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Goodwill and Intangible Assets - Intangible Assets (Details) - USD ($) $ in Millions | 6 Months Ended |
--- | --- | ---
Jun. 30, 2016 | Dec. 31, 2015
Goodwill and Intangible Assets |  |
Gross amount of amortizable intangible assets | $ 10,900 | $ 10,800
Accumulated amortization of intangible assets | 6,000 | 5,700
Change in intangible assets due to foreign currency translation and other adjustments | 54 |
Indefinite-lived intangible assets related to in-process research and development acquired in a business combination | 390 | $ 419
Estimated annual amortization expense, intangible assets, 2016 | 580 |
Estimated annual amortization expense, intangible assets, 2017 | 560 |
Estimated annual amortization expense, intangible assets, 2018 | 520 |
Estimated annual amortization expense, intangible assets, 2019 | 490 |
Estimated annual amortization expense, intangible assets, 2020 | 480 |
Non-reportable segment |  |
Goodwill and Intangible Assets |  |
Impairment charges for certain research and development assets | $ 43 |
Minimum |  |
Goodwill and Intangible Assets |  |
Average amortization period, intangible assets | 2 years |
Maximum |  |
Goodwill and Intangible Assets |  |
Average amortization period, intangible assets | 20 years |
Average |  |
Goodwill and Intangible Assets |  |
Average amortization period, intangible assets | 14 years |

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