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Goodwill and Intangible Assets - Intangible Assets (Details) - USD ($) $ in Millions | 6 Months Ended |
--- | --- | ---
Jun. 30, 2021 | Dec. 31, 2020
Goodwill and Intangible Assets |  |
Gross amount of amortizable intangible assets | $ 27,800 | $ 27,800
Accumulated amortization of intangible assets | 15,100 | 14,200
Increase (Decrease) in intangible assets due to foreign currency translation adjustments | (83) |
Estimated annual amortization expense, intangible assets, 2021 | 2,000 |
Estimated annual amortization expense, intangible assets, 2022 | 2,000 |
Estimated annual amortization expense, intangible assets, 2023 | 1,900 |
Estimated annual amortization expense, intangible assets, 2024 | 1,900 |
Estimated annual amortization expense, intangible assets, 2025 | 1,900 |
Indefinite-lived intangible assets related to in-process R&D acquired in a business combination | 947 | $ 1,200
Established Pharmaceutical Products Segment |  |
Goodwill and Intangible Assets |  |
Impairment of amortizable intangible assets | $ 11 |

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