<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2023 Workiva-->
<!--r:ca2a67d9-75cc-4844-ae6b-42d9b97817b9,g:e222fb04-75fd-440d-846d-7e9ee4733a2e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.applovin.com/role/CoverPage" xlink:type="simple" xlink:href="app-20230331.xsd#CoverPage"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/CoverPage" xlink:type="extended" id="i686fa4fd796a405ebca27d19fd73c152_CoverPage">
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_de2123c3-34a8-4b76-a5d8-48ace3de91ad" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_DocumentType_de2123c3-34a8-4b76-a5d8-48ace3de91ad" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_3baed150-c369-4192-855e-3508b4cb9bec" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentQuarterlyReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_DocumentQuarterlyReport_3baed150-c369-4192-855e-3508b4cb9bec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_25d76bbd-9150-40fd-adde-3c5263822f69" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_DocumentPeriodEndDate_25d76bbd-9150-40fd-adde-3c5263822f69" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_4956d310-171b-47f6-b065-80e719b96c9a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentTransitionReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_DocumentTransitionReport_4956d310-171b-47f6-b065-80e719b96c9a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_b2ac1d10-e920-4e56-9b84-6d4f19978879" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntityFileNumber_b2ac1d10-e920-4e56-9b84-6d4f19978879" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_a7a4bbbb-4dbb-4c3a-a27f-ebc1b7cf9dd1" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntityRegistrantName_a7a4bbbb-4dbb-4c3a-a27f-ebc1b7cf9dd1" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_3489653e-b094-4300-aca1-4b8f19e191cf" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntityIncorporationStateCountryCode_3489653e-b094-4300-aca1-4b8f19e191cf" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_7b45ecdf-ad56-4b8f-afcd-4b55fb10c454" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntityTaxIdentificationNumber_7b45ecdf-ad56-4b8f-afcd-4b55fb10c454" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_be14d589-ca9a-4581-a452-a263789c0723" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntityAddressAddressLine1_be14d589-ca9a-4581-a452-a263789c0723" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_4e7c9dad-5fe2-49a9-ab1e-6a663acfffe3" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntityAddressCityOrTown_4e7c9dad-5fe2-49a9-ab1e-6a663acfffe3" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_381f9eb2-43c8-42dc-9e68-116cc1fea8de" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntityAddressStateOrProvince_381f9eb2-43c8-42dc-9e68-116cc1fea8de" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_949d9236-59aa-4172-80c9-9f5c04c1c65a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntityAddressPostalZipCode_949d9236-59aa-4172-80c9-9f5c04c1c65a" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_5fbe1571-62b6-4b29-9507-485f09f25c72" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_CityAreaCode_5fbe1571-62b6-4b29-9507-485f09f25c72" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_802ae214-41bf-4598-aa31-52d396cf3e20" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_LocalPhoneNumber_802ae214-41bf-4598-aa31-52d396cf3e20" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_a2482be3-4e3b-4718-9f46-2be4c67bf3a3" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_Security12bTitle_a2482be3-4e3b-4718-9f46-2be4c67bf3a3" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_9a90ab3b-d23d-4d31-a9f9-f16d11c63f4f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_TradingSymbol_9a90ab3b-d23d-4d31-a9f9-f16d11c63f4f" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_3ca1f176-69c7-43cd-acc3-aaf727250d7f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_SecurityExchangeName_3ca1f176-69c7-43cd-acc3-aaf727250d7f" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_8067dea7-4039-4b61-9660-704f9b54f61b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCurrentReportingStatus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntityCurrentReportingStatus_8067dea7-4039-4b61-9660-704f9b54f61b" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_75cfb2b5-b9f0-4e2c-8e9c-0a5541bce713" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntityInteractiveDataCurrent_75cfb2b5-b9f0-4e2c-8e9c-0a5541bce713" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_d79a086a-6ac9-411c-845b-9a1714d70cc9" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFilerCategory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntityFilerCategory_d79a086a-6ac9-411c-845b-9a1714d70cc9" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_2de16eff-edf4-44bd-8349-ba06803da0b4" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntitySmallBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntitySmallBusiness_2de16eff-edf4-44bd-8349-ba06803da0b4" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_f6f2cff1-234c-4e16-a6df-a15447b93f58" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntityEmergingGrowthCompany_f6f2cff1-234c-4e16-a6df-a15447b93f58" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_950da267-47db-4887-bc8a-b8d135d51f51" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityShellCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntityShellCompany_950da267-47db-4887-bc8a-b8d135d51f51" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_f422901d-5ddd-4067-9cce-47e563fa5c66" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_f422901d-5ddd-4067-9cce-47e563fa5c66" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_e945f035-1ef2-4ab4-ae52-84ff4e26c39f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_AmendmentFlag_e945f035-1ef2-4ab4-ae52-84ff4e26c39f" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_989e3713-a823-42c8-adf6-97b84f9423c5" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_DocumentFiscalPeriodFocus_989e3713-a823-42c8-adf6-97b84f9423c5" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_061e06e8-a1e3-430b-9c33-6761624afea8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalYearFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_DocumentFiscalYearFocus_061e06e8-a1e3-430b-9c33-6761624afea8" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_00e24807-5cad-4870-aa8a-7cd7342da427" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_CurrentFiscalYearEndDate_00e24807-5cad-4870-aa8a-7cd7342da427" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_b92bb1c7-1a92-4402-af21-adc56c739eda" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_EntityCentralIndexKey_b92bb1c7-1a92-4402-af21-adc56c739eda" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_9d0a3d1b-dc82-4c42-b70d-1a798ebeece1" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentInformationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_DocumentInformationLineItems_54be29b3-e72e-4420-b399-4f71beab2653" xlink:to="loc_dei_DocumentInformationTable_9d0a3d1b-dc82-4c42-b70d-1a798ebeece1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_9717eda8-6dee-45d2-a6d1-168cc96c7c20" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_DocumentInformationTable_9d0a3d1b-dc82-4c42-b70d-1a798ebeece1" xlink:to="loc_us-gaap_StatementClassOfStockAxis_9717eda8-6dee-45d2-a6d1-168cc96c7c20" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_9717eda8-6dee-45d2-a6d1-168cc96c7c20_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_9717eda8-6dee-45d2-a6d1-168cc96c7c20" xlink:to="loc_us-gaap_ClassOfStockDomain_9717eda8-6dee-45d2-a6d1-168cc96c7c20_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_83ee694b-13d7-4628-b994-af57a6b7fd39" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_9717eda8-6dee-45d2-a6d1-168cc96c7c20" xlink:to="loc_us-gaap_ClassOfStockDomain_83ee694b-13d7-4628-b994-af57a6b7fd39" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_3add6e94-b977-47bd-ac57-e9ea0f5dd9bf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_83ee694b-13d7-4628-b994-af57a6b7fd39" xlink:to="loc_us-gaap_CommonClassAMember_3add6e94-b977-47bd-ac57-e9ea0f5dd9bf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_bf4561c2-8f78-4c6f-be19-0ae50d5ee1a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_83ee694b-13d7-4628-b994-af57a6b7fd39" xlink:to="loc_us-gaap_CommonClassBMember_bf4561c2-8f78-4c6f-be19-0ae50d5ee1a0" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="app-20230331.xsd#CondensedConsolidatedBalanceSheetsParenthetical"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="extended" id="i3df1b25114c04f59a0c9f6300f542fc0_CondensedConsolidatedBalanceSheetsParenthetical">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_3d4c4e6b-be86-4cc9-aba6-b35fcc4b700a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_212d2c34-a41f-4ef9-99d7-814c8d1dee31" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3d4c4e6b-be86-4cc9-aba6-b35fcc4b700a" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_212d2c34-a41f-4ef9-99d7-814c8d1dee31" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_d6969ba0-bf49-4790-bf7b-f948aedb9dcf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3d4c4e6b-be86-4cc9-aba6-b35fcc4b700a" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_d6969ba0-bf49-4790-bf7b-f948aedb9dcf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesIssued_41cc2f01-754a-4368-9bcd-8a69b7a52e4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3d4c4e6b-be86-4cc9-aba6-b35fcc4b700a" xlink:to="loc_us-gaap_PreferredStockSharesIssued_41cc2f01-754a-4368-9bcd-8a69b7a52e4d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_6cea95c0-6a94-40e8-8689-c44c39eb0a71" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3d4c4e6b-be86-4cc9-aba6-b35fcc4b700a" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_6cea95c0-6a94-40e8-8689-c44c39eb0a71" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_7d9e91b8-7a5e-4c8d-859f-323027403782" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3d4c4e6b-be86-4cc9-aba6-b35fcc4b700a" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_7d9e91b8-7a5e-4c8d-859f-323027403782" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_bac2afeb-d65a-4048-a2d1-4c6e006a9b82" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3d4c4e6b-be86-4cc9-aba6-b35fcc4b700a" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_bac2afeb-d65a-4048-a2d1-4c6e006a9b82" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_32b864c4-7d29-458a-b07d-15a23a323a8d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3d4c4e6b-be86-4cc9-aba6-b35fcc4b700a" xlink:to="loc_us-gaap_CommonStockSharesIssued_32b864c4-7d29-458a-b07d-15a23a323a8d" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_7d342674-0d79-4d68-bfb6-dc6749490359" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3d4c4e6b-be86-4cc9-aba6-b35fcc4b700a" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_7d342674-0d79-4d68-bfb6-dc6749490359" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_151f32bf-4f3e-416c-ba55-f03aaa460af2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_3d4c4e6b-be86-4cc9-aba6-b35fcc4b700a" xlink:to="loc_us-gaap_StatementTable_151f32bf-4f3e-416c-ba55-f03aaa460af2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_68526a31-4f80-4d8c-a63c-44d0e7fc276f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_151f32bf-4f3e-416c-ba55-f03aaa460af2" xlink:to="loc_us-gaap_StatementClassOfStockAxis_68526a31-4f80-4d8c-a63c-44d0e7fc276f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_68526a31-4f80-4d8c-a63c-44d0e7fc276f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_68526a31-4f80-4d8c-a63c-44d0e7fc276f" xlink:to="loc_us-gaap_ClassOfStockDomain_68526a31-4f80-4d8c-a63c-44d0e7fc276f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_9c6f01e2-9e77-4bfd-b80d-dfe186030f5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_68526a31-4f80-4d8c-a63c-44d0e7fc276f" xlink:to="loc_us-gaap_ClassOfStockDomain_9c6f01e2-9e77-4bfd-b80d-dfe186030f5c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_ed252743-3afa-4f56-8c7c-fba667915340" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_9c6f01e2-9e77-4bfd-b80d-dfe186030f5c" xlink:to="loc_us-gaap_CommonClassAMember_ed252743-3afa-4f56-8c7c-fba667915340" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_6e0d8d4b-70ab-47da-8528-7d62d5020306" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_9c6f01e2-9e77-4bfd-b80d-dfe186030f5c" xlink:to="loc_us-gaap_CommonClassBMember_6e0d8d4b-70ab-47da-8528-7d62d5020306" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/CondensedConsolidatedStatementsofRedeemableNoncontrollingInterestandStockholdersEquity" xlink:type="simple" xlink:href="app-20230331.xsd#CondensedConsolidatedStatementsofRedeemableNoncontrollingInterestandStockholdersEquity"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/CondensedConsolidatedStatementsofRedeemableNoncontrollingInterestandStockholdersEquity" xlink:type="extended" id="idad7bc1afdec47dfb03de7e02c937da9_CondensedConsolidatedStatementsofRedeemableNoncontrollingInterestandStockholdersEquity">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_483a8969-2b6b-4595-98aa-1f4d2a992666" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_5a0ef506-5c52-471d-b978-f4ecb7a3a727" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInTemporaryEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_483a8969-2b6b-4595-98aa-1f4d2a992666" xlink:to="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_5a0ef506-5c52-471d-b978-f4ecb7a3a727" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount_cf0dd9a5-284a-4a6f-8837-ce9f5a5959d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_5a0ef506-5c52-471d-b978-f4ecb7a3a727" xlink:to="loc_us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount_cf0dd9a5-284a-4a6f-8837-ce9f5a5959d8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToRedeemableNoncontrollingInterest_5c07e55e-cb2c-497b-986e-289f158f9096" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAttributableToRedeemableNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_5a0ef506-5c52-471d-b978-f4ecb7a3a727" xlink:to="loc_us-gaap_NetIncomeLossAttributableToRedeemableNoncontrollingInterest_5c07e55e-cb2c-497b-986e-289f158f9096" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount_909a4a4b-407b-493b-a001-433acffc11ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_c50278b8-6a1e-448d-b9f5-33ebc5a83a89" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_483a8969-2b6b-4595-98aa-1f4d2a992666" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_c50278b8-6a1e-448d-b9f5-33ebc5a83a89" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_73eb94b2-4f6d-4131-8040-90f155a2994f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_c50278b8-6a1e-448d-b9f5-33ebc5a83a89" xlink:to="loc_us-gaap_SharesOutstanding_73eb94b2-4f6d-4131-8040-90f155a2994f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_55a67ccc-f9fb-46ba-bd5d-e91d99ed04be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_c50278b8-6a1e-448d-b9f5-33ebc5a83a89" xlink:to="loc_us-gaap_StockholdersEquity_55a67ccc-f9fb-46ba-bd5d-e91d99ed04be" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_0f4bc205-1482-4411-9f2f-e6753e82bdf4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_c50278b8-6a1e-448d-b9f5-33ebc5a83a89" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_0f4bc205-1482-4411-9f2f-e6753e82bdf4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_430d3bfe-85d5-4f77-a1d1-af9bbb9ea5da" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_c50278b8-6a1e-448d-b9f5-33ebc5a83a89" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_430d3bfe-85d5-4f77-a1d1-af9bbb9ea5da" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_37560ae6-65dd-4a17-940d-121388a09580" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_c50278b8-6a1e-448d-b9f5-33ebc5a83a89" xlink:to="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_37560ae6-65dd-4a17-940d-121388a09580" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_72186e59-496f-4bfd-b85d-68e4637b70b1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_c50278b8-6a1e-448d-b9f5-33ebc5a83a89" xlink:to="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_72186e59-496f-4bfd-b85d-68e4637b70b1" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_e54f1de8-fa6f-47cd-93b7-722d1ed05f8a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_c50278b8-6a1e-448d-b9f5-33ebc5a83a89" xlink:to="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_e54f1de8-fa6f-47cd-93b7-722d1ed05f8a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_062b638a-0d35-49e0-b17b-414ff7f71d4e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_c50278b8-6a1e-448d-b9f5-33ebc5a83a89" xlink:to="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_062b638a-0d35-49e0-b17b-414ff7f71d4e" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_80033a81-f378-4553-a8df-cd4f53e1263f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_c50278b8-6a1e-448d-b9f5-33ebc5a83a89" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_80033a81-f378-4553-a8df-cd4f53e1263f" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_cfbcf8e9-e7a5-4c24-902c-5e34649dd434" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_c50278b8-6a1e-448d-b9f5-33ebc5a83a89" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_cfbcf8e9-e7a5-4c24-902c-5e34649dd434" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_314b2823-ba4d-4261-84fc-8600a73fecf5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_c50278b8-6a1e-448d-b9f5-33ebc5a83a89" xlink:to="loc_us-gaap_NetIncomeLoss_314b2823-ba4d-4261-84fc-8600a73fecf5" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_7066a855-e233-491c-a0af-76c7d1bfeb3b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_f0ab6eb0-cfc5-4537-82f7-6663a0813222" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_5d85ba41-b49e-4c2b-b895-b76c555b31a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_483a8969-2b6b-4595-98aa-1f4d2a992666" xlink:to="loc_us-gaap_StatementTable_5d85ba41-b49e-4c2b-b895-b76c555b31a2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_5d3a3255-8088-45a1-9a59-320f399aa55b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_5d85ba41-b49e-4c2b-b895-b76c555b31a2" xlink:to="loc_us-gaap_StatementClassOfStockAxis_5d3a3255-8088-45a1-9a59-320f399aa55b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_5d3a3255-8088-45a1-9a59-320f399aa55b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_5d3a3255-8088-45a1-9a59-320f399aa55b" xlink:to="loc_us-gaap_ClassOfStockDomain_5d3a3255-8088-45a1-9a59-320f399aa55b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_c5294204-f997-4fe7-9146-95b2fe8fe1cb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_5d3a3255-8088-45a1-9a59-320f399aa55b" xlink:to="loc_us-gaap_ClassOfStockDomain_c5294204-f997-4fe7-9146-95b2fe8fe1cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_RedeemableNonControllingEquityMember_2802b233-ea50-4a61-9ff1-c2ed6829edd4" xlink:href="app-20230331.xsd#app_RedeemableNonControllingEquityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c5294204-f997-4fe7-9146-95b2fe8fe1cb" xlink:to="loc_app_RedeemableNonControllingEquityMember_2802b233-ea50-4a61-9ff1-c2ed6829edd4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_366b816d-afb7-4ee9-981a-54977364f83a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_5d85ba41-b49e-4c2b-b895-b76c555b31a2" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_366b816d-afb7-4ee9-981a-54977364f83a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_366b816d-afb7-4ee9-981a-54977364f83a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_366b816d-afb7-4ee9-981a-54977364f83a" xlink:to="loc_us-gaap_EquityComponentDomain_366b816d-afb7-4ee9-981a-54977364f83a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_633be545-efff-4cc6-9144-dceada663069" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_366b816d-afb7-4ee9-981a-54977364f83a" xlink:to="loc_us-gaap_EquityComponentDomain_633be545-efff-4cc6-9144-dceada663069" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_95969da5-7616-4c65-bd82-91e5b7c1041e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_633be545-efff-4cc6-9144-dceada663069" xlink:to="loc_us-gaap_CommonStockMember_95969da5-7616-4c65-bd82-91e5b7c1041e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_1959e917-9f4f-4245-b1ce-d3429b8ec5b8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_633be545-efff-4cc6-9144-dceada663069" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_1959e917-9f4f-4245-b1ce-d3429b8ec5b8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_54aea3b6-07d1-451a-9d91-52d391c6a56b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_633be545-efff-4cc6-9144-dceada663069" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_54aea3b6-07d1-451a-9d91-52d391c6a56b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_ba6fd373-010c-45fd-b82a-fdb525a5bc70" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_633be545-efff-4cc6-9144-dceada663069" xlink:to="loc_us-gaap_RetainedEarningsMember_ba6fd373-010c-45fd-b82a-fdb525a5bc70" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/RevenueNarrativeDetails" xlink:type="simple" xlink:href="app-20230331.xsd#RevenueNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/RevenueNarrativeDetails" xlink:type="extended" id="i94d089e2ab3f4398862c636105ae10e5_RevenueNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_47816bb5-3b28-4963-aa9c-4625f5fb74fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_RevenueFromContractWithCustomerEstimatedAverageUserLife_ed49017c-c936-4732-bd94-b298fd3c34fc" xlink:href="app-20230331.xsd#app_RevenueFromContractWithCustomerEstimatedAverageUserLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_47816bb5-3b28-4963-aa9c-4625f5fb74fc" xlink:to="loc_app_RevenueFromContractWithCustomerEstimatedAverageUserLife_ed49017c-c936-4732-bd94-b298fd3c34fc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_93d03979-f283-4938-a759-bfaaf111865b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_47816bb5-3b28-4963-aa9c-4625f5fb74fc" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_93d03979-f283-4938-a759-bfaaf111865b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_ConsiderationIncurredForExistingAndPotentialCustomerIncentiveBonuses_ba836ab2-4e2a-4f39-8131-5926047eee92" xlink:href="app-20230331.xsd#app_ConsiderationIncurredForExistingAndPotentialCustomerIncentiveBonuses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_47816bb5-3b28-4963-aa9c-4625f5fb74fc" xlink:to="loc_app_ConsiderationIncurredForExistingAndPotentialCustomerIncentiveBonuses_ba836ab2-4e2a-4f39-8131-5926047eee92" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_3b4542d0-a316-430c-8d71-7dad795dfd04" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_47816bb5-3b28-4963-aa9c-4625f5fb74fc" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_3b4542d0-a316-430c-8d71-7dad795dfd04" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_7ddfd527-6c5b-44fa-a3b2-2a6d6587b8f6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_3b4542d0-a316-430c-8d71-7dad795dfd04" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_7ddfd527-6c5b-44fa-a3b2-2a6d6587b8f6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7ddfd527-6c5b-44fa-a3b2-2a6d6587b8f6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_7ddfd527-6c5b-44fa-a3b2-2a6d6587b8f6" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7ddfd527-6c5b-44fa-a3b2-2a6d6587b8f6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_030af3d8-8112-48e3-a702-d8034911add0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_7ddfd527-6c5b-44fa-a3b2-2a6d6587b8f6" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_030af3d8-8112-48e3-a702-d8034911add0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_MoPubMember_50eaae6e-114e-4fb3-9d44-3a17aadbc87c" xlink:href="app-20230331.xsd#app_MoPubMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_030af3d8-8112-48e3-a702-d8034911add0" xlink:to="loc_app_MoPubMember_50eaae6e-114e-4fb3-9d44-3a17aadbc87c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_b8c03b66-3750-4ccc-89ba-e118a7277083" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_3b4542d0-a316-430c-8d71-7dad795dfd04" xlink:to="loc_srt_ConsolidationItemsAxis_b8c03b66-3750-4ccc-89ba-e118a7277083" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_b8c03b66-3750-4ccc-89ba-e118a7277083_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_b8c03b66-3750-4ccc-89ba-e118a7277083" xlink:to="loc_srt_ConsolidationItemsDomain_b8c03b66-3750-4ccc-89ba-e118a7277083_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_a29332ba-ec5a-40fb-b0b1-6cda50713476" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_b8c03b66-3750-4ccc-89ba-e118a7277083" xlink:to="loc_srt_ConsolidationItemsDomain_a29332ba-ec5a-40fb-b0b1-6cda50713476" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaterialReconcilingItemsMember_a706673e-ab49-4ae9-a096-cd6b4ccb822c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MaterialReconcilingItemsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_a29332ba-ec5a-40fb-b0b1-6cda50713476" xlink:to="loc_us-gaap_MaterialReconcilingItemsMember_a706673e-ab49-4ae9-a096-cd6b4ccb822c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_9e641bcb-0aa1-4e4b-8b4f-17ba0e154455" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_3b4542d0-a316-430c-8d71-7dad795dfd04" xlink:to="loc_srt_ProductOrServiceAxis_9e641bcb-0aa1-4e4b-8b4f-17ba0e154455" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_9e641bcb-0aa1-4e4b-8b4f-17ba0e154455_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_9e641bcb-0aa1-4e4b-8b4f-17ba0e154455" xlink:to="loc_srt_ProductsAndServicesDomain_9e641bcb-0aa1-4e4b-8b4f-17ba0e154455_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_5936c4b4-9a9c-4d56-b84c-992b3c349756" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_9e641bcb-0aa1-4e4b-8b4f-17ba0e154455" xlink:to="loc_srt_ProductsAndServicesDomain_5936c4b4-9a9c-4d56-b84c-992b3c349756" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_DurableVirtualGoodsMember_dec773d5-9ff3-4e0a-80e4-c89ed28d2079" xlink:href="app-20230331.xsd#app_DurableVirtualGoodsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_5936c4b4-9a9c-4d56-b84c-992b3c349756" xlink:to="loc_app_DurableVirtualGoodsMember_dec773d5-9ff3-4e0a-80e4-c89ed28d2079" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_1a2108dd-fc4e-4e43-9ec5-c428a67d49b4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_3b4542d0-a316-430c-8d71-7dad795dfd04" xlink:to="loc_srt_RangeAxis_1a2108dd-fc4e-4e43-9ec5-c428a67d49b4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_1a2108dd-fc4e-4e43-9ec5-c428a67d49b4_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_1a2108dd-fc4e-4e43-9ec5-c428a67d49b4" xlink:to="loc_srt_RangeMember_1a2108dd-fc4e-4e43-9ec5-c428a67d49b4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_fc3cbf1f-2a0f-4d26-bf08-e7ad94e68cba" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_1a2108dd-fc4e-4e43-9ec5-c428a67d49b4" xlink:to="loc_srt_RangeMember_fc3cbf1f-2a0f-4d26-bf08-e7ad94e68cba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_7ab7f8dd-f094-4e8e-8862-5486b938dcbb" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_fc3cbf1f-2a0f-4d26-bf08-e7ad94e68cba" xlink:to="loc_srt_MinimumMember_7ab7f8dd-f094-4e8e-8862-5486b938dcbb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_4d6f1206-f535-428a-ad3f-ea619fcd98f9" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_fc3cbf1f-2a0f-4d26-bf08-e7ad94e68cba" xlink:to="loc_srt_MaximumMember_4d6f1206-f535-428a-ad3f-ea619fcd98f9" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/RevenueSummaryofRevenueDisaggregatedbyTypeDetails" xlink:type="simple" xlink:href="app-20230331.xsd#RevenueSummaryofRevenueDisaggregatedbyTypeDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/RevenueSummaryofRevenueDisaggregatedbyTypeDetails" xlink:type="extended" id="i00ec1d0f38f846f0a48ef5cffbd93ff6_RevenueSummaryofRevenueDisaggregatedbyTypeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_e9aa1263-59bc-4dc4-b003-06d047e281af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_a5277fab-029e-4156-963c-7fcb6103b4f8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_e9aa1263-59bc-4dc4-b003-06d047e281af" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_a5277fab-029e-4156-963c-7fcb6103b4f8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_019e0574-938f-4f9f-8280-fd9ad9cb186e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_e9aa1263-59bc-4dc4-b003-06d047e281af" xlink:to="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_019e0574-938f-4f9f-8280-fd9ad9cb186e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_a26523c5-064d-42e1-ab0f-30c07707d323" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_019e0574-938f-4f9f-8280-fd9ad9cb186e" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_a26523c5-064d-42e1-ab0f-30c07707d323" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_a26523c5-064d-42e1-ab0f-30c07707d323_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_a26523c5-064d-42e1-ab0f-30c07707d323" xlink:to="loc_us-gaap_SegmentDomain_a26523c5-064d-42e1-ab0f-30c07707d323_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_fc2ba5b8-eeb7-4eb6-bba7-8684dca74b3f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_a26523c5-064d-42e1-ab0f-30c07707d323" xlink:to="loc_us-gaap_SegmentDomain_fc2ba5b8-eeb7-4eb6-bba7-8684dca74b3f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_SoftwarePlatformMember_724867a5-d230-4ef6-b110-bc6e28b4d31a" xlink:href="app-20230331.xsd#app_SoftwarePlatformMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_fc2ba5b8-eeb7-4eb6-bba7-8684dca74b3f" xlink:to="loc_app_SoftwarePlatformMember_724867a5-d230-4ef6-b110-bc6e28b4d31a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_AppsMember_a7036951-8eeb-480d-ac24-e841770582f6" xlink:href="app-20230331.xsd#app_AppsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_fc2ba5b8-eeb7-4eb6-bba7-8684dca74b3f" xlink:to="loc_app_AppsMember_a7036951-8eeb-480d-ac24-e841770582f6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_AppsRevenueConsumerRevenueMember_ecdf74de-b79e-4320-ba1a-65d45d682dec" xlink:href="app-20230331.xsd#app_AppsRevenueConsumerRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_app_AppsMember_a7036951-8eeb-480d-ac24-e841770582f6" xlink:to="loc_app_AppsRevenueConsumerRevenueMember_ecdf74de-b79e-4320-ba1a-65d45d682dec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_AppsRevenueBusinessRevenueMember_c28c9336-a943-4470-a00e-632d606f798f" xlink:href="app-20230331.xsd#app_AppsRevenueBusinessRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_app_AppsMember_a7036951-8eeb-480d-ac24-e841770582f6" xlink:to="loc_app_AppsRevenueBusinessRevenueMember_c28c9336-a943-4470-a00e-632d606f798f" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/RevenueSummaryofRevenueDisaggregatedbyGeographyDetails" xlink:type="simple" xlink:href="app-20230331.xsd#RevenueSummaryofRevenueDisaggregatedbyGeographyDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/RevenueSummaryofRevenueDisaggregatedbyGeographyDetails" xlink:type="extended" id="i8ac6a5cf7b83464888512d98365c3541_RevenueSummaryofRevenueDisaggregatedbyGeographyDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_983aa1da-51da-47ab-980e-d796f8bec3d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_e70c094b-c343-47a5-8e9b-01e9f3fe21ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_983aa1da-51da-47ab-980e-d796f8bec3d6" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_e70c094b-c343-47a5-8e9b-01e9f3fe21ae" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_4fe8b365-5d44-4ec1-a8a9-6cbba7e97389" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_983aa1da-51da-47ab-980e-d796f8bec3d6" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_4fe8b365-5d44-4ec1-a8a9-6cbba7e97389" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_9f7cd3d1-1c80-417d-ab9e-dc992518e9e3" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_4fe8b365-5d44-4ec1-a8a9-6cbba7e97389" xlink:to="loc_srt_StatementGeographicalAxis_9f7cd3d1-1c80-417d-ab9e-dc992518e9e3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_9f7cd3d1-1c80-417d-ab9e-dc992518e9e3_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_9f7cd3d1-1c80-417d-ab9e-dc992518e9e3" xlink:to="loc_srt_SegmentGeographicalDomain_9f7cd3d1-1c80-417d-ab9e-dc992518e9e3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_d60df3c5-81b6-4b36-a87f-0c12fc1d8c4d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_9f7cd3d1-1c80-417d-ab9e-dc992518e9e3" xlink:to="loc_srt_SegmentGeographicalDomain_d60df3c5-81b6-4b36-a87f-0c12fc1d8c4d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_d04a0192-f2aa-41d5-8a51-ab3fb3b0a631" xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_d60df3c5-81b6-4b36-a87f-0c12fc1d8c4d" xlink:to="loc_country_US_d04a0192-f2aa-41d5-8a51-ab3fb3b0a631" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_RestOfTheWorldMember_bcc0785a-c5e1-4bd4-b246-6d2c0204ea99" xlink:href="app-20230331.xsd#app_RestOfTheWorldMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_d60df3c5-81b6-4b36-a87f-0c12fc1d8c4d" xlink:to="loc_app_RestOfTheWorldMember_bcc0785a-c5e1-4bd4-b246-6d2c0204ea99" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/FairValueMeasurementsSummaryofFinancialInstrumentsMeasuredatFairValueDetails" xlink:type="simple" xlink:href="app-20230331.xsd#FairValueMeasurementsSummaryofFinancialInstrumentsMeasuredatFairValueDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/FairValueMeasurementsSummaryofFinancialInstrumentsMeasuredatFairValueDetails" xlink:type="extended" id="if357c20460fd4dd991429e549ace1ec5_FairValueMeasurementsSummaryofFinancialInstrumentsMeasuredatFairValueDetails">
    <link:loc xlink:type="locator" xlink:label="loc_app_FairValueByFairValueHierarchyLevelLineItems_1c22ca97-b936-4538-bb48-5abb4a9fb131" xlink:href="app-20230331.xsd#app_FairValueByFairValueHierarchyLevelLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_2178fe3e-7f84-4e09-86d1-1d9eebc2bef9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_app_FairValueByFairValueHierarchyLevelLineItems_1c22ca97-b936-4538-bb48-5abb4a9fb131" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_2178fe3e-7f84-4e09-86d1-1d9eebc2bef9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_26ede884-10e7-4455-8a72-9f1c367aba59" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_app_FairValueByFairValueHierarchyLevelLineItems_1c22ca97-b936-4538-bb48-5abb4a9fb131" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_26ede884-10e7-4455-8a72-9f1c367aba59" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsMoneyMarketDeposits_a74420af-5df7-4dfd-a980-7561093ea17e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepositsMoneyMarketDeposits"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_app_FairValueByFairValueHierarchyLevelLineItems_1c22ca97-b936-4538-bb48-5abb4a9fb131" xlink:to="loc_us-gaap_DepositsMoneyMarketDeposits_a74420af-5df7-4dfd-a980-7561093ea17e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_FairValueAssetsMeasuredOnRecurringBasisTable_ff924dd4-c916-4d67-92a8-6614d143e548" xlink:href="app-20230331.xsd#app_FairValueAssetsMeasuredOnRecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_app_FairValueByFairValueHierarchyLevelLineItems_1c22ca97-b936-4538-bb48-5abb4a9fb131" xlink:to="loc_app_FairValueAssetsMeasuredOnRecurringBasisTable_ff924dd4-c916-4d67-92a8-6614d143e548" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_e9111cca-d2aa-4d28-a72e-084d85e026c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_app_FairValueAssetsMeasuredOnRecurringBasisTable_ff924dd4-c916-4d67-92a8-6614d143e548" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_e9111cca-d2aa-4d28-a72e-084d85e026c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_e9111cca-d2aa-4d28-a72e-084d85e026c6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_e9111cca-d2aa-4d28-a72e-084d85e026c6" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_e9111cca-d2aa-4d28-a72e-084d85e026c6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_bee07668-6cd6-4549-8a8d-ea4dcf8ad5ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_e9111cca-d2aa-4d28-a72e-084d85e026c6" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_bee07668-6cd6-4549-8a8d-ea4dcf8ad5ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_0b709d22-4b29-4f13-bf93-60d2dfc88c40" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_bee07668-6cd6-4549-8a8d-ea4dcf8ad5ee" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_0b709d22-4b29-4f13-bf93-60d2dfc88c40" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_bd36f5b0-701d-4f87-a9e5-431ba51ec6f5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_bee07668-6cd6-4549-8a8d-ea4dcf8ad5ee" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_bd36f5b0-701d-4f87-a9e5-431ba51ec6f5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_fbd00a39-f151-4515-bd6e-5894b537be93" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_bee07668-6cd6-4549-8a8d-ea4dcf8ad5ee" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_fbd00a39-f151-4515-bd6e-5894b537be93" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_fe3ed5b0-ec7d-4263-a9a2-447a48e2a49d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_app_FairValueAssetsMeasuredOnRecurringBasisTable_ff924dd4-c916-4d67-92a8-6614d143e548" xlink:to="loc_us-gaap_FinancialInstrumentAxis_fe3ed5b0-ec7d-4263-a9a2-447a48e2a49d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_fe3ed5b0-ec7d-4263-a9a2-447a48e2a49d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_fe3ed5b0-ec7d-4263-a9a2-447a48e2a49d" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_fe3ed5b0-ec7d-4263-a9a2-447a48e2a49d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1caf643c-a56e-4326-8634-4b80a2df3a97" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_fe3ed5b0-ec7d-4263-a9a2-447a48e2a49d" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1caf643c-a56e-4326-8634-4b80a2df3a97" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_35d89211-bbbc-4ef7-85c6-98b8fe6d85c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1caf643c-a56e-4326-8634-4b80a2df3a97" xlink:to="loc_us-gaap_MoneyMarketFundsMember_35d89211-bbbc-4ef7-85c6-98b8fe6d85c8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_be562048-3f05-43c2-ae97-6086d961a28f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1caf643c-a56e-4326-8634-4b80a2df3a97" xlink:to="loc_us-gaap_InterestRateSwapMember_be562048-3f05-43c2-ae97-6086d961a28f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_1355f13e-18e1-4b68-a703-7959683486e5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_app_FairValueAssetsMeasuredOnRecurringBasisTable_ff924dd4-c916-4d67-92a8-6614d143e548" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_1355f13e-18e1-4b68-a703-7959683486e5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_1355f13e-18e1-4b68-a703-7959683486e5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_1355f13e-18e1-4b68-a703-7959683486e5" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_1355f13e-18e1-4b68-a703-7959683486e5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_a78beb7c-b114-40be-b842-dcdf02b0d34c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_1355f13e-18e1-4b68-a703-7959683486e5" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_a78beb7c-b114-40be-b842-dcdf02b0d34c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsMember_277b9d20-7ae8-480e-bcd1-d673f2e22e6d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_a78beb7c-b114-40be-b842-dcdf02b0d34c" xlink:to="loc_us-gaap_CashAndCashEquivalentsMember_277b9d20-7ae8-480e-bcd1-d673f2e22e6d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_5454fd31-13a8-4505-ab3d-a302a6cbc980" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_a78beb7c-b114-40be-b842-dcdf02b0d34c" xlink:to="loc_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_5454fd31-13a8-4505-ab3d-a302a6cbc980" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_20338068-658a-45d6-bc8d-ed4fb62a8f51" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_a78beb7c-b114-40be-b842-dcdf02b0d34c" xlink:to="loc_us-gaap_OtherCurrentLiabilitiesMember_20338068-658a-45d6-bc8d-ed4fb62a8f51" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="simple" xlink:href="app-20230331.xsd#FairValueMeasurementsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="extended" id="id633f7ec9701439f8431ead8b6e799f9_FairValueMeasurementsNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_265bf4c4-dc00-4b5f-ba29-81705a78bc21" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnDerivatives_5db968a8-76e2-4fa3-b4a4-4adef72f6c29" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrealizedGainLossOnDerivatives"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_265bf4c4-dc00-4b5f-ba29-81705a78bc21" xlink:to="loc_us-gaap_UnrealizedGainLossOnDerivatives_5db968a8-76e2-4fa3-b4a4-4adef72f6c29" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGain_0cc5878b-d988-49b6-9b38-fd7e2940ac75" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_265bf4c4-dc00-4b5f-ba29-81705a78bc21" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGain_0cc5878b-d988-49b6-9b38-fd7e2940ac75" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_1600e20f-5f83-4a15-95a4-7dcc4fc4a87b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_265bf4c4-dc00-4b5f-ba29-81705a78bc21" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_1600e20f-5f83-4a15-95a4-7dcc4fc4a87b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_InvestmentFundTerm_b226c019-d4c4-4f8b-9086-d975557cbb1c" xlink:href="app-20230331.xsd#app_InvestmentFundTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_265bf4c4-dc00-4b5f-ba29-81705a78bc21" xlink:to="loc_app_InvestmentFundTerm_b226c019-d4c4-4f8b-9086-d975557cbb1c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_InvestmentFundOptionToExtendTerm_81b16d40-00c3-4a39-af9c-496229e97108" xlink:href="app-20230331.xsd#app_InvestmentFundOptionToExtendTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_265bf4c4-dc00-4b5f-ba29-81705a78bc21" xlink:to="loc_app_InvestmentFundOptionToExtendTerm_81b16d40-00c3-4a39-af9c-496229e97108" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_InvestmentFundMaximumExposureLossLimit_6db22e27-4d57-4d73-b094-bcc88d0c6031" xlink:href="app-20230331.xsd#app_InvestmentFundMaximumExposureLossLimit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_265bf4c4-dc00-4b5f-ba29-81705a78bc21" xlink:to="loc_app_InvestmentFundMaximumExposureLossLimit_6db22e27-4d57-4d73-b094-bcc88d0c6031" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_InvestmentFundMaximumExposureLossLimitUnfundedCommitments_f6d620a6-ac41-4997-b707-3ea57823ac97" xlink:href="app-20230331.xsd#app_InvestmentFundMaximumExposureLossLimitUnfundedCommitments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_265bf4c4-dc00-4b5f-ba29-81705a78bc21" xlink:to="loc_app_InvestmentFundMaximumExposureLossLimitUnfundedCommitments_f6d620a6-ac41-4997-b707-3ea57823ac97" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_PurchaseOfNonmarketableInvestments_6b6635e1-c46b-4ff3-b141-2b31396bf3bb" xlink:href="app-20230331.xsd#app_PurchaseOfNonmarketableInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_265bf4c4-dc00-4b5f-ba29-81705a78bc21" xlink:to="loc_app_PurchaseOfNonmarketableInvestments_6b6635e1-c46b-4ff3-b141-2b31396bf3bb" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireOtherInvestments_61a2a0dc-d742-4c2f-8c66-858acc9acce4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireOtherInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_265bf4c4-dc00-4b5f-ba29-81705a78bc21" xlink:to="loc_us-gaap_PaymentsToAcquireOtherInvestments_61a2a0dc-d742-4c2f-8c66-858acc9acce4" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetImpairmentCharges_6d5fad96-507f-4e08-8233-f5ddfdb3658c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetImpairmentCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_265bf4c4-dc00-4b5f-ba29-81705a78bc21" xlink:to="loc_us-gaap_OtherAssetImpairmentCharges_6d5fad96-507f-4e08-8233-f5ddfdb3658c" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent_d1b98aa4-9ea6-486a-9a6f-315a9ee5cc5f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_265bf4c4-dc00-4b5f-ba29-81705a78bc21" xlink:to="loc_us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent_d1b98aa4-9ea6-486a-9a6f-315a9ee5cc5f" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable_92a1afbe-9e00-4927-82c1-8a013f9262a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_265bf4c4-dc00-4b5f-ba29-81705a78bc21" xlink:to="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable_92a1afbe-9e00-4927-82c1-8a013f9262a2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_98d97ab3-4081-4908-bb5e-1eadf1703c59" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable_92a1afbe-9e00-4927-82c1-8a013f9262a2" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_98d97ab3-4081-4908-bb5e-1eadf1703c59" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_98d97ab3-4081-4908-bb5e-1eadf1703c59_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_98d97ab3-4081-4908-bb5e-1eadf1703c59" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_98d97ab3-4081-4908-bb5e-1eadf1703c59_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_9ee8e50b-07cb-428a-b249-deacd2587b43" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_98d97ab3-4081-4908-bb5e-1eadf1703c59" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_9ee8e50b-07cb-428a-b249-deacd2587b43" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasuredAtNetAssetValuePerShareMember_75229431-e62e-47aa-b35f-76abd73276e5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasuredAtNetAssetValuePerShareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_9ee8e50b-07cb-428a-b249-deacd2587b43" xlink:to="loc_us-gaap_FairValueMeasuredAtNetAssetValuePerShareMember_75229431-e62e-47aa-b35f-76abd73276e5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_7ba0a918-4746-4193-9238-a424791288ba" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable_92a1afbe-9e00-4927-82c1-8a013f9262a2" xlink:to="loc_srt_RangeAxis_7ba0a918-4746-4193-9238-a424791288ba" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_7ba0a918-4746-4193-9238-a424791288ba_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_7ba0a918-4746-4193-9238-a424791288ba" xlink:to="loc_srt_RangeMember_7ba0a918-4746-4193-9238-a424791288ba_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_84c973ff-9cf2-4e86-9514-a287aedbe2a1" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_7ba0a918-4746-4193-9238-a424791288ba" xlink:to="loc_srt_RangeMember_84c973ff-9cf2-4e86-9514-a287aedbe2a1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_db87551b-3dc8-4246-9fe1-6bcc298a1364" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_84c973ff-9cf2-4e86-9514-a287aedbe2a1" xlink:to="loc_srt_MinimumMember_db87551b-3dc8-4246-9fe1-6bcc298a1364" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_3f5a3db5-dd7e-42ae-878c-b04044681cbb" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_84c973ff-9cf2-4e86-9514-a287aedbe2a1" xlink:to="loc_srt_MaximumMember_3f5a3db5-dd7e-42ae-878c-b04044681cbb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_08ec8133-5461-4505-ab5c-26bd1e78658d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable_92a1afbe-9e00-4927-82c1-8a013f9262a2" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_08ec8133-5461-4505-ab5c-26bd1e78658d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_08ec8133-5461-4505-ab5c-26bd1e78658d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_08ec8133-5461-4505-ab5c-26bd1e78658d" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_08ec8133-5461-4505-ab5c-26bd1e78658d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_97cea1b3-5bb7-4ac5-99f5-2cc64f164e28" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_08ec8133-5461-4505-ab5c-26bd1e78658d" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_97cea1b3-5bb7-4ac5-99f5-2cc64f164e28" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_9aa0e60f-699e-4aee-8014-e28916f72c0b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_97cea1b3-5bb7-4ac5-99f5-2cc64f164e28" xlink:to="loc_us-gaap_InterestRateSwapMember_9aa0e60f-699e-4aee-8014-e28916f72c0b" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/CommitmentsandContingenciesDetails" xlink:type="simple" xlink:href="app-20230331.xsd#CommitmentsandContingenciesDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/CommitmentsandContingenciesDetails" xlink:type="extended" id="iddf19010f556443da024c86424d5e2d9_CommitmentsandContingenciesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsLineItems_9938e4e9-3f22-4003-89f2-0088a80f3e47" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherCommitmentsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_AmendedContractualObligation_3ddc98bc-70ff-430a-84bf-31cf2931c102" xlink:href="app-20230331.xsd#app_AmendedContractualObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_9938e4e9-3f22-4003-89f2-0088a80f3e47" xlink:to="loc_app_AmendedContractualObligation_3ddc98bc-70ff-430a-84bf-31cf2931c102" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_PaymentsForPurchaseObligations_0d4b58f5-e402-4d31-813b-2a5f7ac191a7" xlink:href="app-20230331.xsd#app_PaymentsForPurchaseObligations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_9938e4e9-3f22-4003-89f2-0088a80f3e47" xlink:to="loc_app_PaymentsForPurchaseObligations_0d4b58f5-e402-4d31-813b-2a5f7ac191a7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_PurchaseCommitmentUnpaidCommitmentAmount_dc75c8f3-6725-4cf7-bb18-78202b422422" xlink:href="app-20230331.xsd#app_PurchaseCommitmentUnpaidCommitmentAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_9938e4e9-3f22-4003-89f2-0088a80f3e47" xlink:to="loc_app_PurchaseCommitmentUnpaidCommitmentAmount_dc75c8f3-6725-4cf7-bb18-78202b422422" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_InvestmentFundMaximumExposureLossLimitUnfundedCommitments_3cd21820-8710-406d-ae32-bdba91d1d9cf" xlink:href="app-20230331.xsd#app_InvestmentFundMaximumExposureLossLimitUnfundedCommitments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_9938e4e9-3f22-4003-89f2-0088a80f3e47" xlink:to="loc_app_InvestmentFundMaximumExposureLossLimitUnfundedCommitments_3cd21820-8710-406d-ae32-bdba91d1d9cf" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_2cda985e-0220-4574-8a6d-b2d3de480358" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LettersOfCreditOutstandingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_9938e4e9-3f22-4003-89f2-0088a80f3e47" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_2cda985e-0220-4574-8a6d-b2d3de480358" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsTable_0cb76e56-90cc-4f47-81b4-17f66d2da1fa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherCommitmentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_9938e4e9-3f22-4003-89f2-0088a80f3e47" xlink:to="loc_us-gaap_OtherCommitmentsTable_0cb76e56-90cc-4f47-81b4-17f66d2da1fa" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseCommitmentExcludingLongtermCommitmentAxis_ae6b8753-089b-4f3d-b47a-1222b1e1b77d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PurchaseCommitmentExcludingLongtermCommitmentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OtherCommitmentsTable_0cb76e56-90cc-4f47-81b4-17f66d2da1fa" xlink:to="loc_us-gaap_PurchaseCommitmentExcludingLongtermCommitmentAxis_ae6b8753-089b-4f3d-b47a-1222b1e1b77d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseCommitmentExcludingLongtermCommitmentDomain_ae6b8753-089b-4f3d-b47a-1222b1e1b77d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PurchaseCommitmentExcludingLongtermCommitmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PurchaseCommitmentExcludingLongtermCommitmentAxis_ae6b8753-089b-4f3d-b47a-1222b1e1b77d" xlink:to="loc_us-gaap_PurchaseCommitmentExcludingLongtermCommitmentDomain_ae6b8753-089b-4f3d-b47a-1222b1e1b77d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseCommitmentExcludingLongtermCommitmentDomain_80c6323e-91b7-4cfe-a168-358042fe7a4b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PurchaseCommitmentExcludingLongtermCommitmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PurchaseCommitmentExcludingLongtermCommitmentAxis_ae6b8753-089b-4f3d-b47a-1222b1e1b77d" xlink:to="loc_us-gaap_PurchaseCommitmentExcludingLongtermCommitmentDomain_80c6323e-91b7-4cfe-a168-358042fe7a4b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrivateEquityFundsMember_94cd9625-44b3-4318-8e4f-127150a9eda6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrivateEquityFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PurchaseCommitmentExcludingLongtermCommitmentDomain_80c6323e-91b7-4cfe-a168-358042fe7a4b" xlink:to="loc_us-gaap_PrivateEquityFundsMember_94cd9625-44b3-4318-8e4f-127150a9eda6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_f90b329b-e099-4153-ae8d-dba7b871d139" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OtherCommitmentsTable_0cb76e56-90cc-4f47-81b4-17f66d2da1fa" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_f90b329b-e099-4153-ae8d-dba7b871d139" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_f90b329b-e099-4153-ae8d-dba7b871d139_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_f90b329b-e099-4153-ae8d-dba7b871d139" xlink:to="loc_us-gaap_LossContingencyNatureDomain_f90b329b-e099-4153-ae8d-dba7b871d139_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_efdd0cd9-041b-41e8-9c93-33512de2b88a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_f90b329b-e099-4153-ae8d-dba7b871d139" xlink:to="loc_us-gaap_LossContingencyNatureDomain_efdd0cd9-041b-41e8-9c93-33512de2b88a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StandbyLettersOfCreditMember_26c1e07b-6adf-4477-8d65-ad536320c2a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StandbyLettersOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_efdd0cd9-041b-41e8-9c93-33512de2b88a" xlink:to="loc_us-gaap_StandbyLettersOfCreditMember_26c1e07b-6adf-4477-8d65-ad536320c2a3" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/AcquisitionsandDispositionsNarrativeDetails" xlink:type="simple" xlink:href="app-20230331.xsd#AcquisitionsandDispositionsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/AcquisitionsandDispositionsNarrativeDetails" xlink:type="extended" id="i4af747817fff4c08a184894ffdb296f3_AcquisitionsandDispositionsNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_240f3ba9-9f45-45ae-b43d-a1662a785b39" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_AssetAcquisitionConsiderationTransferredContingentConsiderationCosts_89e4c813-ea20-4799-9f94-f24255cbb1da" xlink:href="app-20230331.xsd#app_AssetAcquisitionConsiderationTransferredContingentConsiderationCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_240f3ba9-9f45-45ae-b43d-a1662a785b39" xlink:to="loc_app_AssetAcquisitionConsiderationTransferredContingentConsiderationCosts_89e4c813-ea20-4799-9f94-f24255cbb1da" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_5f99adec-0b86-41df-8c48-600e1d7eccae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_240f3ba9-9f45-45ae-b43d-a1662a785b39" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_5f99adec-0b86-41df-8c48-600e1d7eccae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_8a1c0d31-9543-4567-8900-f87bd3b9f166" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_240f3ba9-9f45-45ae-b43d-a1662a785b39" xlink:to="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_8a1c0d31-9543-4567-8900-f87bd3b9f166" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillExpectedTaxDeductibleAmount_1ef2c83c-786f-412e-b27f-6fc307e5f531" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillExpectedTaxDeductibleAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_240f3ba9-9f45-45ae-b43d-a1662a785b39" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillExpectedTaxDeductibleAmount_1ef2c83c-786f-412e-b27f-6fc307e5f531" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_ab1dbf71-b5b0-4aa3-ae4a-354e8116a0c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_240f3ba9-9f45-45ae-b43d-a1662a785b39" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_ab1dbf71-b5b0-4aa3-ae4a-354e8116a0c8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsExpensesAndLossesRecognized_0863e274-cc1b-464b-b249-89b6b38a28b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsExpensesAndLossesRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_240f3ba9-9f45-45ae-b43d-a1662a785b39" xlink:to="loc_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsExpensesAndLossesRecognized_0863e274-cc1b-464b-b249-89b6b38a28b5" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual_f0e3ff34-db28-4207-8e2d-c17de3892164" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_240f3ba9-9f45-45ae-b43d-a1662a785b39" xlink:to="loc_us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual_f0e3ff34-db28-4207-8e2d-c17de3892164" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_37d3a165-93c6-44ce-8343-40b5742b0dba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_240f3ba9-9f45-45ae-b43d-a1662a785b39" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_37d3a165-93c6-44ce-8343-40b5742b0dba" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionAxis_75cdf854-72c3-4425-b309-d9df6eba6e6c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_37d3a165-93c6-44ce-8343-40b5742b0dba" xlink:to="loc_us-gaap_AssetAcquisitionAxis_75cdf854-72c3-4425-b309-d9df6eba6e6c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_75cdf854-72c3-4425-b309-d9df6eba6e6c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AssetAcquisitionAxis_75cdf854-72c3-4425-b309-d9df6eba6e6c" xlink:to="loc_us-gaap_AssetAcquisitionDomain_75cdf854-72c3-4425-b309-d9df6eba6e6c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_e2f20a55-5118-4c41-ae6a-550fe4bae0e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AssetAcquisitionAxis_75cdf854-72c3-4425-b309-d9df6eba6e6c" xlink:to="loc_us-gaap_AssetAcquisitionDomain_e2f20a55-5118-4c41-ae6a-550fe4bae0e0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_AcquisitionOfCertainMobileGameAppsMember_16d62d2f-017c-4f11-a90b-67891f87af9c" xlink:href="app-20230331.xsd#app_AcquisitionOfCertainMobileGameAppsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionDomain_e2f20a55-5118-4c41-ae6a-550fe4bae0e0" xlink:to="loc_app_AcquisitionOfCertainMobileGameAppsMember_16d62d2f-017c-4f11-a90b-67891f87af9c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_AcquistionOfCertainMobileGameAppsMember_89666f63-be6d-4d97-87ec-f6a1bc7f1b0e" xlink:href="app-20230331.xsd#app_AcquistionOfCertainMobileGameAppsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionDomain_e2f20a55-5118-4c41-ae6a-550fe4bae0e0" xlink:to="loc_app_AcquistionOfCertainMobileGameAppsMember_89666f63-be6d-4d97-87ec-f6a1bc7f1b0e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_56444f02-0724-4781-b2b3-aebbdcc3ccff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_37d3a165-93c6-44ce-8343-40b5742b0dba" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_56444f02-0724-4781-b2b3-aebbdcc3ccff" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_56444f02-0724-4781-b2b3-aebbdcc3ccff_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_56444f02-0724-4781-b2b3-aebbdcc3ccff" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_56444f02-0724-4781-b2b3-aebbdcc3ccff_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_f9da04d9-9b53-4577-b1b3-ac28b73def96" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_56444f02-0724-4781-b2b3-aebbdcc3ccff" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_f9da04d9-9b53-4577-b1b3-ac28b73def96" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_MoPubMember_c375306a-4a9d-48d4-a605-8ed1b695b268" xlink:href="app-20230331.xsd#app_MoPubMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_f9da04d9-9b53-4577-b1b3-ac28b73def96" xlink:to="loc_app_MoPubMember_c375306a-4a9d-48d4-a605-8ed1b695b268" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsAxis_f288344e-d29b-469f-b288-ec7cb5d77631" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_37d3a165-93c6-44ce-8343-40b5742b0dba" xlink:to="loc_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsAxis_f288344e-d29b-469f-b288-ec7cb5d77631" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsDomain_f288344e-d29b-469f-b288-ec7cb5d77631_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsAxis_f288344e-d29b-469f-b288-ec7cb5d77631" xlink:to="loc_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsDomain_f288344e-d29b-469f-b288-ec7cb5d77631_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsDomain_4a28cb34-22ec-46d0-a885-077c135ba841" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsAxis_f288344e-d29b-469f-b288-ec7cb5d77631" xlink:to="loc_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsDomain_4a28cb34-22ec-46d0-a885-077c135ba841" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_TransitionalServicesAgreementMember_f18be2cc-66e9-4e38-9635-77f784ae07c8" xlink:href="app-20230331.xsd#app_TransitionalServicesAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsDomain_4a28cb34-22ec-46d0-a885-077c135ba841" xlink:to="loc_app_TransitionalServicesAgreementMember_f18be2cc-66e9-4e38-9635-77f784ae07c8" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/AcquisitionsandDispositionsSummaryoftheFairValueofIdentifiableAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="app-20230331.xsd#AcquisitionsandDispositionsSummaryoftheFairValueofIdentifiableAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/AcquisitionsandDispositionsSummaryoftheFairValueofIdentifiableAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended" id="ide7135a432574ef1b7397d9e3c2de320_AcquisitionsandDispositionsSummaryoftheFairValueofIdentifiableAssetsAcquiredandLiabilitiesAssumedDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_39fb29e8-0216-4f95-a752-68ecdde117fe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_a6768a26-7154-45d6-b811-cb438897ba5b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_39fb29e8-0216-4f95-a752-68ecdde117fe" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_a6768a26-7154-45d6-b811-cb438897ba5b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_cdc4bf9f-625e-43b9-8d58-7bf156c69c35" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_39fb29e8-0216-4f95-a752-68ecdde117fe" xlink:to="loc_us-gaap_Goodwill_cdc4bf9f-625e-43b9-8d58-7bf156c69c35" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_c1c5f865-4aba-4ff0-8e2a-c161df4d7346" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_39fb29e8-0216-4f95-a752-68ecdde117fe" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_c1c5f865-4aba-4ff0-8e2a-c161df4d7346" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_4fe9b52e-e644-48f2-82d3-610c20932b1a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_39fb29e8-0216-4f95-a752-68ecdde117fe" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_4fe9b52e-e644-48f2-82d3-610c20932b1a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_406a9ef9-ee64-4c81-bb08-3095af9cd040" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_39fb29e8-0216-4f95-a752-68ecdde117fe" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_406a9ef9-ee64-4c81-bb08-3095af9cd040" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_1c9862c0-f765-4f5c-8ffe-2e142c786fe3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_406a9ef9-ee64-4c81-bb08-3095af9cd040" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_1c9862c0-f765-4f5c-8ffe-2e142c786fe3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_1c9862c0-f765-4f5c-8ffe-2e142c786fe3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_1c9862c0-f765-4f5c-8ffe-2e142c786fe3" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_1c9862c0-f765-4f5c-8ffe-2e142c786fe3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2b5d647b-7df2-4654-95f3-303f5b4390dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_1c9862c0-f765-4f5c-8ffe-2e142c786fe3" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2b5d647b-7df2-4654-95f3-303f5b4390dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_MoPubMember_51791a7e-4271-43e5-b406-15ef66273141" xlink:href="app-20230331.xsd#app_MoPubMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2b5d647b-7df2-4654-95f3-303f5b4390dc" xlink:to="loc_app_MoPubMember_51791a7e-4271-43e5-b406-15ef66273141" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_5de640fa-2263-4f50-b70b-fb5d4b9269ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_406a9ef9-ee64-4c81-bb08-3095af9cd040" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_5de640fa-2263-4f50-b70b-fb5d4b9269ff" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5de640fa-2263-4f50-b70b-fb5d4b9269ff_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_5de640fa-2263-4f50-b70b-fb5d4b9269ff" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5de640fa-2263-4f50-b70b-fb5d4b9269ff_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ec54e4ac-c87b-4ce1-9773-d27c8e735ba4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_5de640fa-2263-4f50-b70b-fb5d4b9269ff" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ec54e4ac-c87b-4ce1-9773-d27c8e735ba4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_AdvertiserRelationshipsMember_9ca0d34d-f37f-421a-a331-dad64e5277a4" xlink:href="app-20230331.xsd#app_AdvertiserRelationshipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ec54e4ac-c87b-4ce1-9773-d27c8e735ba4" xlink:to="loc_app_AdvertiserRelationshipsMember_9ca0d34d-f37f-421a-a331-dad64e5277a4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_PublisherRelationshipsMember_038b85ab-efdb-4486-837c-005edd101b7f" xlink:href="app-20230331.xsd#app_PublisherRelationshipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ec54e4ac-c87b-4ce1-9773-d27c8e735ba4" xlink:to="loc_app_PublisherRelationshipsMember_038b85ab-efdb-4486-837c-005edd101b7f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_f01b6df6-55af-4e17-9729-24e4e78d276b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DevelopedTechnologyRightsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ec54e4ac-c87b-4ce1-9773-d27c8e735ba4" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_f01b6df6-55af-4e17-9729-24e4e78d276b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradeNamesMember_185461ef-3a27-400c-ac62-5cece54c646d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TradeNamesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ec54e4ac-c87b-4ce1-9773-d27c8e735ba4" xlink:to="loc_us-gaap_TradeNamesMember_185461ef-3a27-400c-ac62-5cece54c646d" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/AcquisitionsandDispositionsProFormaAdjustmentstoNetIncomeLossDetails" xlink:type="simple" xlink:href="app-20230331.xsd#AcquisitionsandDispositionsProFormaAdjustmentstoNetIncomeLossDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/AcquisitionsandDispositionsProFormaAdjustmentstoNetIncomeLossDetails" xlink:type="extended" id="i0e1425ba96ec4922b02734e841ec59f7_AcquisitionsandDispositionsProFormaAdjustmentstoNetIncomeLossDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionProFormaInformationNonrecurringAdjustmentLineItems_7093da1c-2b8c-4357-a5a8-dd36bf182cda" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionProFormaInformationNonrecurringAdjustmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_c648278c-f1b4-494c-a4a0-9ce62dcc2945" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionProFormaInformationNonrecurringAdjustmentLineItems_7093da1c-2b8c-4357-a5a8-dd36bf182cda" xlink:to="loc_us-gaap_BusinessAcquisitionsProFormaNetIncomeLoss_c648278c-f1b4-494c-a4a0-9ce62dcc2945" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionProFormaInformationNonrecurringAdjustmentsTable_0874ca3d-caff-4d1e-bb47-26470e9dd850" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionProFormaInformationNonrecurringAdjustmentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionProFormaInformationNonrecurringAdjustmentLineItems_7093da1c-2b8c-4357-a5a8-dd36bf182cda" xlink:to="loc_us-gaap_BusinessAcquisitionProFormaInformationNonrecurringAdjustmentsTable_0874ca3d-caff-4d1e-bb47-26470e9dd850" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonrecurringAdjustmentAxis_2e8b6b07-810c-4809-8c69-295528919216" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonrecurringAdjustmentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_BusinessAcquisitionProFormaInformationNonrecurringAdjustmentsTable_0874ca3d-caff-4d1e-bb47-26470e9dd850" xlink:to="loc_us-gaap_NonrecurringAdjustmentAxis_2e8b6b07-810c-4809-8c69-295528919216" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonrecurringAdjustmentDomain_2e8b6b07-810c-4809-8c69-295528919216_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonrecurringAdjustmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_NonrecurringAdjustmentAxis_2e8b6b07-810c-4809-8c69-295528919216" xlink:to="loc_us-gaap_NonrecurringAdjustmentDomain_2e8b6b07-810c-4809-8c69-295528919216_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonrecurringAdjustmentDomain_c5188dec-852c-41f1-a142-08026e93589e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonrecurringAdjustmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_NonrecurringAdjustmentAxis_2e8b6b07-810c-4809-8c69-295528919216" xlink:to="loc_us-gaap_NonrecurringAdjustmentDomain_c5188dec-852c-41f1-a142-08026e93589e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_AmortizationExpenseMember_8304a1cf-2952-4065-916f-7e0a44176687" xlink:href="app-20230331.xsd#app_AmortizationExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonrecurringAdjustmentDomain_c5188dec-852c-41f1-a142-08026e93589e" xlink:to="loc_app_AmortizationExpenseMember_8304a1cf-2952-4065-916f-7e0a44176687" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_TransitionalServiceAgreementMember_a56451e6-b9a1-4ce6-9a05-f7814267d139" xlink:href="app-20230331.xsd#app_TransitionalServiceAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonrecurringAdjustmentDomain_c5188dec-852c-41f1-a142-08026e93589e" xlink:to="loc_app_TransitionalServiceAgreementMember_a56451e6-b9a1-4ce6-9a05-f7814267d139" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquisitionRelatedCostsMember_d2f232bd-4844-4f99-8109-4ac721cb7bce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AcquisitionRelatedCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonrecurringAdjustmentDomain_c5188dec-852c-41f1-a142-08026e93589e" xlink:to="loc_us-gaap_AcquisitionRelatedCostsMember_d2f232bd-4844-4f99-8109-4ac721cb7bce" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_DecreaseIncreaseToIncomeTaxProvisionMember_b43032ae-04ae-42e9-a8b4-ab4cd5b90e86" xlink:href="app-20230331.xsd#app_DecreaseIncreaseToIncomeTaxProvisionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NonrecurringAdjustmentDomain_c5188dec-852c-41f1-a142-08026e93589e" xlink:to="loc_app_DecreaseIncreaseToIncomeTaxProvisionMember_b43032ae-04ae-42e9-a8b4-ab4cd5b90e86" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/GoodwillandIntangibleAssetsSummaryofGoodwillActivityDetails" xlink:type="simple" xlink:href="app-20230331.xsd#GoodwillandIntangibleAssetsSummaryofGoodwillActivityDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/GoodwillandIntangibleAssetsSummaryofGoodwillActivityDetails" xlink:type="extended" id="ia9a30a18d2f54c519ba5092d1c99cc4b_GoodwillandIntangibleAssetsSummaryofGoodwillActivityDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_0b6d9101-75f7-47e4-af9d-9082f1a3cdda" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillRollForward_82c7722f-8e00-4b15-813c-74ec34e1df6b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_0b6d9101-75f7-47e4-af9d-9082f1a3cdda" xlink:to="loc_us-gaap_GoodwillRollForward_82c7722f-8e00-4b15-813c-74ec34e1df6b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_901e144c-93c8-4d6f-9b39-3bea1f4278bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_82c7722f-8e00-4b15-813c-74ec34e1df6b" xlink:to="loc_us-gaap_Goodwill_901e144c-93c8-4d6f-9b39-3bea1f4278bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAcquiredDuringPeriod_faf27fbc-0bd1-4788-8df5-9811079a30ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillAcquiredDuringPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_82c7722f-8e00-4b15-813c-74ec34e1df6b" xlink:to="loc_us-gaap_GoodwillAcquiredDuringPeriod_faf27fbc-0bd1-4788-8df5-9811079a30ca" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_b6a734d8-fe2b-439f-9ed8-aed80c759a30" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillForeignCurrencyTranslationGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_82c7722f-8e00-4b15-813c-74ec34e1df6b" xlink:to="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_b6a734d8-fe2b-439f-9ed8-aed80c759a30" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_1eb7b389-f0ef-448d-a369-b07978eb0f9a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_8e17b337-f988-46ad-93bb-bfa1871eff17" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_0b6d9101-75f7-47e4-af9d-9082f1a3cdda" xlink:to="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_8e17b337-f988-46ad-93bb-bfa1871eff17" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_54730ea8-1d1b-4079-a0ad-dbd5a76e463c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_8e17b337-f988-46ad-93bb-bfa1871eff17" xlink:to="loc_srt_ConsolidationItemsAxis_54730ea8-1d1b-4079-a0ad-dbd5a76e463c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_54730ea8-1d1b-4079-a0ad-dbd5a76e463c_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_54730ea8-1d1b-4079-a0ad-dbd5a76e463c" xlink:to="loc_srt_ConsolidationItemsDomain_54730ea8-1d1b-4079-a0ad-dbd5a76e463c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_877c0fce-61cc-4382-ac3c-7c35d8e4154a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_54730ea8-1d1b-4079-a0ad-dbd5a76e463c" xlink:to="loc_srt_ConsolidationItemsDomain_877c0fce-61cc-4382-ac3c-7c35d8e4154a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_aa29c547-709d-4ae9-9fff-35c9e148215f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_877c0fce-61cc-4382-ac3c-7c35d8e4154a" xlink:to="loc_us-gaap_OperatingSegmentsMember_aa29c547-709d-4ae9-9fff-35c9e148215f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_7a8d1edb-9d3a-4777-bfe9-cfd451599b23" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_8e17b337-f988-46ad-93bb-bfa1871eff17" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_7a8d1edb-9d3a-4777-bfe9-cfd451599b23" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_7a8d1edb-9d3a-4777-bfe9-cfd451599b23_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_7a8d1edb-9d3a-4777-bfe9-cfd451599b23" xlink:to="loc_us-gaap_SegmentDomain_7a8d1edb-9d3a-4777-bfe9-cfd451599b23_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_bbd13630-20cf-4c9a-816f-369db9ae9203" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_7a8d1edb-9d3a-4777-bfe9-cfd451599b23" xlink:to="loc_us-gaap_SegmentDomain_bbd13630-20cf-4c9a-816f-369db9ae9203" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_BusinessRevenueSoftwarePlatformMember_8c0b8124-78f2-4435-bdb3-6552718a171a" xlink:href="app-20230331.xsd#app_BusinessRevenueSoftwarePlatformMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_bbd13630-20cf-4c9a-816f-369db9ae9203" xlink:to="loc_app_BusinessRevenueSoftwarePlatformMember_8c0b8124-78f2-4435-bdb3-6552718a171a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_AppsMember_b06c1d18-2763-483b-ad67-8ce87e78e052" xlink:href="app-20230331.xsd#app_AppsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_bbd13630-20cf-4c9a-816f-369db9ae9203" xlink:to="loc_app_AppsMember_b06c1d18-2763-483b-ad67-8ce87e78e052" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/GoodwillandIntangibleAssetsSummaryofIntangibleAssetsAcquiredNetDetails" xlink:type="simple" xlink:href="app-20230331.xsd#GoodwillandIntangibleAssetsSummaryofIntangibleAssetsAcquiredNetDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/GoodwillandIntangibleAssetsSummaryofIntangibleAssetsAcquiredNetDetails" xlink:type="extended" id="ia12cb2c73e394500a3cf60907065c1bc_GoodwillandIntangibleAssetsSummaryofIntangibleAssetsAcquiredNetDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_710c945c-c527-47a1-92ee-58f90f17d4c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_0314876e-6f09-4e85-9ced-0bc27e3c7a51" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_710c945c-c527-47a1-92ee-58f90f17d4c7" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_0314876e-6f09-4e85-9ced-0bc27e3c7a51" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_fb98fb09-d152-4834-8b4e-e12ac33972c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_710c945c-c527-47a1-92ee-58f90f17d4c7" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_fb98fb09-d152-4834-8b4e-e12ac33972c7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_203b13e2-76fa-4bc1-863e-76326438c6dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_710c945c-c527-47a1-92ee-58f90f17d4c7" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_203b13e2-76fa-4bc1-863e-76326438c6dc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_4120b7b7-2736-445c-9892-cbd466e02a4e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_710c945c-c527-47a1-92ee-58f90f17d4c7" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_4120b7b7-2736-445c-9892-cbd466e02a4e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_705a8e07-e79c-4c11-ada6-ab4abff94023" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_710c945c-c527-47a1-92ee-58f90f17d4c7" xlink:to="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_705a8e07-e79c-4c11-ada6-ab4abff94023" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_f06bacb4-e2f9-43ea-9d8e-b4e38ab89783" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_705a8e07-e79c-4c11-ada6-ab4abff94023" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_f06bacb4-e2f9-43ea-9d8e-b4e38ab89783" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_f06bacb4-e2f9-43ea-9d8e-b4e38ab89783_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_f06bacb4-e2f9-43ea-9d8e-b4e38ab89783" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_f06bacb4-e2f9-43ea-9d8e-b4e38ab89783_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5b225da3-dbea-4e32-b5d6-5acb64ab846f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_f06bacb4-e2f9-43ea-9d8e-b4e38ab89783" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5b225da3-dbea-4e32-b5d6-5acb64ab846f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_AppsMember_40a7bee1-bde5-4b97-8ac9-88d5cb745881" xlink:href="app-20230331.xsd#app_AppsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5b225da3-dbea-4e32-b5d6-5acb64ab846f" xlink:to="loc_app_AppsMember_40a7bee1-bde5-4b97-8ac9-88d5cb745881" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerRelationshipsMember_e7fb4491-92ca-4c5e-900b-8e8c1a4f3d09" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CustomerRelationshipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5b225da3-dbea-4e32-b5d6-5acb64ab846f" xlink:to="loc_us-gaap_CustomerRelationshipsMember_e7fb4491-92ca-4c5e-900b-8e8c1a4f3d09" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_UserBaseMember_3d602562-0853-46d3-954d-15623610df6a" xlink:href="app-20230331.xsd#app_UserBaseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5b225da3-dbea-4e32-b5d6-5acb64ab846f" xlink:to="loc_app_UserBaseMember_3d602562-0853-46d3-954d-15623610df6a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_LicenseAssetMember_fe1724ef-b8cd-46d0-aab4-ecbe8ad8995d" xlink:href="app-20230331.xsd#app_LicenseAssetMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5b225da3-dbea-4e32-b5d6-5acb64ab846f" xlink:to="loc_app_LicenseAssetMember_fe1724ef-b8cd-46d0-aab4-ecbe8ad8995d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_DevelopedTechnologyMember_36869418-c18e-49b8-b800-8a599c188b9c" xlink:href="app-20230331.xsd#app_DevelopedTechnologyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5b225da3-dbea-4e32-b5d6-5acb64ab846f" xlink:to="loc_app_DevelopedTechnologyMember_36869418-c18e-49b8-b800-8a599c188b9c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_OtherMember_f58c733a-052d-4aff-b764-bd46f5046155" xlink:href="app-20230331.xsd#app_OtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_5b225da3-dbea-4e32-b5d6-5acb64ab846f" xlink:to="loc_app_OtherMember_f58c733a-052d-4aff-b764-bd46f5046155" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_e0d01cb1-6e0d-4343-a99d-e1d5f9775f4e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByAssetClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_705a8e07-e79c-4c11-ada6-ab4abff94023" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_e0d01cb1-6e0d-4343-a99d-e1d5f9775f4e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_e0d01cb1-6e0d-4343-a99d-e1d5f9775f4e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_e0d01cb1-6e0d-4343-a99d-e1d5f9775f4e" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_e0d01cb1-6e0d-4343-a99d-e1d5f9775f4e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_aa56b5c7-192f-4a05-8be1-46555680f829" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_e0d01cb1-6e0d-4343-a99d-e1d5f9775f4e" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_aa56b5c7-192f-4a05-8be1-46555680f829" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_LongLivedIntangibleAssetsMember_986ae31e-8bb2-42bd-8dd1-5a670ca41eae" xlink:href="app-20230331.xsd#app_LongLivedIntangibleAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_aa56b5c7-192f-4a05-8be1-46555680f829" xlink:to="loc_app_LongLivedIntangibleAssetsMember_986ae31e-8bb2-42bd-8dd1-5a670ca41eae" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_ShortLivedIntangibleAssetsMember_977ff0d7-e014-42ac-bb31-a60d7020e019" xlink:href="app-20230331.xsd#app_ShortLivedIntangibleAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_aa56b5c7-192f-4a05-8be1-46555680f829" xlink:to="loc_app_ShortLivedIntangibleAssetsMember_977ff0d7-e014-42ac-bb31-a60d7020e019" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_ShortAndLongLivedIntangibleAssetsMember_b4f0bf56-edcb-4c2e-bf84-35f5d1d4b771" xlink:href="app-20230331.xsd#app_ShortAndLongLivedIntangibleAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_aa56b5c7-192f-4a05-8be1-46555680f829" xlink:to="loc_app_ShortAndLongLivedIntangibleAssetsMember_b4f0bf56-edcb-4c2e-bf84-35f5d1d4b771" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/GoodwillandIntangibleAssetsSummaryofFiniteLivedIntangibleAssetsAmortizationExpensesDetails" xlink:type="simple" xlink:href="app-20230331.xsd#GoodwillandIntangibleAssetsSummaryofFiniteLivedIntangibleAssetsAmortizationExpensesDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/GoodwillandIntangibleAssetsSummaryofFiniteLivedIntangibleAssetsAmortizationExpensesDetails" xlink:type="extended" id="i96c79e23b1ea45e5a4d95d09859429f5_GoodwillandIntangibleAssetsSummaryofFiniteLivedIntangibleAssetsAmortizationExpensesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_1a7e7341-1d71-4b08-b579-62affd62b89f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_5ca50d97-c132-4117-b27c-3a501728a07f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_1a7e7341-1d71-4b08-b579-62affd62b89f" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_5ca50d97-c132-4117-b27c-3a501728a07f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_11c70dcc-1972-4e4d-bed8-32b5477c2b10" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_1a7e7341-1d71-4b08-b579-62affd62b89f" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_11c70dcc-1972-4e4d-bed8-32b5477c2b10" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_ff613983-2a33-4e7e-a0d2-13f25b139113" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_11c70dcc-1972-4e4d-bed8-32b5477c2b10" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_ff613983-2a33-4e7e-a0d2-13f25b139113" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_ff613983-2a33-4e7e-a0d2-13f25b139113_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_ff613983-2a33-4e7e-a0d2-13f25b139113" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_ff613983-2a33-4e7e-a0d2-13f25b139113_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_6a325c8e-54ba-4db0-b37b-92cd4faeef08" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_ff613983-2a33-4e7e-a0d2-13f25b139113" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_6a325c8e-54ba-4db0-b37b-92cd4faeef08" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_ba8d3ba6-8310-421c-9aac-0e02baca6d8d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfSalesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_6a325c8e-54ba-4db0-b37b-92cd4faeef08" xlink:to="loc_us-gaap_CostOfSalesMember_ba8d3ba6-8310-421c-9aac-0e02baca6d8d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpenseMember_0c97d3e6-f928-44e2-9942-1ba4527a03e6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingAndMarketingExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_6a325c8e-54ba-4db0-b37b-92cd4faeef08" xlink:to="loc_us-gaap_SellingAndMarketingExpenseMember_0c97d3e6-f928-44e2-9942-1ba4527a03e6" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/EquityDetails" xlink:type="simple" xlink:href="app-20230331.xsd#EquityDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/EquityDetails" xlink:type="extended" id="ie2322f0c9c184d7d95afa1a583ce9ab5_EquityDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_34036f5e-5df3-4b1f-93c3-e6ff484ebc09" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_a1a0c297-c704-4bda-be15-4e3250677895" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_34036f5e-5df3-4b1f-93c3-e6ff484ebc09" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_a1a0c297-c704-4bda-be15-4e3250677895" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_acd0489f-68b0-4f4a-850a-8ed8369b21d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_34036f5e-5df3-4b1f-93c3-e6ff484ebc09" xlink:to="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_acd0489f-68b0-4f4a-850a-8ed8369b21d3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_5904db99-dd69-4c84-96da-751136d8de6a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_34036f5e-5df3-4b1f-93c3-e6ff484ebc09" xlink:to="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_5904db99-dd69-4c84-96da-751136d8de6a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_6e3dc9dc-3bc0-48ce-97a0-efcc446a3ad3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_34036f5e-5df3-4b1f-93c3-e6ff484ebc09" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_6e3dc9dc-3bc0-48ce-97a0-efcc446a3ad3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_d432435a-e86f-49a7-a040-3e0198cb8faa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_6e3dc9dc-3bc0-48ce-97a0-efcc446a3ad3" xlink:to="loc_us-gaap_StatementClassOfStockAxis_d432435a-e86f-49a7-a040-3e0198cb8faa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_d432435a-e86f-49a7-a040-3e0198cb8faa_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_d432435a-e86f-49a7-a040-3e0198cb8faa" xlink:to="loc_us-gaap_ClassOfStockDomain_d432435a-e86f-49a7-a040-3e0198cb8faa_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_fd71a849-6f62-4bdc-8a46-80bd1825012f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_d432435a-e86f-49a7-a040-3e0198cb8faa" xlink:to="loc_us-gaap_ClassOfStockDomain_fd71a849-6f62-4bdc-8a46-80bd1825012f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_de5b40a9-f589-4ba2-bcee-cfeedf46e520" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_fd71a849-6f62-4bdc-8a46-80bd1825012f" xlink:to="loc_us-gaap_CommonClassAMember_de5b40a9-f589-4ba2-bcee-cfeedf46e520" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/StockbasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="app-20230331.xsd#StockbasedCompensationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/StockbasedCompensationNarrativeDetails" xlink:type="extended" id="i32e8707efb474d93a7178fb208502e63_StockbasedCompensationNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9595ca4c-ad0a-4186-89d5-02460d312e99" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_972e894f-305b-48ee-935d-1c40fe426f30" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9595ca4c-ad0a-4186-89d5-02460d312e99" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_972e894f-305b-48ee-935d-1c40fe426f30" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_c0217c70-9258-4078-af3f-30f89e3dd249" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9595ca4c-ad0a-4186-89d5-02460d312e99" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_c0217c70-9258-4078-af3f-30f89e3dd249" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_NumberOfVestingEligibleTraches_980515c0-aaaf-4c15-b4e5-79c03c4ccbfe" xlink:href="app-20230331.xsd#app_NumberOfVestingEligibleTraches"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9595ca4c-ad0a-4186-89d5-02460d312e99" xlink:to="loc_app_NumberOfVestingEligibleTraches_980515c0-aaaf-4c15-b4e5-79c03c4ccbfe" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_NumberOfConsecutiveTradingDay_26e8e317-7d64-4d9c-9882-b687eea4114a" xlink:href="app-20230331.xsd#app_NumberOfConsecutiveTradingDay"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9595ca4c-ad0a-4186-89d5-02460d312e99" xlink:to="loc_app_NumberOfConsecutiveTradingDay_26e8e317-7d64-4d9c-9882-b687eea4114a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformancePeriod_347b6b1a-855c-4ea6-b9ea-4b3ac2519d58" xlink:href="app-20230331.xsd#app_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformancePeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9595ca4c-ad0a-4186-89d5-02460d312e99" xlink:to="loc_app_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformancePeriod_347b6b1a-855c-4ea6-b9ea-4b3ac2519d58" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_9d89b912-43b7-4c23-9aca-87c31902216a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9595ca4c-ad0a-4186-89d5-02460d312e99" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_9d89b912-43b7-4c23-9aca-87c31902216a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_NumberOfVestingTraches_a176f4a6-3217-4d8d-aa90-debc71964ef7" xlink:href="app-20230331.xsd#app_NumberOfVestingTraches"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9595ca4c-ad0a-4186-89d5-02460d312e99" xlink:to="loc_app_NumberOfVestingTraches_a176f4a6-3217-4d8d-aa90-debc71964ef7" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardHoldingPeriod_d484bc8d-bdd7-4fb6-b739-55a9a726b1f3" xlink:href="app-20230331.xsd#app_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardHoldingPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9595ca4c-ad0a-4186-89d5-02460d312e99" xlink:to="loc_app_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardHoldingPeriod_d484bc8d-bdd7-4fb6-b739-55a9a726b1f3" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_f87c4199-be55-441f-ac42-82005e9e457b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9595ca4c-ad0a-4186-89d5-02460d312e99" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_f87c4199-be55-441f-ac42-82005e9e457b" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_e16fd3fd-c930-42e7-86b1-2e72bc547e06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9595ca4c-ad0a-4186-89d5-02460d312e99" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_e16fd3fd-c930-42e7-86b1-2e72bc547e06" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_c9f98f87-ec14-4eec-8c05-feaffd710155" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9595ca4c-ad0a-4186-89d5-02460d312e99" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_c9f98f87-ec14-4eec-8c05-feaffd710155" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_ca02691b-c423-47cd-a6e8-1a99902b92e7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9595ca4c-ad0a-4186-89d5-02460d312e99" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_ca02691b-c423-47cd-a6e8-1a99902b92e7" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_dda73b35-3d60-4728-a999-8e43e908b5fe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_9595ca4c-ad0a-4186-89d5-02460d312e99" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_dda73b35-3d60-4728-a999-8e43e908b5fe" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_b3809c0b-e95a-4318-955f-f3410bba1a55" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_dda73b35-3d60-4728-a999-8e43e908b5fe" xlink:to="loc_us-gaap_PlanNameAxis_b3809c0b-e95a-4318-955f-f3410bba1a55" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_b3809c0b-e95a-4318-955f-f3410bba1a55_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_b3809c0b-e95a-4318-955f-f3410bba1a55" xlink:to="loc_us-gaap_PlanNameDomain_b3809c0b-e95a-4318-955f-f3410bba1a55_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_c4a01ce6-69b6-4f8a-b38c-6fb3f0fa508b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_b3809c0b-e95a-4318-955f-f3410bba1a55" xlink:to="loc_us-gaap_PlanNameDomain_c4a01ce6-69b6-4f8a-b38c-6fb3f0fa508b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_PSUGrantsMember_ae56349c-906d-416d-84ff-74da381b1923" xlink:href="app-20230331.xsd#app_PSUGrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_c4a01ce6-69b6-4f8a-b38c-6fb3f0fa508b" xlink:to="loc_app_PSUGrantsMember_ae56349c-906d-416d-84ff-74da381b1923" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_81b909f4-5eca-4d9b-95b3-b43ded31b8f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_dda73b35-3d60-4728-a999-8e43e908b5fe" xlink:to="loc_us-gaap_StatementClassOfStockAxis_81b909f4-5eca-4d9b-95b3-b43ded31b8f0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_81b909f4-5eca-4d9b-95b3-b43ded31b8f0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_81b909f4-5eca-4d9b-95b3-b43ded31b8f0" xlink:to="loc_us-gaap_ClassOfStockDomain_81b909f4-5eca-4d9b-95b3-b43ded31b8f0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_8397e356-34b3-45d8-81c1-881a000df102" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_81b909f4-5eca-4d9b-95b3-b43ded31b8f0" xlink:to="loc_us-gaap_ClassOfStockDomain_8397e356-34b3-45d8-81c1-881a000df102" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_2802f076-4cfd-48e7-900b-261c1fc09947" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_8397e356-34b3-45d8-81c1-881a000df102" xlink:to="loc_us-gaap_CommonClassAMember_2802f076-4cfd-48e7-900b-261c1fc09947" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_b0ad8c18-ad38-4fa6-b20b-0e7b3b255931" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_dda73b35-3d60-4728-a999-8e43e908b5fe" xlink:to="loc_srt_RangeAxis_b0ad8c18-ad38-4fa6-b20b-0e7b3b255931" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_b0ad8c18-ad38-4fa6-b20b-0e7b3b255931_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_b0ad8c18-ad38-4fa6-b20b-0e7b3b255931" xlink:to="loc_srt_RangeMember_b0ad8c18-ad38-4fa6-b20b-0e7b3b255931_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_5417f54b-db49-49a9-aaf8-a60499083b5f" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_b0ad8c18-ad38-4fa6-b20b-0e7b3b255931" xlink:to="loc_srt_RangeMember_5417f54b-db49-49a9-aaf8-a60499083b5f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_3755bc53-8946-4d47-8e9b-c2633f7ffe6c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_5417f54b-db49-49a9-aaf8-a60499083b5f" xlink:to="loc_srt_MinimumMember_3755bc53-8946-4d47-8e9b-c2633f7ffe6c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_b402b36e-dd2e-4037-89d7-d7fa8de25688" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_5417f54b-db49-49a9-aaf8-a60499083b5f" xlink:to="loc_srt_MaximumMember_b402b36e-dd2e-4037-89d7-d7fa8de25688" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_34d4a424-db0d-466f-9499-9440ad8f5fca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_dda73b35-3d60-4728-a999-8e43e908b5fe" xlink:to="loc_us-gaap_AwardTypeAxis_34d4a424-db0d-466f-9499-9440ad8f5fca" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_34d4a424-db0d-466f-9499-9440ad8f5fca_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_34d4a424-db0d-466f-9499-9440ad8f5fca" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_34d4a424-db0d-466f-9499-9440ad8f5fca_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_58028d67-f91d-4d20-80af-665690e8e92a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_34d4a424-db0d-466f-9499-9440ad8f5fca" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_58028d67-f91d-4d20-80af-665690e8e92a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_3fd3fb12-0d76-45f7-a64b-a0b5c4e2ceab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_58028d67-f91d-4d20-80af-665690e8e92a" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_3fd3fb12-0d76-45f7-a64b-a0b5c4e2ceab" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_96c9146b-0068-4c63-8867-f9d54e26e366" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PerformanceSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_58028d67-f91d-4d20-80af-665690e8e92a" xlink:to="loc_us-gaap_PerformanceSharesMember_96c9146b-0068-4c63-8867-f9d54e26e366" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_6e4f3a1a-5f95-40b0-80fe-fddffb87f29b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_dda73b35-3d60-4728-a999-8e43e908b5fe" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_6e4f3a1a-5f95-40b0-80fe-fddffb87f29b" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_6e4f3a1a-5f95-40b0-80fe-fddffb87f29b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_6e4f3a1a-5f95-40b0-80fe-fddffb87f29b" xlink:to="loc_us-gaap_RelatedPartyDomain_6e4f3a1a-5f95-40b0-80fe-fddffb87f29b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_70642413-e2e6-4523-bb29-d3417733c496" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_6e4f3a1a-5f95-40b0-80fe-fddffb87f29b" xlink:to="loc_us-gaap_RelatedPartyDomain_70642413-e2e6-4523-bb29-d3417733c496" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_AdamForoughiMember_9654e509-7ca2-4bc2-9d1b-f3b65cbc78aa" xlink:href="app-20230331.xsd#app_AdamForoughiMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_70642413-e2e6-4523-bb29-d3417733c496" xlink:to="loc_app_AdamForoughiMember_9654e509-7ca2-4bc2-9d1b-f3b65cbc78aa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_VasilyShikinMember_ae297b7f-28d3-4c5b-b886-30f096914c54" xlink:href="app-20230331.xsd#app_VasilyShikinMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_70642413-e2e6-4523-bb29-d3417733c496" xlink:to="loc_app_VasilyShikinMember_ae297b7f-28d3-4c5b-b886-30f096914c54" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualAxis_3019a05d-48c5-4a57-8c67-c21927e6ca27" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_dda73b35-3d60-4728-a999-8e43e908b5fe" xlink:to="loc_srt_TitleOfIndividualAxis_3019a05d-48c5-4a57-8c67-c21927e6ca27" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_3019a05d-48c5-4a57-8c67-c21927e6ca27_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_TitleOfIndividualAxis_3019a05d-48c5-4a57-8c67-c21927e6ca27" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_3019a05d-48c5-4a57-8c67-c21927e6ca27_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_5d79e43c-7f31-49ab-aede-7d0f9d8c5bd0" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_TitleOfIndividualAxis_3019a05d-48c5-4a57-8c67-c21927e6ca27" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_5d79e43c-7f31-49ab-aede-7d0f9d8c5bd0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ChiefExecutiveOfficerMember_f691acf4-ce68-449e-8383-780eeab8376b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ChiefExecutiveOfficerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_5d79e43c-7f31-49ab-aede-7d0f9d8c5bd0" xlink:to="loc_srt_ChiefExecutiveOfficerMember_f691acf4-ce68-449e-8383-780eeab8376b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_ChiefTreasuryOfficersMember_cdc80f80-0ee4-4501-84d0-554c10af6eb9" xlink:href="app-20230331.xsd#app_ChiefTreasuryOfficersMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_5d79e43c-7f31-49ab-aede-7d0f9d8c5bd0" xlink:to="loc_app_ChiefTreasuryOfficersMember_cdc80f80-0ee4-4501-84d0-554c10af6eb9" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/StockbasedCompensationSummaryofStockbasedPaymentArrangementExpensesDetails" xlink:type="simple" xlink:href="app-20230331.xsd#StockbasedCompensationSummaryofStockbasedPaymentArrangementExpensesDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/StockbasedCompensationSummaryofStockbasedPaymentArrangementExpensesDetails" xlink:type="extended" id="ieae998b993d647b1b296a2d72afe4e9e_StockbasedCompensationSummaryofStockbasedPaymentArrangementExpensesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_6dad4274-12dc-4338-a0d3-645033703932" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_9217df7a-d07f-40b2-9f36-d064243debbf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_6dad4274-12dc-4338-a0d3-645033703932" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_9217df7a-d07f-40b2-9f36-d064243debbf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_6e2dd448-59e4-401d-9fcb-9fde54714e47" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_6dad4274-12dc-4338-a0d3-645033703932" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_6e2dd448-59e4-401d-9fcb-9fde54714e47" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_fa92d4a9-51bb-4df4-98ac-40489e3386f9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_6e2dd448-59e4-401d-9fcb-9fde54714e47" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_fa92d4a9-51bb-4df4-98ac-40489e3386f9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_fa92d4a9-51bb-4df4-98ac-40489e3386f9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_fa92d4a9-51bb-4df4-98ac-40489e3386f9" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_fa92d4a9-51bb-4df4-98ac-40489e3386f9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_22bddd68-9e2e-41fa-b97c-b9bb734e7deb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_fa92d4a9-51bb-4df4-98ac-40489e3386f9" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_22bddd68-9e2e-41fa-b97c-b9bb734e7deb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_CostOfRevenueMember_737918b9-0930-4912-a03c-f9d0ac4986e8" xlink:href="app-20230331.xsd#app_CostOfRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_22bddd68-9e2e-41fa-b97c-b9bb734e7deb" xlink:to="loc_app_CostOfRevenueMember_737918b9-0930-4912-a03c-f9d0ac4986e8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_SalesAndMarketingMember_66848128-df55-451c-9578-97464ed20be9" xlink:href="app-20230331.xsd#app_SalesAndMarketingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_22bddd68-9e2e-41fa-b97c-b9bb734e7deb" xlink:to="loc_app_SalesAndMarketingMember_66848128-df55-451c-9578-97464ed20be9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_ResearchAndDevelopmentMember_79ba82d5-1614-4d3c-a00e-760f33cb5aee" xlink:href="app-20230331.xsd#app_ResearchAndDevelopmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_22bddd68-9e2e-41fa-b97c-b9bb734e7deb" xlink:to="loc_app_ResearchAndDevelopmentMember_79ba82d5-1614-4d3c-a00e-760f33cb5aee" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_GeneralAndAdministrativeMember_2920c2f0-bae4-4c4f-bc73-145e0535bf18" xlink:href="app-20230331.xsd#app_GeneralAndAdministrativeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_22bddd68-9e2e-41fa-b97c-b9bb734e7deb" xlink:to="loc_app_GeneralAndAdministrativeMember_2920c2f0-bae4-4c4f-bc73-145e0535bf18" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/StockbasedCompensationSummaryofShareBasedPaymentArrangementPerformanceSharesOutstandingActivityDetails" xlink:type="simple" xlink:href="app-20230331.xsd#StockbasedCompensationSummaryofShareBasedPaymentArrangementPerformanceSharesOutstandingActivityDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/StockbasedCompensationSummaryofShareBasedPaymentArrangementPerformanceSharesOutstandingActivityDetails" xlink:type="extended" id="i925043c25c6346cfaf9e0c127eb038a7_StockbasedCompensationSummaryofShareBasedPaymentArrangementPerformanceSharesOutstandingActivityDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_7f99f9e0-edbe-4249-88f3-854416ff1595" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_CommonStockPriceTargetValuePerShare_022b8638-7d2e-4e22-a2b1-c98436eeae1a" xlink:href="app-20230331.xsd#app_CommonStockPriceTargetValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_7f99f9e0-edbe-4249-88f3-854416ff1595" xlink:to="loc_app_CommonStockPriceTargetValuePerShare_022b8638-7d2e-4e22-a2b1-c98436eeae1a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestOutstandingNumber_6a741a35-8562-45e4-ace3-4ebebbbe50bf" xlink:href="app-20230331.xsd#app_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_7f99f9e0-edbe-4249-88f3-854416ff1595" xlink:to="loc_app_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestOutstandingNumber_6a741a35-8562-45e4-ace3-4ebebbbe50bf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_a2ef65e1-7611-4bed-8fdb-ad5a1d5cbbbf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_7f99f9e0-edbe-4249-88f3-854416ff1595" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_a2ef65e1-7611-4bed-8fdb-ad5a1d5cbbbf" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_CommonStockPriceTargetAxis_270014ff-d8f0-45c0-8538-10d9344c8932" xlink:href="app-20230331.xsd#app_CommonStockPriceTargetAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_a2ef65e1-7611-4bed-8fdb-ad5a1d5cbbbf" xlink:to="loc_app_CommonStockPriceTargetAxis_270014ff-d8f0-45c0-8538-10d9344c8932" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_CommonStockPriceTargetDomain_270014ff-d8f0-45c0-8538-10d9344c8932_default" xlink:href="app-20230331.xsd#app_CommonStockPriceTargetDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_app_CommonStockPriceTargetAxis_270014ff-d8f0-45c0-8538-10d9344c8932" xlink:to="loc_app_CommonStockPriceTargetDomain_270014ff-d8f0-45c0-8538-10d9344c8932_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_CommonStockPriceTargetDomain_dcb62c5b-c5d0-4ea6-af41-2fad2463f6d2" xlink:href="app-20230331.xsd#app_CommonStockPriceTargetDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_app_CommonStockPriceTargetAxis_270014ff-d8f0-45c0-8538-10d9344c8932" xlink:to="loc_app_CommonStockPriceTargetDomain_dcb62c5b-c5d0-4ea6-af41-2fad2463f6d2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_CommonStockPriceTargetOneMember_42c76980-55e9-4fff-a011-68b4297416a3" xlink:href="app-20230331.xsd#app_CommonStockPriceTargetOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_app_CommonStockPriceTargetDomain_dcb62c5b-c5d0-4ea6-af41-2fad2463f6d2" xlink:to="loc_app_CommonStockPriceTargetOneMember_42c76980-55e9-4fff-a011-68b4297416a3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_CommonStockPriceTargetTwoMember_3db4cd42-12a4-4a6c-a880-f52678a06862" xlink:href="app-20230331.xsd#app_CommonStockPriceTargetTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_app_CommonStockPriceTargetDomain_dcb62c5b-c5d0-4ea6-af41-2fad2463f6d2" xlink:to="loc_app_CommonStockPriceTargetTwoMember_3db4cd42-12a4-4a6c-a880-f52678a06862" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_CommonStockPriceTargetThreeMember_5083a3ce-8641-44ff-bc3a-dd3a0eb0ff96" xlink:href="app-20230331.xsd#app_CommonStockPriceTargetThreeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_app_CommonStockPriceTargetDomain_dcb62c5b-c5d0-4ea6-af41-2fad2463f6d2" xlink:to="loc_app_CommonStockPriceTargetThreeMember_5083a3ce-8641-44ff-bc3a-dd3a0eb0ff96" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_CommonStockPriceTargetFourMember_2fea1a32-d473-4cfc-8530-88375a484f55" xlink:href="app-20230331.xsd#app_CommonStockPriceTargetFourMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_app_CommonStockPriceTargetDomain_dcb62c5b-c5d0-4ea6-af41-2fad2463f6d2" xlink:to="loc_app_CommonStockPriceTargetFourMember_2fea1a32-d473-4cfc-8530-88375a484f55" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_CommonStockPriceTargetFiveMember_f7f77492-2164-4312-b692-04c612362651" xlink:href="app-20230331.xsd#app_CommonStockPriceTargetFiveMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_app_CommonStockPriceTargetDomain_dcb62c5b-c5d0-4ea6-af41-2fad2463f6d2" xlink:to="loc_app_CommonStockPriceTargetFiveMember_f7f77492-2164-4312-b692-04c612362651" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_6979b171-4613-45ce-9bb2-4497c44e2368" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_a2ef65e1-7611-4bed-8fdb-ad5a1d5cbbbf" xlink:to="loc_us-gaap_PlanNameAxis_6979b171-4613-45ce-9bb2-4497c44e2368" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_6979b171-4613-45ce-9bb2-4497c44e2368_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_6979b171-4613-45ce-9bb2-4497c44e2368" xlink:to="loc_us-gaap_PlanNameDomain_6979b171-4613-45ce-9bb2-4497c44e2368_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_bebf2d7b-bdf9-4ef1-8757-42ea557415d9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_6979b171-4613-45ce-9bb2-4497c44e2368" xlink:to="loc_us-gaap_PlanNameDomain_bebf2d7b-bdf9-4ef1-8757-42ea557415d9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_PSUGrantsMember_e4a0159c-e9e8-4e0d-bb70-1bcef8576798" xlink:href="app-20230331.xsd#app_PSUGrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_bebf2d7b-bdf9-4ef1-8757-42ea557415d9" xlink:to="loc_app_PSUGrantsMember_e4a0159c-e9e8-4e0d-bb70-1bcef8576798" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_f106e741-9c08-40d7-a31a-1313bc6fb94d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_a2ef65e1-7611-4bed-8fdb-ad5a1d5cbbbf" xlink:to="loc_us-gaap_AwardTypeAxis_f106e741-9c08-40d7-a31a-1313bc6fb94d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_f106e741-9c08-40d7-a31a-1313bc6fb94d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_f106e741-9c08-40d7-a31a-1313bc6fb94d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_f106e741-9c08-40d7-a31a-1313bc6fb94d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_6cb54e85-0cea-400d-b263-2c5ad7c672c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_f106e741-9c08-40d7-a31a-1313bc6fb94d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_6cb54e85-0cea-400d-b263-2c5ad7c672c1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_d63ff0db-6a2e-4bd9-8616-24a6c7a17046" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PerformanceSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_6cb54e85-0cea-400d-b263-2c5ad7c672c1" xlink:to="loc_us-gaap_PerformanceSharesMember_d63ff0db-6a2e-4bd9-8616-24a6c7a17046" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionAxis_9d99c296-f4eb-4c40-b15c-8517d3e60423" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_a2ef65e1-7611-4bed-8fdb-ad5a1d5cbbbf" xlink:to="loc_us-gaap_RelatedPartyTransactionAxis_9d99c296-f4eb-4c40-b15c-8517d3e60423" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_9d99c296-f4eb-4c40-b15c-8517d3e60423_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_9d99c296-f4eb-4c40-b15c-8517d3e60423" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_9d99c296-f4eb-4c40-b15c-8517d3e60423_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_c6fc4ded-09ed-49e8-8237-7c8b49d620d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_9d99c296-f4eb-4c40-b15c-8517d3e60423" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_c6fc4ded-09ed-49e8-8237-7c8b49d620d5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_AdamForoughiMember_ce9ffc1b-9be3-45b7-9daa-33ba27140113" xlink:href="app-20230331.xsd#app_AdamForoughiMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_c6fc4ded-09ed-49e8-8237-7c8b49d620d5" xlink:to="loc_app_AdamForoughiMember_ce9ffc1b-9be3-45b7-9daa-33ba27140113" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_VasilyShikinMember_0c472743-dbaf-47e4-b915-c1a36ccba43f" xlink:href="app-20230331.xsd#app_VasilyShikinMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_c6fc4ded-09ed-49e8-8237-7c8b49d620d5" xlink:to="loc_app_VasilyShikinMember_0c472743-dbaf-47e4-b915-c1a36ccba43f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualAxis_6f9df178-827e-4682-be67-4d45bd4381f0" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_a2ef65e1-7611-4bed-8fdb-ad5a1d5cbbbf" xlink:to="loc_srt_TitleOfIndividualAxis_6f9df178-827e-4682-be67-4d45bd4381f0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_6f9df178-827e-4682-be67-4d45bd4381f0_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_TitleOfIndividualAxis_6f9df178-827e-4682-be67-4d45bd4381f0" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_6f9df178-827e-4682-be67-4d45bd4381f0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_36313bf1-e52f-480f-8782-86963385fcc7" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_TitleOfIndividualAxis_6f9df178-827e-4682-be67-4d45bd4381f0" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_36313bf1-e52f-480f-8782-86963385fcc7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ChiefExecutiveOfficerMember_3bd98466-7d0c-499a-ad34-f3218834613d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ChiefExecutiveOfficerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_36313bf1-e52f-480f-8782-86963385fcc7" xlink:to="loc_srt_ChiefExecutiveOfficerMember_3bd98466-7d0c-499a-ad34-f3218834613d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_ChiefTreasuryOfficersMember_e988c950-e68f-406a-9cfc-eb46bf1c608a" xlink:href="app-20230331.xsd#app_ChiefTreasuryOfficersMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_36313bf1-e52f-480f-8782-86963385fcc7" xlink:to="loc_app_ChiefTreasuryOfficersMember_e988c950-e68f-406a-9cfc-eb46bf1c608a" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/EarningsPerShareSummaryofAntidilutivePotentialCommonSharesDetails" xlink:type="simple" xlink:href="app-20230331.xsd#EarningsPerShareSummaryofAntidilutivePotentialCommonSharesDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/EarningsPerShareSummaryofAntidilutivePotentialCommonSharesDetails" xlink:type="extended" id="ia19b352d0b6e4178b213395695afe9fe_EarningsPerShareSummaryofAntidilutivePotentialCommonSharesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_a6a7fb60-be22-4f13-8e1d-0667cc882494" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_919911e9-5dae-4efc-8199-eb649596d56c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_a6a7fb60-be22-4f13-8e1d-0667cc882494" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_919911e9-5dae-4efc-8199-eb649596d56c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_c5b08e94-4ff0-4d48-b0e5-c255948f0a48" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_a6a7fb60-be22-4f13-8e1d-0667cc882494" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_c5b08e94-4ff0-4d48-b0e5-c255948f0a48" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_5df802c3-5044-4f90-829b-d5354f1dbc7a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_c5b08e94-4ff0-4d48-b0e5-c255948f0a48" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_5df802c3-5044-4f90-829b-d5354f1dbc7a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_5df802c3-5044-4f90-829b-d5354f1dbc7a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_5df802c3-5044-4f90-829b-d5354f1dbc7a" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_5df802c3-5044-4f90-829b-d5354f1dbc7a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_20769020-e737-449e-838a-b4581cbfbc15" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_5df802c3-5044-4f90-829b-d5354f1dbc7a" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_20769020-e737-449e-838a-b4581cbfbc15" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_OptionsExercisedForPromissoryNotesMember_bd547b96-336e-4b64-9de0-639cf3fdd571" xlink:href="app-20230331.xsd#app_OptionsExercisedForPromissoryNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_20769020-e737-449e-838a-b4581cbfbc15" xlink:to="loc_app_OptionsExercisedForPromissoryNotesMember_bd547b96-336e-4b64-9de0-639cf3fdd571" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_EarlyExercisedOptionsMember_ce8ae8eb-bf91-4562-b6b5-13f8eb68c0b1" xlink:href="app-20230331.xsd#app_EarlyExercisedOptionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_20769020-e737-449e-838a-b4581cbfbc15" xlink:to="loc_app_EarlyExercisedOptionsMember_ce8ae8eb-bf91-4562-b6b5-13f8eb68c0b1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_UnvestedRsasMember_1822efd9-1c0b-48e3-9ca3-418e29b90c40" xlink:href="app-20230331.xsd#app_UnvestedRsasMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_20769020-e737-449e-838a-b4581cbfbc15" xlink:to="loc_app_UnvestedRsasMember_1822efd9-1c0b-48e3-9ca3-418e29b90c40" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_11f9c0ec-d80d-4236-97ea-e602dec6f03d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_20769020-e737-449e-838a-b4581cbfbc15" xlink:to="loc_us-gaap_EmployeeStockOptionMember_11f9c0ec-d80d-4236-97ea-e602dec6f03d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_1889d481-c66b-4af9-a13b-50fdffddee12" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_20769020-e737-449e-838a-b4581cbfbc15" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_1889d481-c66b-4af9-a13b-50fdffddee12" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_b728768f-12f9-4566-a027-58f3dff30a6c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_20769020-e737-449e-838a-b4581cbfbc15" xlink:to="loc_us-gaap_EmployeeStockMember_b728768f-12f9-4566-a027-58f3dff30a6c" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/SegmentsScheduleofSegmentReportingInformationDetails" xlink:type="simple" xlink:href="app-20230331.xsd#SegmentsScheduleofSegmentReportingInformationDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/SegmentsScheduleofSegmentReportingInformationDetails" xlink:type="extended" id="i03b05dde109f4216837c4938954da73c_SegmentsScheduleofSegmentReportingInformationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingReconcilingItemForOperatingProfitLossFromSegmentToConsolidatedLineItems_65725991-e423-4580-abc4-afe2aa1aa6fa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentReportingReconcilingItemForOperatingProfitLossFromSegmentToConsolidatedLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_aabd56fc-6b07-4703-8079-7068a18abea1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingReconcilingItemForOperatingProfitLossFromSegmentToConsolidatedLineItems_65725991-e423-4580-abc4-afe2aa1aa6fa" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_aabd56fc-6b07-4703-8079-7068a18abea1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_AdjustedEarningsBeforeInterestTaxesDepreciationAndAmortization_163e810c-3376-4314-b7c5-b18139599f46" xlink:href="app-20230331.xsd#app_AdjustedEarningsBeforeInterestTaxesDepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingReconcilingItemForOperatingProfitLossFromSegmentToConsolidatedLineItems_65725991-e423-4580-abc4-afe2aa1aa6fa" xlink:to="loc_app_AdjustedEarningsBeforeInterestTaxesDepreciationAndAmortization_163e810c-3376-4314-b7c5-b18139599f46" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDebtExpense_88f1ec6b-9814-4f95-aa0a-e9642ffb5377" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestAndDebtExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingReconcilingItemForOperatingProfitLossFromSegmentToConsolidatedLineItems_65725991-e423-4580-abc4-afe2aa1aa6fa" xlink:to="loc_us-gaap_InterestAndDebtExpense_88f1ec6b-9814-4f95-aa0a-e9642ffb5377" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_c979fbc7-a998-4f7d-a5aa-1712a57b244b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingReconcilingItemForOperatingProfitLossFromSegmentToConsolidatedLineItems_65725991-e423-4580-abc4-afe2aa1aa6fa" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_c979fbc7-a998-4f7d-a5aa-1712a57b244b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_4a8000f3-8343-438d-91f1-26f067bf733d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingReconcilingItemForOperatingProfitLossFromSegmentToConsolidatedLineItems_65725991-e423-4580-abc4-afe2aa1aa6fa" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_4a8000f3-8343-438d-91f1-26f067bf733d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_af22b6b5-60a4-44c7-b666-c12f79633020" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingReconcilingItemForOperatingProfitLossFromSegmentToConsolidatedLineItems_65725991-e423-4580-abc4-afe2aa1aa6fa" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_af22b6b5-60a4-44c7-b666-c12f79633020" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_987a6f69-4127-4ec2-98f1-373cef985073" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingReconcilingItemForOperatingProfitLossFromSegmentToConsolidatedLineItems_65725991-e423-4580-abc4-afe2aa1aa6fa" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_987a6f69-4127-4ec2-98f1-373cef985073" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_a9a68873-f9d5-452b-85c5-f14721c40f8e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingReconcilingItemForOperatingProfitLossFromSegmentToConsolidatedLineItems_65725991-e423-4580-abc4-afe2aa1aa6fa" xlink:to="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_a9a68873-f9d5-452b-85c5-f14721c40f8e" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_ConsiderationIncurredForExistingAndPotentialCustomerIncentiveBonuses_d06c693c-87d0-4b00-8c7f-846fb21d7553" xlink:href="app-20230331.xsd#app_ConsiderationIncurredForExistingAndPotentialCustomerIncentiveBonuses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingReconcilingItemForOperatingProfitLossFromSegmentToConsolidatedLineItems_65725991-e423-4580-abc4-afe2aa1aa6fa" xlink:to="loc_app_ConsiderationIncurredForExistingAndPotentialCustomerIncentiveBonuses_d06c693c-87d0-4b00-8c7f-846fb21d7553" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_BusinessAcquisitionAcquisitionTransitionServices_d80c3747-3c7c-430c-b027-b9db12416d73" xlink:href="app-20230331.xsd#app_BusinessAcquisitionAcquisitionTransitionServices"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingReconcilingItemForOperatingProfitLossFromSegmentToConsolidatedLineItems_65725991-e423-4580-abc4-afe2aa1aa6fa" xlink:to="loc_app_BusinessAcquisitionAcquisitionTransitionServices_d80c3747-3c7c-430c-b027-b9db12416d73" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCosts_d7d0f847-c19b-48ff-a378-586d2a21a3ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingReconcilingItemForOperatingProfitLossFromSegmentToConsolidatedLineItems_65725991-e423-4580-abc4-afe2aa1aa6fa" xlink:to="loc_us-gaap_RestructuringCosts_d7d0f847-c19b-48ff-a378-586d2a21a3ed" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e18455d7-9715-4318-b943-50cbd7997686" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingReconcilingItemForOperatingProfitLossFromSegmentToConsolidatedLineItems_65725991-e423-4580-abc4-afe2aa1aa6fa" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e18455d7-9715-4318-b943-50cbd7997686" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReconciliationOfOperatingProfitLossFromSegmentsToConsolidatedTable_b01f5f65-4a4a-4a59-8852-d25bab64e9fe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReconciliationOfOperatingProfitLossFromSegmentsToConsolidatedTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingReconcilingItemForOperatingProfitLossFromSegmentToConsolidatedLineItems_65725991-e423-4580-abc4-afe2aa1aa6fa" xlink:to="loc_us-gaap_ReconciliationOfOperatingProfitLossFromSegmentsToConsolidatedTable_b01f5f65-4a4a-4a59-8852-d25bab64e9fe" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_f3456c0c-ec17-48c9-a3d7-fdfe06a749d0" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReconciliationOfOperatingProfitLossFromSegmentsToConsolidatedTable_b01f5f65-4a4a-4a59-8852-d25bab64e9fe" xlink:to="loc_srt_ConsolidationItemsAxis_f3456c0c-ec17-48c9-a3d7-fdfe06a749d0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_f3456c0c-ec17-48c9-a3d7-fdfe06a749d0_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_f3456c0c-ec17-48c9-a3d7-fdfe06a749d0" xlink:to="loc_srt_ConsolidationItemsDomain_f3456c0c-ec17-48c9-a3d7-fdfe06a749d0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_0f488d69-ff16-4c79-b175-0195de345aba" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_f3456c0c-ec17-48c9-a3d7-fdfe06a749d0" xlink:to="loc_srt_ConsolidationItemsDomain_0f488d69-ff16-4c79-b175-0195de345aba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaterialReconcilingItemsMember_77c27a9a-f9e9-4274-9e73-97ac2f568fc0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MaterialReconcilingItemsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_0f488d69-ff16-4c79-b175-0195de345aba" xlink:to="loc_us-gaap_MaterialReconcilingItemsMember_77c27a9a-f9e9-4274-9e73-97ac2f568fc0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_b64b8e75-b3f4-46c9-bda9-8200786c8a3a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReconciliationOfOperatingProfitLossFromSegmentsToConsolidatedTable_b01f5f65-4a4a-4a59-8852-d25bab64e9fe" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_b64b8e75-b3f4-46c9-bda9-8200786c8a3a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_b64b8e75-b3f4-46c9-bda9-8200786c8a3a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_b64b8e75-b3f4-46c9-bda9-8200786c8a3a" xlink:to="loc_us-gaap_SegmentDomain_b64b8e75-b3f4-46c9-bda9-8200786c8a3a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_82503ea1-6a2f-4c0c-a31e-845abcb33d51" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_b64b8e75-b3f4-46c9-bda9-8200786c8a3a" xlink:to="loc_us-gaap_SegmentDomain_82503ea1-6a2f-4c0c-a31e-845abcb33d51" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_SoftwarePlatformMember_28da15c5-400a-4f85-b04e-1033eb12e5a8" xlink:href="app-20230331.xsd#app_SoftwarePlatformMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_82503ea1-6a2f-4c0c-a31e-845abcb33d51" xlink:to="loc_app_SoftwarePlatformMember_28da15c5-400a-4f85-b04e-1033eb12e5a8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_AppsMember_0e104014-812a-4b9f-bac3-27c2b77140a9" xlink:href="app-20230331.xsd#app_AppsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_82503ea1-6a2f-4c0c-a31e-845abcb33d51" xlink:to="loc_app_AppsMember_0e104014-812a-4b9f-bac3-27c2b77140a9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_e12178ac-cf73-4b17-86f0-aac4c2552026" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReconciliationOfOperatingProfitLossFromSegmentsToConsolidatedTable_b01f5f65-4a4a-4a59-8852-d25bab64e9fe" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_e12178ac-cf73-4b17-86f0-aac4c2552026" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_e12178ac-cf73-4b17-86f0-aac4c2552026_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_e12178ac-cf73-4b17-86f0-aac4c2552026" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_e12178ac-cf73-4b17-86f0-aac4c2552026_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3dc3d2e6-d9f7-4ca8-9c08-372cce51df4b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_e12178ac-cf73-4b17-86f0-aac4c2552026" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3dc3d2e6-d9f7-4ca8-9c08-372cce51df4b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_MoPubMember_abbf1de5-0ad6-45b0-bb69-ab5239f217b5" xlink:href="app-20230331.xsd#app_MoPubMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3dc3d2e6-d9f7-4ca8-9c08-372cce51df4b" xlink:to="loc_app_MoPubMember_abbf1de5-0ad6-45b0-bb69-ab5239f217b5" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.applovin.com/role/SubsequentEventsNarrativeDetails" xlink:type="simple" xlink:href="app-20230331.xsd#SubsequentEventsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.applovin.com/role/SubsequentEventsNarrativeDetails" xlink:type="extended" id="i03cbf7c609904b52be0fc37784991fea_SubsequentEventsNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_26298bd1-c0d1-44d0-b013-6e45f29d6662" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_e26d9753-12f2-4cec-b98f-08db93a31f7c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_26298bd1-c0d1-44d0-b013-6e45f29d6662" xlink:to="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_e26d9753-12f2-4cec-b98f-08db93a31f7c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_2084c490-521f-483c-a9d2-c7630d527357" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_26298bd1-c0d1-44d0-b013-6e45f29d6662" xlink:to="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_2084c490-521f-483c-a9d2-c7630d527357" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_1b681ede-a7fd-4c33-99e7-d8687bea8b16" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_26298bd1-c0d1-44d0-b013-6e45f29d6662" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_1b681ede-a7fd-4c33-99e7-d8687bea8b16" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_7e2b971b-6442-4942-b60c-3a9dd27eca4a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_26298bd1-c0d1-44d0-b013-6e45f29d6662" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_7e2b971b-6442-4942-b60c-3a9dd27eca4a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_27d9ede0-1294-4de8-b92e-83f28afdbc04" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_26298bd1-c0d1-44d0-b013-6e45f29d6662" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_27d9ede0-1294-4de8-b92e-83f28afdbc04" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_6b33c596-ec96-47fe-ba1a-1e81e5c22c0f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_26298bd1-c0d1-44d0-b013-6e45f29d6662" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_6b33c596-ec96-47fe-ba1a-1e81e5c22c0f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_app_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsMaximumAchievementPayout_bdda85e5-859a-4a4f-bfb9-cc0f4eaf7724" xlink:href="app-20230331.xsd#app_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsMaximumAchievementPayout"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_26298bd1-c0d1-44d0-b013-6e45f29d6662" xlink:to="loc_app_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsMaximumAchievementPayout_bdda85e5-859a-4a4f-bfb9-cc0f4eaf7724" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_1032e8a9-1169-402a-92f6-873af2b28837" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsequentEventLineItems_26298bd1-c0d1-44d0-b013-6e45f29d6662" xlink:to="loc_us-gaap_SubsequentEventTable_1032e8a9-1169-402a-92f6-873af2b28837" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_1e729262-07e8-4d65-bd02-d1328725c6e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_1032e8a9-1169-402a-92f6-873af2b28837" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_1e729262-07e8-4d65-bd02-d1328725c6e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_1e729262-07e8-4d65-bd02-d1328725c6e2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_1e729262-07e8-4d65-bd02-d1328725c6e2" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_1e729262-07e8-4d65-bd02-d1328725c6e2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_2a1ee61a-54fe-4840-bb1f-c999ccc4d476" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_1e729262-07e8-4d65-bd02-d1328725c6e2" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_2a1ee61a-54fe-4840-bb1f-c999ccc4d476" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_8f70c6a2-31d1-4944-8766-1185d3e87954" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_2a1ee61a-54fe-4840-bb1f-c999ccc4d476" xlink:to="loc_us-gaap_SubsequentEventMember_8f70c6a2-31d1-4944-8766-1185d3e87954" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_06be96b0-b0f7-47ae-a38a-f5bc5cf8a8ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_1032e8a9-1169-402a-92f6-873af2b28837" xlink:to="loc_us-gaap_StatementClassOfStockAxis_06be96b0-b0f7-47ae-a38a-f5bc5cf8a8ad" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_06be96b0-b0f7-47ae-a38a-f5bc5cf8a8ad_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_06be96b0-b0f7-47ae-a38a-f5bc5cf8a8ad" xlink:to="loc_us-gaap_ClassOfStockDomain_06be96b0-b0f7-47ae-a38a-f5bc5cf8a8ad_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_2c098dd9-9a99-4d55-9609-331e6cd513ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_06be96b0-b0f7-47ae-a38a-f5bc5cf8a8ad" xlink:to="loc_us-gaap_ClassOfStockDomain_2c098dd9-9a99-4d55-9609-331e6cd513ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_5dea98d1-163b-4162-8264-b664ad109636" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_2c098dd9-9a99-4d55-9609-331e6cd513ee" xlink:to="loc_us-gaap_CommonClassAMember_5dea98d1-163b-4162-8264-b664ad109636" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_3c8cd3d5-0243-4988-8747-78b558adae2d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_1032e8a9-1169-402a-92f6-873af2b28837" xlink:to="loc_us-gaap_AwardTypeAxis_3c8cd3d5-0243-4988-8747-78b558adae2d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3c8cd3d5-0243-4988-8747-78b558adae2d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_3c8cd3d5-0243-4988-8747-78b558adae2d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3c8cd3d5-0243-4988-8747-78b558adae2d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a6f1ad3a-2c19-4995-b593-22473c372b97" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_3c8cd3d5-0243-4988-8747-78b558adae2d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a6f1ad3a-2c19-4995-b593-22473c372b97" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_3289b001-5dd4-49d8-b412-c4b8979dc20b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PerformanceSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a6f1ad3a-2c19-4995-b593-22473c372b97" xlink:to="loc_us-gaap_PerformanceSharesMember_3289b001-5dd4-49d8-b412-c4b8979dc20b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_805e926a-b748-4b60-85b2-f668987d5994" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_1032e8a9-1169-402a-92f6-873af2b28837" xlink:to="loc_srt_StatementScenarioAxis_805e926a-b748-4b60-85b2-f668987d5994" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_805e926a-b748-4b60-85b2-f668987d5994_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_805e926a-b748-4b60-85b2-f668987d5994" xlink:to="loc_srt_ScenarioUnspecifiedDomain_805e926a-b748-4b60-85b2-f668987d5994_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_5476781e-8081-4e55-a758-c34b810edef8" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_805e926a-b748-4b60-85b2-f668987d5994" xlink:to="loc_srt_ScenarioUnspecifiedDomain_5476781e-8081-4e55-a758-c34b810edef8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioForecastMember_faa79197-a5ab-4dff-9542-fba0a7a04990" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioForecastMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ScenarioUnspecifiedDomain_5476781e-8081-4e55-a758-c34b810edef8" xlink:to="loc_srt_ScenarioForecastMember_faa79197-a5ab-4dff-9542-fba0a7a04990" xlink:type="arc" order="0"/>
  </link:definitionLink>
</link:linkbase>
