatsoever in connection with the foregoing which, in the opinion of each such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by each such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as each such attorney-in-fact may approve in each such attorney-in-fact's discretion.
       The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or revocation, hereby ratifying and confirming all that each such attorney-in-fact shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein granted.  The undersigned acknowledges that the foregoing attorneys-in-fact, in serving in such capacity at the request of the undersigned, are not assuming, nor is the Company assuming, any of the undersigned's responsibilities to comply with, or liabilities that may arise under, Section 16 of the Securities Exchange Act of 1934.
       This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file reports on Form 3, Form 4 and Form 5 with respect to the undersigned's holdings of and transactions in securities issued by the Company, unless earlier revoked by the undersigned in a signed writing delivered to the foregoing attorneys-in-fact.
       IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this 30th day of January, 2022.

/s/ Paula Alejandra Santilli
____________________________________
Signature

Paula Alejandra Santilli
___________________________________
Print Name
</pre>
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