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      <link:roleType id="CommonStockandEmployeeEquityPlansDetails" roleURI="http://www.amd.com/role/CommonStockandEmployeeEquityPlansDetails">
        <link:definition>9954500 - Disclosure - Common Stock and Employee Equity Plans (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="IncomeTaxesDetails" roleURI="http://www.amd.com/role/IncomeTaxesDetails">
        <link:definition>9954501 - Disclosure - Income Taxes (Details)</link:definition>
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      <link:roleType id="ContingenciesDetails" roleURI="http://www.amd.com/role/ContingenciesDetails">
        <link:definition>9954502 - Disclosure - Contingencies (Details)</link:definition>
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        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="SubsequentEventsDetails" roleURI="http://www.amd.com/role/SubsequentEventsDetails">
        <link:definition>9954503 - Disclosure - Subsequent Events (Details)</link:definition>
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        <link:usedOn>link:definitionLink</link:usedOn>
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  <xs:element id="amd_AmortizationOfAcquisitionRelatedIntangiblesOpex" abstract="false" name="AmortizationOfAcquisitionRelatedIntangiblesOpex" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="amd_GainOnLicensingAgreement" abstract="false" name="GainOnLicensingAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="amd_InventoryLossAtContractManufacturer" abstract="false" name="InventoryLossAtContractManufacturer" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="amd_FairValueOfCommonStockIssuedAsAcquisitionConsiderationMember" abstract="true" name="FairValueOfCommonStockIssuedAsAcquisitionConsiderationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_PreCombinationUnvestedRestrictedStockUnitsAssumedMember" abstract="true" name="PreCombinationUnvestedRestrictedStockUnitsAssumedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_CommonStockRepurchasesForTaxWithholdingOnEmployeeEquityPlansGross" abstract="false" name="CommonStockRepurchasesForTaxWithholdingOnEmployeeEquityPlansGross" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="amd_FinancialInstrumentsNotRecordedAtFairValueOnRecurringBasisTableTextBlock" abstract="false" name="FinancialInstrumentsNotRecordedAtFairValueOnRecurringBasisTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="amd_NonDeductibleIntangibleAssetsMember" abstract="true" name="NonDeductibleIntangibleAssetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
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  <xs:element id="amd_CustomerProgramAccruals" abstract="false" name="CustomerProgramAccruals" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="amd_PercentageOfRevenueToTotalRevenue" abstract="false" name="PercentageOfRevenueToTotalRevenue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="amd_UsGaap_RevenueRemainingPerformanceObligation12months" abstract="false" name="UsGaap_RevenueRemainingPerformanceObligation12months" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="amd_DataCenterMember" abstract="true" name="DataCenterMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_ClientMember" abstract="true" name="ClientMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_GamingMember" abstract="true" name="GamingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_EmbeddedMember" abstract="true" name="EmbeddedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_ConsiderationTransferredNetOfCashAcquiredMember" abstract="true" name="ConsiderationTransferredNetOfCashAcquiredMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_CommonAndTreasuryStockIssuedMember" abstract="true" name="CommonAndTreasuryStockIssuedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_OperatingLeaseRightOfUseAssetAcquiredMember" abstract="true" name="OperatingLeaseRightOfUseAssetAcquiredMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_TotalAssumedUnvestedRestrictedStockUnitsMember" abstract="true" name="TotalAssumedUnvestedRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_PostCombinationUnvestedRestrictedStockUnitsAssumedMember" abstract="true" name="PostCombinationUnvestedRestrictedStockUnitsAssumedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_PensandoMember" abstract="true" name="PensandoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_XilinxIncMember" abstract="true" name="XilinxIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_SiloAIMember" abstract="true" name="SiloAIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="amd_NumberOfSharesMember" abstract="true" name="NumberOfSharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="amd_CashConsiderationMember" abstract="true" name="CashConsiderationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="amd_ContingentSharesIssuableMember" abstract="true" name="ContingentSharesIssuableMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="amd_ContingentCashConsiderationMember" abstract="true" name="ContingentCashConsiderationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="amd_ZTSystemsMember" abstract="true" name="ZTSystemsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="amd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherLiabilities" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="amd_BusinessCombinationTransactionValue" abstract="false" name="BusinessCombinationTransactionValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="amd_EstimatedLicenseFeesEarnedOverTime" abstract="false" name="EstimatedLicenseFeesEarnedOverTime" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="amd_A295SeniorNotesDue2024Member" abstract="true" name="A295SeniorNotesDue2024Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
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  <xs:element id="amd_A3924SeniorNoteDue2032Member" abstract="true" name="A3924SeniorNoteDue2032Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
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  <xs:element id="amd_SwinglineSubfacilityMember" abstract="true" name="SwinglineSubfacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_LetterOfCreditNOTUSEDMember" abstract="true" name="LetterOfCreditNOTUSEDMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_PrincipalBalanceOfNotesAssumedMember" abstract="true" name="PrincipalBalanceOfNotesAssumedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_AvailableForSaleSecuritiesMaturingInFiveYearsAndLaterMember" abstract="true" name="AvailableForSaleSecuritiesMaturingInFiveYearsAndLaterMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_UsGaap_FairValueMeasurementsRecurringDefCompMember" abstract="true" name="UsGaap_FairValueMeasurementsRecurringDefCompMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="amd_IncrementalCommonSharesAndWarrantAttributableToShareBasedPaymentArrangements" abstract="false" name="IncrementalCommonSharesAndWarrantAttributableToShareBasedPaymentArrangements" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
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  <xs:element id="amd_AcquisitionRelatedStockBasedCompensationCostMember" abstract="true" name="AcquisitionRelatedStockBasedCompensationCostMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="amd_BusinessCombinationReplacementAwardsMember" abstract="true" name="BusinessCombinationReplacementAwardsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
</xs:schema>
