<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2020 Workiva-->
<!--r:9eef1f3f-5ed3-48aa-89e9-39be7f0583f1,g:367dd906-db06-488f-9a0a-2ec32e9a0c61-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/CoverPage" xlink:type="simple" xlink:href="isrg-20200630.xsd#CoverPage"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/CoverPage" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="simple" xlink:href="isrg-20200630.xsd#CondensedConsolidatedBalanceSheetsUnaudited"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_c17438ea-5ba4-488d-baab-7ab3ab85c831" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_a08a0431-c950-4c29-9d87-0bdd21ccd5c2" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c17438ea-5ba4-488d-baab-7ab3ab85c831" xlink:to="loc_us-gaap_AccountsPayableCurrent_a08a0431-c950-4c29-9d87-0bdd21ccd5c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_11ef2168-33dd-425c-bafe-9a4a1b1889fb" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c17438ea-5ba4-488d-baab-7ab3ab85c831" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_11ef2168-33dd-425c-bafe-9a4a1b1889fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueCurrent_bc35359f-7ddb-4183-848e-593549be79bc" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredRevenueCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c17438ea-5ba4-488d-baab-7ab3ab85c831" xlink:to="loc_us-gaap_DeferredRevenueCurrent_bc35359f-7ddb-4183-848e-593549be79bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_2ee4adb7-439c-4e27-99a6-f1985693da60" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c17438ea-5ba4-488d-baab-7ab3ab85c831" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_2ee4adb7-439c-4e27-99a6-f1985693da60" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_c2700a8c-304c-4913-9a44-0bae9d49d4f6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_61aeb4a4-b6f7-4677-b5d4-0c4deb5e6bd7" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c2700a8c-304c-4913-9a44-0bae9d49d4f6" xlink:to="loc_us-gaap_PreferredStockValue_61aeb4a4-b6f7-4677-b5d4-0c4deb5e6bd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_0c496df1-db8a-4157-849f-b8012478732f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c2700a8c-304c-4913-9a44-0bae9d49d4f6" xlink:to="loc_us-gaap_CommonStockValue_0c496df1-db8a-4157-849f-b8012478732f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_5b91a16e-8ee0-413d-929e-0362806cb2b5" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c2700a8c-304c-4913-9a44-0bae9d49d4f6" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_5b91a16e-8ee0-413d-929e-0362806cb2b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_4b6c1fc4-ecca-4577-b265-3c27b1e28290" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c2700a8c-304c-4913-9a44-0bae9d49d4f6" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_4b6c1fc4-ecca-4577-b265-3c27b1e28290" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_d2e3a439-cc80-4f8a-bee7-eab9d18a015f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c2700a8c-304c-4913-9a44-0bae9d49d4f6" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_d2e3a439-cc80-4f8a-bee7-eab9d18a015f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_1a940e61-2c98-4e75-8958-a90b27f40127" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_73f3c5f6-47a9-478b-913a-5575bba0fbed" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_1a940e61-2c98-4e75-8958-a90b27f40127" xlink:to="loc_us-gaap_LiabilitiesCurrent_73f3c5f6-47a9-478b-913a-5575bba0fbed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_75997ff6-d329-46d3-b0ed-1dc9cfee195b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_1a940e61-2c98-4e75-8958-a90b27f40127" xlink:to="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_75997ff6-d329-46d3-b0ed-1dc9cfee195b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_c0d55e04-591b-4d9d-99f2-247064332ef4" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_c25e919e-b2bf-44cf-8f2e-86f3b80672e2" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_c0d55e04-591b-4d9d-99f2-247064332ef4" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_c25e919e-b2bf-44cf-8f2e-86f3b80672e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_b836af60-57e1-4215-bae6-ecdf801122c6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_c0d55e04-591b-4d9d-99f2-247064332ef4" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_b836af60-57e1-4215-bae6-ecdf801122c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_84798dcb-75d6-45d8-9b1f-f380666c4546" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_c0d55e04-591b-4d9d-99f2-247064332ef4" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_84798dcb-75d6-45d8-9b1f-f380666c4546" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_5c2197e9-f1a6-4f45-8cc5-af30471fa658" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_c0d55e04-591b-4d9d-99f2-247064332ef4" xlink:to="loc_us-gaap_InventoryNet_5c2197e9-f1a6-4f45-8cc5-af30471fa658" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_3a1d9c57-691f-4c2e-8d7c-94a5a92ea2b7" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_c0d55e04-591b-4d9d-99f2-247064332ef4" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_3a1d9c57-691f-4c2e-8d7c-94a5a92ea2b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_d3b1c2e5-d8bf-400d-af82-2a21c5e7eb6c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_efbcb909-6556-433a-9cc1-520ec9cb4d1c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d3b1c2e5-d8bf-400d-af82-2a21c5e7eb6c" xlink:to="loc_us-gaap_AssetsCurrent_efbcb909-6556-433a-9cc1-520ec9cb4d1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_8464af7d-42b1-4e69-a3ca-1405482de943" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d3b1c2e5-d8bf-400d-af82-2a21c5e7eb6c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_8464af7d-42b1-4e69-a3ca-1405482de943" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesNoncurrent_c7ae0c69-8847-41af-873c-2a89dde81fa7" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MarketableSecuritiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d3b1c2e5-d8bf-400d-af82-2a21c5e7eb6c" xlink:to="loc_us-gaap_MarketableSecuritiesNoncurrent_c7ae0c69-8847-41af-873c-2a89dde81fa7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_1bd8cb3f-bb65-4669-855e-c167f32fae0f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d3b1c2e5-d8bf-400d-af82-2a21c5e7eb6c" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_1bd8cb3f-bb65-4669-855e-c167f32fae0f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_IntangibleAndOtherAssets_bc1b5104-bd9e-4455-95b7-092b6935aa07" xlink:href="isrg-20200630.xsd#isrg_IntangibleAndOtherAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d3b1c2e5-d8bf-400d-af82-2a21c5e7eb6c" xlink:to="loc_isrg_IntangibleAndOtherAssets_bc1b5104-bd9e-4455-95b7-092b6935aa07" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_b5758b0e-c2f3-41c0-97d1-50f76da4de18" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_d3b1c2e5-d8bf-400d-af82-2a21c5e7eb6c" xlink:to="loc_us-gaap_Goodwill_b5758b0e-c2f3-41c0-97d1-50f76da4de18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_27ed5808-1493-4eec-a87f-06017fa28e50" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_df4752b8-20e2-4d03-a5e0-96f627b47e31" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_27ed5808-1493-4eec-a87f-06017fa28e50" xlink:to="loc_us-gaap_Liabilities_df4752b8-20e2-4d03-a5e0-96f627b47e31" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_69259f20-ff5e-4027-bdf1-cc8601f37272" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_27ed5808-1493-4eec-a87f-06017fa28e50" xlink:to="loc_us-gaap_CommitmentsAndContingencies_69259f20-ff5e-4027-bdf1-cc8601f37272" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_2969edfb-f0f1-4bb6-b273-01f48a7f78d8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_27ed5808-1493-4eec-a87f-06017fa28e50" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_2969edfb-f0f1-4bb6-b273-01f48a7f78d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d1dea608-ab0d-48ef-95f0-d48e80a3c33f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_c0645c61-2e49-4954-b863-19164bab436b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d1dea608-ab0d-48ef-95f0-d48e80a3c33f" xlink:to="loc_us-gaap_StockholdersEquity_c0645c61-2e49-4954-b863-19164bab436b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterest_9c4d0eb7-814c-4554-8dcf-d42d64a6bd9d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_MinorityInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d1dea608-ab0d-48ef-95f0-d48e80a3c33f" xlink:to="loc_us-gaap_MinorityInterest_9c4d0eb7-814c-4554-8dcf-d42d64a6bd9d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="isrg-20200630.xsd#CondensedConsolidatedBalanceSheetsParenthetical"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/CondensedConsolidatedStatementsofComprehensiveIncomeUnaudited" xlink:type="simple" xlink:href="isrg-20200630.xsd#CondensedConsolidatedStatementsofComprehensiveIncomeUnaudited"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/CondensedConsolidatedStatementsofComprehensiveIncomeUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_53c4e33d-1bf0-4f26-bffc-6a7dd8424c87" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_d1d1f9b8-5464-4721-ae4d-912738a894c8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_53c4e33d-1bf0-4f26-bffc-6a7dd8424c87" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_d1d1f9b8-5464-4721-ae4d-912738a894c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_1cadd320-8e7a-4552-9f0c-700277b1d456" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_53c4e33d-1bf0-4f26-bffc-6a7dd8424c87" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_1cadd320-8e7a-4552-9f0c-700277b1d456" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_710cb004-e0e5-4e24-8311-3564f3fe1366" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_9229f68b-a80e-4b78-8ab5-12473f039885" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_710cb004-e0e5-4e24-8311-3564f3fe1366" xlink:to="loc_us-gaap_GrossProfit_9229f68b-a80e-4b78-8ab5-12473f039885" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_01770db0-31ca-4a30-8308-3293dd38e527" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_710cb004-e0e5-4e24-8311-3564f3fe1366" xlink:to="loc_us-gaap_OperatingExpenses_01770db0-31ca-4a30-8308-3293dd38e527" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_8e27b10f-9bbe-41b4-a64e-098a8850c2d3" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_ca960a3a-8182-46a9-a2ac-80d4c7a25fcb" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_8e27b10f-9bbe-41b4-a64e-098a8850c2d3" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_ca960a3a-8182-46a9-a2ac-80d4c7a25fcb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_ce300c74-79aa-40c4-85da-9867d9405d50" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_8e27b10f-9bbe-41b4-a64e-098a8850c2d3" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_ce300c74-79aa-40c4-85da-9867d9405d50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_32e7ec1b-ae98-4ffd-8cc4-1f55faf4d4e9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_c1fcf939-b677-4e52-9ddf-c06e6ab297aa" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_32e7ec1b-ae98-4ffd-8cc4-1f55faf4d4e9" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_c1fcf939-b677-4e52-9ddf-c06e6ab297aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_91562d72-dfa3-4468-9799-3a2887c5eec8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_32e7ec1b-ae98-4ffd-8cc4-1f55faf4d4e9" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_91562d72-dfa3-4468-9799-3a2887c5eec8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_25a8d4a0-c295-4455-b841-e8a15b1e39ae" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_1cf0889f-4adf-42dd-87ee-bc483144ba05" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_25a8d4a0-c295-4455-b841-e8a15b1e39ae" xlink:to="loc_us-gaap_ProfitLoss_1cf0889f-4adf-42dd-87ee-bc483144ba05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_5ae77c04-8618-4e18-842b-53d3ce8686b7" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_25a8d4a0-c295-4455-b841-e8a15b1e39ae" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_5ae77c04-8618-4e18-842b-53d3ce8686b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_d56d0311-53e1-45b6-8268-dd2d478027ee" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_8b704dfd-d38c-48c2-8d7a-425c4cf244c6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_d56d0311-53e1-45b6-8268-dd2d478027ee" xlink:to="loc_us-gaap_OperatingIncomeLoss_8b704dfd-d38c-48c2-8d7a-425c4cf244c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_e3a6b725-f950-4bf3-8b5c-a343f3f9411c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_d56d0311-53e1-45b6-8268-dd2d478027ee" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_e3a6b725-f950-4bf3-8b5c-a343f3f9411c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="simple" xlink:href="isrg-20200630.xsd#CondensedConsolidatedStatementsofCashFlowsUnaudited"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e1e20a0c-00ce-48ed-8fb3-e70d164a2c9f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4e80d446-262d-4ff3-a478-06d003325d49" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e1e20a0c-00ce-48ed-8fb3-e70d164a2c9f" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_4e80d446-262d-4ff3-a478-06d003325d49" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_b0969efc-1dab-4f51-b3a0-ceb5a6bfc567" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e1e20a0c-00ce-48ed-8fb3-e70d164a2c9f" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_b0969efc-1dab-4f51-b3a0-ceb5a6bfc567" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_88a05d13-25ab-46de-8c9c-de3bbdb65a65" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e1e20a0c-00ce-48ed-8fb3-e70d164a2c9f" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_88a05d13-25ab-46de-8c9c-de3bbdb65a65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_fcafbd4e-fd54-4c56-ade4-f279336b99de" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e1e20a0c-00ce-48ed-8fb3-e70d164a2c9f" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_fcafbd4e-fd54-4c56-ade4-f279336b99de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_99fb7af2-0255-403b-a25f-7332b006079a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_97a4d060-4334-471b-bf50-a71f29743a4b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_99fb7af2-0255-403b-a25f-7332b006079a" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_97a4d060-4334-471b-bf50-a71f29743a4b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_9831448e-f41c-4506-a6ef-89d9bb830da1" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_99fb7af2-0255-403b-a25f-7332b006079a" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_9831448e-f41c-4506-a6ef-89d9bb830da1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_4686a299-2ac1-4a68-8dbe-142700916d7c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_99fb7af2-0255-403b-a25f-7332b006079a" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_4686a299-2ac1-4a68-8dbe-142700916d7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_422f2d31-8eb5-4932-b265-8475633b3211" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireProductiveAssets"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_99fb7af2-0255-403b-a25f-7332b006079a" xlink:to="loc_us-gaap_PaymentsToAcquireProductiveAssets_422f2d31-8eb5-4932-b265-8475633b3211" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_086cc2d7-625f-49c7-b647-b66a7525f81e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_99fb7af2-0255-403b-a25f-7332b006079a" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_086cc2d7-625f-49c7-b647-b66a7525f81e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a50bcef9-4e7f-453e-a041-bce1630a41c9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_5a13ffdd-bee6-4443-a00a-ee688a994edb" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a50bcef9-4e7f-453e-a041-bce1630a41c9" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_5a13ffdd-bee6-4443-a00a-ee688a994edb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_09742fd6-29c4-4e87-bc93-9958d8a31c71" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a50bcef9-4e7f-453e-a041-bce1630a41c9" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_09742fd6-29c4-4e87-bc93-9958d8a31c71" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMinorityShareholders_c5edcf93-0b70-4cc4-8d29-461a547f6d03" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromMinorityShareholders"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a50bcef9-4e7f-453e-a041-bce1630a41c9" xlink:to="loc_us-gaap_ProceedsFromMinorityShareholders_c5edcf93-0b70-4cc4-8d29-461a547f6d03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_4b5b86a9-1f9e-4e0a-94ef-5f1a8f4b0b96" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a50bcef9-4e7f-453e-a041-bce1630a41c9" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_4b5b86a9-1f9e-4e0a-94ef-5f1a8f4b0b96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_275d64d5-102d-4d0f-8f13-6ca6f765b521" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a50bcef9-4e7f-453e-a041-bce1630a41c9" xlink:to="loc_us-gaap_ProceedsFromStockPlans_275d64d5-102d-4d0f-8f13-6ca6f765b521" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7d08dcbb-80af-4cef-ae65-977d92bf10a3" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_fda28b6d-62f2-4f16-bd2c-0fee240573d9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7d08dcbb-80af-4cef-ae65-977d92bf10a3" xlink:to="loc_us-gaap_ProfitLoss_fda28b6d-62f2-4f16-bd2c-0fee240573d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_784e6838-4901-4e2a-a63d-44e926761f24" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7d08dcbb-80af-4cef-ae65-977d92bf10a3" xlink:to="loc_us-gaap_Depreciation_784e6838-4901-4e2a-a63d-44e926761f24" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_ab0560d7-373d-4e2a-a1cc-55202dc59487" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7d08dcbb-80af-4cef-ae65-977d92bf10a3" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_ab0560d7-373d-4e2a-a1cc-55202dc59487" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_6cd39b9b-ed1f-4412-8b97-423ef9bb3fd8" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7d08dcbb-80af-4cef-ae65-977d92bf10a3" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_6cd39b9b-ed1f-4412-8b97-423ef9bb3fd8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_6535b2ff-59e9-475b-8559-09dbfaf6f0ec" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7d08dcbb-80af-4cef-ae65-977d92bf10a3" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_6535b2ff-59e9-475b-8559-09dbfaf6f0ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_49a086b4-544c-48fe-af85-3d7751a752ea" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7d08dcbb-80af-4cef-ae65-977d92bf10a3" xlink:to="loc_us-gaap_ShareBasedCompensation_49a086b4-544c-48fe-af85-3d7751a752ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalizedContractCostAmortization_10c47562-10c8-4b53-93f0-46386c74cf26" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CapitalizedContractCostAmortization"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7d08dcbb-80af-4cef-ae65-977d92bf10a3" xlink:to="loc_us-gaap_CapitalizedContractCostAmortization_10c47562-10c8-4b53-93f0-46386c74cf26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_bc66b4cb-19ae-4184-8877-3b140857c861" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7d08dcbb-80af-4cef-ae65-977d92bf10a3" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_bc66b4cb-19ae-4184-8877-3b140857c861" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_68574d27-c240-4f65-af3f-266aef2afb65" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7d08dcbb-80af-4cef-ae65-977d92bf10a3" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_68574d27-c240-4f65-af3f-266aef2afb65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_3a8d7968-f928-484f-8a40-f9b688bbf5bf" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7d08dcbb-80af-4cef-ae65-977d92bf10a3" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_3a8d7968-f928-484f-8a40-f9b688bbf5bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_24d07b45-7d7f-410d-86e8-66a6fcf6d714" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7d08dcbb-80af-4cef-ae65-977d92bf10a3" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_24d07b45-7d7f-410d-86e8-66a6fcf6d714" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_bbc1b6ee-14ce-41f4-bb48-ba1e6fc3f483" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7d08dcbb-80af-4cef-ae65-977d92bf10a3" xlink:to="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_bbc1b6ee-14ce-41f4-bb48-ba1e6fc3f483" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_66bcfe3b-9967-4b5a-bf88-715be0e196e3" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7d08dcbb-80af-4cef-ae65-977d92bf10a3" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_66bcfe3b-9967-4b5a-bf88-715be0e196e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_89a057b3-c1df-4dbd-88e4-70557f43ae32" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7d08dcbb-80af-4cef-ae65-977d92bf10a3" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_89a057b3-c1df-4dbd-88e4-70557f43ae32" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/DESCRIPTIONOFTHEBUSINESS" xlink:type="simple" xlink:href="isrg-20200630.xsd#DESCRIPTIONOFTHEBUSINESS"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/DESCRIPTIONOFTHEBUSINESS" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIES" xlink:type="simple" xlink:href="isrg-20200630.xsd#SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIES"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESTables" xlink:type="simple" xlink:href="isrg-20200630.xsd#SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESPolicies" xlink:type="simple" xlink:href="isrg-20200630.xsd#SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESPolicies"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESAmortizedCostBasisbyYearofOriginationandCreditQualityIndicatorDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESAmortizedCostBasisbyYearofOriginationandCreditQualityIndicatorDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESAmortizedCostBasisbyYearofOriginationandCreditQualityIndicatorDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLossWriteoff_7334bb00-9801-44b8-86ed-b20d1b3d19d6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLossWriteoff"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedInCurrentFiscalYearAllowanceForCreditLossWriteoff_2bbd5c9e-c095-4910-8c68-61de0e24630c" xlink:href="isrg-20200630.xsd#isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedInCurrentFiscalYearAllowanceForCreditLossWriteoff"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLossWriteoff_7334bb00-9801-44b8-86ed-b20d1b3d19d6" xlink:to="loc_isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedInCurrentFiscalYearAllowanceForCreditLossWriteoff_2bbd5c9e-c095-4910-8c68-61de0e24630c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedInFiscalYearBeforeLatestFiscalYearAllowanceForCreditLossWriteoff_bf94f971-6c59-4d6d-8cc8-cc64a5279991" xlink:href="isrg-20200630.xsd#isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedInFiscalYearBeforeLatestFiscalYearAllowanceForCreditLossWriteoff"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLossWriteoff_7334bb00-9801-44b8-86ed-b20d1b3d19d6" xlink:to="loc_isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedInFiscalYearBeforeLatestFiscalYearAllowanceForCreditLossWriteoff_bf94f971-6c59-4d6d-8cc8-cc64a5279991" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedThreeYearsBeforeLatestFiscalYearAllowanceForCreditLossWriteoff_5ebbab84-aff5-42d2-9a41-988dfbd30358" xlink:href="isrg-20200630.xsd#isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedThreeYearsBeforeLatestFiscalYearAllowanceForCreditLossWriteoff"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLossWriteoff_7334bb00-9801-44b8-86ed-b20d1b3d19d6" xlink:to="loc_isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedThreeYearsBeforeLatestFiscalYearAllowanceForCreditLossWriteoff_5ebbab84-aff5-42d2-9a41-988dfbd30358" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedFiveOrMoreYearsBeforeLatestFiscalYearAllowanceForCreditLossWriteoff_a94fd067-d4d4-42ca-ad76-a72dce652843" xlink:href="isrg-20200630.xsd#isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedFiveOrMoreYearsBeforeLatestFiscalYearAllowanceForCreditLossWriteoff"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLossWriteoff_7334bb00-9801-44b8-86ed-b20d1b3d19d6" xlink:to="loc_isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedFiveOrMoreYearsBeforeLatestFiscalYearAllowanceForCreditLossWriteoff_a94fd067-d4d4-42ca-ad76-a72dce652843" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedTwoYearsBeforeLatestFiscalYearAllowanceForCreditLossWriteoff_5afb72bc-1924-4460-a485-1c9c4f659cad" xlink:href="isrg-20200630.xsd#isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedTwoYearsBeforeLatestFiscalYearAllowanceForCreditLossWriteoff"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLossWriteoff_7334bb00-9801-44b8-86ed-b20d1b3d19d6" xlink:to="loc_isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedTwoYearsBeforeLatestFiscalYearAllowanceForCreditLossWriteoff_5afb72bc-1924-4460-a485-1c9c4f659cad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedFourYearsBeforeLatestFiscalYearAllowanceForCreditLossWriteoff_7f0a72ad-2724-4ddb-8da3-11922157ae69" xlink:href="isrg-20200630.xsd#isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedFourYearsBeforeLatestFiscalYearAllowanceForCreditLossWriteoff"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLossWriteoff_7334bb00-9801-44b8-86ed-b20d1b3d19d6" xlink:to="loc_isrg_SalesTypeLeaseNetInvestmentInLeaseOriginatedFourYearsBeforeLatestFiscalYearAllowanceForCreditLossWriteoff_7f0a72ad-2724-4ddb-8da3-11922157ae69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_c3ae4e67-39f4-451c-92e3-92fd6f38e277" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLease"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedTwoYearsBeforeLatestFiscalYear_e6276d6c-5de7-44bc-8a56-10a89e7801b9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedTwoYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_c3ae4e67-39f4-451c-92e3-92fd6f38e277" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedTwoYearsBeforeLatestFiscalYear_e6276d6c-5de7-44bc-8a56-10a89e7801b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInFiscalYearBeforeLatestFiscalYear_a92694b3-06f5-4b30-ac2b-c4e13bff7c0a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInFiscalYearBeforeLatestFiscalYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_c3ae4e67-39f4-451c-92e3-92fd6f38e277" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInFiscalYearBeforeLatestFiscalYear_a92694b3-06f5-4b30-ac2b-c4e13bff7c0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInCurrentFiscalYear_8923d087-ccb9-4745-bfef-f522437a2e81" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInCurrentFiscalYear"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_c3ae4e67-39f4-451c-92e3-92fd6f38e277" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedInCurrentFiscalYear_8923d087-ccb9-4745-bfef-f522437a2e81" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedThreeYearsBeforeLatestFiscalYear_03058aa0-c88f-42f0-a5f9-38c84a046b5b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedThreeYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_c3ae4e67-39f4-451c-92e3-92fd6f38e277" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedThreeYearsBeforeLatestFiscalYear_03058aa0-c88f-42f0-a5f9-38c84a046b5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFiveOrMoreYearsBeforeLatestFiscalYear_c1455387-479b-491a-980e-7f582e7c017f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFiveOrMoreYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_c3ae4e67-39f4-451c-92e3-92fd6f38e277" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFiveOrMoreYearsBeforeLatestFiscalYear_c1455387-479b-491a-980e-7f582e7c017f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFourYearsBeforeLatestFiscalYear_57fc7536-5982-4dd4-ab09-7d3248861c85" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFourYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_c3ae4e67-39f4-451c-92e3-92fd6f38e277" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseOriginatedFourYearsBeforeLatestFiscalYear_57fc7536-5982-4dd4-ab09-7d3248861c85" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTS" xlink:type="simple" xlink:href="isrg-20200630.xsd#FINANCIALINSTRUMENTS"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTS" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSTables" xlink:type="simple" xlink:href="isrg-20200630.xsd#FINANCIALINSTRUMENTSTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSSummaryofCashandAvailableForSaleSecuritiesDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#FINANCIALINSTRUMENTSSummaryofCashandAvailableForSaleSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSSummaryofCashandAvailableForSaleSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_1f704c0b-bb64-481f-bb2e-1dbbbdee39ce" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_32247d0a-60cb-406e-a3a9-822cb7dfa126" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_1f704c0b-bb64-481f-bb2e-1dbbbdee39ce" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_32247d0a-60cb-406e-a3a9-822cb7dfa126" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_071a7e99-01c8-45fb-accf-4ee2244df510" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_1f704c0b-bb64-481f-bb2e-1dbbbdee39ce" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_071a7e99-01c8-45fb-accf-4ee2244df510" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_cdbec1e4-4597-44f0-832d-5a9e311b93da" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_1f704c0b-bb64-481f-bb2e-1dbbbdee39ce" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_cdbec1e4-4597-44f0-832d-5a9e311b93da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleAmortizedCost_23fec44f-c160-423d-b907-59048f287ed4" xlink:href="isrg-20200630.xsd#isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleAmortizedCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_4ac091bc-25c8-454f-958c-fc93ca43020c" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleAmortizedCost_23fec44f-c160-423d-b907-59048f287ed4" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_4ac091bc-25c8-454f-958c-fc93ca43020c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_11f2963c-25e1-4427-8534-b31ac2be14dd" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleAmortizedCost_23fec44f-c160-423d-b907-59048f287ed4" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_11f2963c-25e1-4427-8534-b31ac2be14dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleFairValue_5799272d-d67c-4952-953a-2d47c8d083f1" xlink:href="isrg-20200630.xsd#isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleAmortizedCost_23fec44f-c160-423d-b907-59048f287ed4" xlink:to="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleFairValue_5799272d-d67c-4952-953a-2d47c8d083f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleFairValue_fc427926-f99b-4c4e-98a6-1ca76f2da64d" xlink:href="isrg-20200630.xsd#isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_1e3f52f0-c9c6-4b2c-9f7d-5bd7fcb42124" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleFairValue_fc427926-f99b-4c4e-98a6-1ca76f2da64d" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_1e3f52f0-c9c6-4b2c-9f7d-5bd7fcb42124" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSSummaryofCashandAvailableForSaleSecuritiesDetails_1" xlink:type="simple" xlink:href="isrg-20200630.xsd#FINANCIALINSTRUMENTSSummaryofCashandAvailableForSaleSecuritiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSSummaryofCashandAvailableForSaleSecuritiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleAmortizedCost_69e31848-9a02-4ba1-a3ef-7c7d2bc4c778" xlink:href="isrg-20200630.xsd#isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleAmortizedCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_553a5661-5294-4fa3-b337-e37b6e4aa670" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleAmortizedCost_69e31848-9a02-4ba1-a3ef-7c7d2bc4c778" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_553a5661-5294-4fa3-b337-e37b6e4aa670" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_4e5f899b-ece7-4523-ac2e-b391934a15cd" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_isrg_CashandCashEquivalentsandDebtSecuritiesAvailableforsaleAmortizedCost_69e31848-9a02-4ba1-a3ef-7c7d2bc4c778" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_4e5f899b-ece7-4523-ac2e-b391934a15cd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSSummaryofContractualMaturitiesofCashEquivalentsandAvailableForSaleInvestmentsDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#FINANCIALINSTRUMENTSSummaryofContractualMaturitiesofCashEquivalentsandAvailableForSaleInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSSummaryofContractualMaturitiesofCashEquivalentsandAvailableForSaleInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_76d92268-2d48-4444-99bf-e73a15b52f83" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_2980d632-6a9a-443b-a499-826d57b19667" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_76d92268-2d48-4444-99bf-e73a15b52f83" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_2980d632-6a9a-443b-a499-826d57b19667" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_0deefe3f-e9db-4da5-bb0d-305f6123551d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_76d92268-2d48-4444-99bf-e73a15b52f83" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_0deefe3f-e9db-4da5-bb0d-305f6123551d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_AvailableForSaleSecuritiesDebtMaturitiesFairValueTotal_5dac6bf5-c487-4984-8b3b-34c7114f5c0f" xlink:href="isrg-20200630.xsd#isrg_AvailableForSaleSecuritiesDebtMaturitiesFairValueTotal"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_97517d5d-b2b3-4dfd-bca6-992eb80ad9b2" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_isrg_AvailableForSaleSecuritiesDebtMaturitiesFairValueTotal_5dac6bf5-c487-4984-8b3b-34c7114f5c0f" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_97517d5d-b2b3-4dfd-bca6-992eb80ad9b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_09cbe913-1fb8-4f20-9447-4b5818e8c0c9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_isrg_AvailableForSaleSecuritiesDebtMaturitiesFairValueTotal_5dac6bf5-c487-4984-8b3b-34c7114f5c0f" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_09cbe913-1fb8-4f20-9447-4b5818e8c0c9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSDerivativeInstrumentsUsedtoHedgeagainstBalanceSheetForeignCurrencyExposuresDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#FINANCIALINSTRUMENTSDerivativeInstrumentsUsedtoHedgeagainstBalanceSheetForeignCurrencyExposuresDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSDerivativeInstrumentsUsedtoHedgeagainstBalanceSheetForeignCurrencyExposuresDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSGrossNotionalAmountsforOutstandingDerivativesDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#FINANCIALINSTRUMENTSGrossNotionalAmountsforOutstandingDerivativesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/FINANCIALINSTRUMENTSGrossNotionalAmountsforOutstandingDerivativesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATION" xlink:type="simple" xlink:href="isrg-20200630.xsd#BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATION"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATION" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONTables" xlink:type="simple" xlink:href="isrg-20200630.xsd#BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONInventoryDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONInventoryDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_120a7a3f-bf8c-4cb1-b41d-fc90731f58e2" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_f8c48572-7deb-4357-888f-779a7ca5f31d" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_120a7a3f-bf8c-4cb1-b41d-fc90731f58e2" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_f8c48572-7deb-4357-888f-779a7ca5f31d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_73259e0d-6dff-450d-9ac8-ffce4cb1b917" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_120a7a3f-bf8c-4cb1-b41d-fc90731f58e2" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_73259e0d-6dff-450d-9ac8-ffce4cb1b917" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_7f99cd4b-dbf3-4e51-be5a-c3b78b1eeecb" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_120a7a3f-bf8c-4cb1-b41d-fc90731f58e2" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_7f99cd4b-dbf3-4e51-be5a-c3b78b1eeecb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONOtherAccruedLiabilitiesShorttermDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONOtherAccruedLiabilitiesShorttermDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONOtherAccruedLiabilitiesShorttermDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_698a45fb-6184-4778-8329-af6d01cd67fd" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_21626362-7639-42a0-b3ad-f76545829376" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_698a45fb-6184-4778-8329-af6d01cd67fd" xlink:to="loc_us-gaap_TaxesPayableCurrent_21626362-7639-42a0-b3ad-f76545829376" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveCurrent_03fb1b25-a7fe-45b6-9632-2cf09dabe073" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LitigationReserveCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_698a45fb-6184-4778-8329-af6d01cd67fd" xlink:to="loc_us-gaap_LitigationReserveCurrent_03fb1b25-a7fe-45b6-9632-2cf09dabe073" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_e96e940e-cef2-4e76-a0f3-54049cb7bdab" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_698a45fb-6184-4778-8329-af6d01cd67fd" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_e96e940e-cef2-4e76-a0f3-54049cb7bdab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_DeferredPurchaseConsiderationPaymentsCurrent_248ded60-71b4-4e20-bc89-1e34369b9b87" xlink:href="isrg-20200630.xsd#isrg_DeferredPurchaseConsiderationPaymentsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_698a45fb-6184-4778-8329-af6d01cd67fd" xlink:to="loc_isrg_DeferredPurchaseConsiderationPaymentsCurrent_248ded60-71b4-4e20-bc89-1e34369b9b87" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONOtherLongtermLiabilitiesDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONOtherLongtermLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONOtherLongtermLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_a9fd3e98-9a16-4c0d-aefd-209662a2a291" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_bff28f59-b746-471d-b406-6df7dc72c96b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AccruedIncomeTaxesNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_a9fd3e98-9a16-4c0d-aefd-209662a2a291" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_bff28f59-b746-471d-b406-6df7dc72c96b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueNoncurrent_41998606-91b9-4386-8d0f-acad9269fad1" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_DeferredRevenueNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_a9fd3e98-9a16-4c0d-aefd-209662a2a291" xlink:to="loc_us-gaap_DeferredRevenueNoncurrent_41998606-91b9-4386-8d0f-acad9269fad1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesNoncurrent_83bce20d-89b1-4c94-a7c2-5b0e55738b3a" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherAccruedLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_a9fd3e98-9a16-4c0d-aefd-209662a2a291" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesNoncurrent_83bce20d-89b1-4c94-a7c2-5b0e55738b3a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONSupplementalCashFlowInformationDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONSupplementalCashFlowInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/BALANCESHEETDETAILSANDOTHERFINANCIALINFORMATIONSupplementalCashFlowInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/REVENUEANDCONTRACTACQUISITIONCOSTS" xlink:type="simple" xlink:href="isrg-20200630.xsd#REVENUEANDCONTRACTACQUISITIONCOSTS"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/REVENUEANDCONTRACTACQUISITIONCOSTS" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/REVENUEANDCONTRACTACQUISITIONCOSTSTables" xlink:type="simple" xlink:href="isrg-20200630.xsd#REVENUEANDCONTRACTACQUISITIONCOSTSTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/REVENUEANDCONTRACTACQUISITIONCOSTSTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/REVENUEANDCONTRACTACQUISITIONCOSTSRevenueDisaggregatedbyTypesandGeographyDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#REVENUEANDCONTRACTACQUISITIONCOSTSRevenueDisaggregatedbyTypesandGeographyDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/REVENUEANDCONTRACTACQUISITIONCOSTSRevenueDisaggregatedbyTypesandGeographyDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/REVENUEANDCONTRACTACQUISITIONCOSTSAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#REVENUEANDCONTRACTACQUISITIONCOSTSAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/REVENUEANDCONTRACTACQUISITIONCOSTSAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/REVENUEANDCONTRACTACQUISITIONCOSTSAdditionalInformationDetails_1" xlink:type="simple" xlink:href="isrg-20200630.xsd#REVENUEANDCONTRACTACQUISITIONCOSTSAdditionalInformationDetails_1"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/REVENUEANDCONTRACTACQUISITIONCOSTSAdditionalInformationDetails_1" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/REVENUEANDCONTRACTACQUISITIONCOSTSSummaryofContractAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#REVENUEANDCONTRACTACQUISITIONCOSTSSummaryofContractAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/REVENUEANDCONTRACTACQUISITIONCOSTSSummaryofContractAssetsandLiabilitiesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/REVENUEANDCONTRACTACQUISITIONCOSTSSalestypeandOperatingLeaseRevenueDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#REVENUEANDCONTRACTACQUISITIONCOSTSSalestypeandOperatingLeaseRevenueDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/REVENUEANDCONTRACTACQUISITIONCOSTSSalestypeandOperatingLeaseRevenueDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LEASES" xlink:type="simple" xlink:href="isrg-20200630.xsd#LEASES"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LEASES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LEASESTables" xlink:type="simple" xlink:href="isrg-20200630.xsd#LEASESTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LEASESTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LEASESLeaseReceivablesDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#LEASESLeaseReceivablesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LEASESLeaseReceivablesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_26d7a8fa-a123-4375-a006-89e4aea0bc10" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLease"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_SalestypeLeaseDeferredSellingProfit_eb3f6274-ae55-4ad3-ad1f-1fdd96be8fb8" xlink:href="isrg-20200630.xsd#isrg_SalestypeLeaseDeferredSellingProfit"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_26d7a8fa-a123-4375-a006-89e4aea0bc10" xlink:to="loc_isrg_SalestypeLeaseDeferredSellingProfit_eb3f6274-ae55-4ad3-ad1f-1fdd96be8fb8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseLeaseReceivable_8eda561b-ebb2-4b62-b0d1-bf659730739e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseLeaseReceivable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_26d7a8fa-a123-4375-a006-89e4aea0bc10" xlink:to="loc_us-gaap_SalesTypeLeaseLeaseReceivable_8eda561b-ebb2-4b62-b0d1-bf659730739e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLoss_cfbcf528-68d3-4e99-b176-f663934297fc" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLoss"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeLeaseNetInvestmentInLease_26d7a8fa-a123-4375-a006-89e4aea0bc10" xlink:to="loc_us-gaap_SalesTypeLeaseNetInvestmentInLeaseAllowanceForCreditLoss_cfbcf528-68d3-4e99-b176-f663934297fc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/LEASESScheduleofContractualMaturitiesofGrossLeaseReceivablesDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#LEASESScheduleofContractualMaturitiesofGrossLeaseReceivablesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/LEASESScheduleofContractualMaturitiesofGrossLeaseReceivablesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_c607f3b3-bab8-4082-a69b-e79a7c896741" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedRemainderOfFiscalYear_f9ec4c33-5bdd-4167-aef9-95f17a67dd18" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_c607f3b3-bab8-4082-a69b-e79a7c896741" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedRemainderOfFiscalYear_f9ec4c33-5bdd-4167-aef9-95f17a67dd18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedNextTwelveMonths_8e5b2f1c-b715-47ad-823c-6e58371f59eb" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_c607f3b3-bab8-4082-a69b-e79a7c896741" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedNextTwelveMonths_8e5b2f1c-b715-47ad-823c-6e58371f59eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedTwoYears_cb613712-7ef4-49c3-89f4-778900f1bec9" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedTwoYears"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_c607f3b3-bab8-4082-a69b-e79a7c896741" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedTwoYears_cb613712-7ef4-49c3-89f4-778900f1bec9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedThreeYears_2db9e496-9299-42fe-bd3c-4f703bb0d8c6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedThreeYears"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_c607f3b3-bab8-4082-a69b-e79a7c896741" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedThreeYears_2db9e496-9299-42fe-bd3c-4f703bb0d8c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedFourYears_a2eeba78-a0b0-4e92-9802-ca3c139def4b" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedFourYears"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_c607f3b3-bab8-4082-a69b-e79a7c896741" xlink:to="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedFourYears_a2eeba78-a0b0-4e92-9802-ca3c139def4b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedYearFiveAndThereafter_1e200334-9ad3-4d34-9f21-bd7303e88b70" xlink:href="isrg-20200630.xsd#isrg_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedYearFiveAndThereafter"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceived_c607f3b3-bab8-4082-a69b-e79a7c896741" xlink:to="loc_isrg_SalesTypeAndDirectFinancingLeasesLeaseReceivablePaymentsToBeReceivedYearFiveAndThereafter_1e200334-9ad3-4d34-9f21-bd7303e88b70" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/GOODWILLANDINTANGIBLEASSETS" xlink:type="simple" xlink:href="isrg-20200630.xsd#GOODWILLANDINTANGIBLEASSETS"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/GOODWILLANDINTANGIBLEASSETS" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/GOODWILLANDINTANGIBLEASSETSTables" xlink:type="simple" xlink:href="isrg-20200630.xsd#GOODWILLANDINTANGIBLEASSETSTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/GOODWILLANDINTANGIBLEASSETSTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/IntangibleAssetsGoodwillandOtherDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#IntangibleAssetsGoodwillandOtherDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/IntangibleAssetsGoodwillandOtherDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/GOODWILLANDINTANGIBLEASSETSScheduleofSummaryofChangesinGoodwillDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#GOODWILLANDINTANGIBLEASSETSScheduleofSummaryofChangesinGoodwillDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/GOODWILLANDINTANGIBLEASSETSScheduleofSummaryofChangesinGoodwillDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/GOODWILLANDINTANGIBLEASSETSScheduleofIntangibleAssetsDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#GOODWILLANDINTANGIBLEASSETSScheduleofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/GOODWILLANDINTANGIBLEASSETSScheduleofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_42ca7975-1959-4bcd-985c-95d1bad4f176" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_7c6f81bb-3493-4690-8b6a-d0af1d8ed7b6" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_42ca7975-1959-4bcd-985c-95d1bad4f176" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_7c6f81bb-3493-4690-8b6a-d0af1d8ed7b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_ca82da29-c374-4246-a349-3be1ed2af4a2" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_42ca7975-1959-4bcd-985c-95d1bad4f176" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_ca82da29-c374-4246-a349-3be1ed2af4a2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/GOODWILLANDINTANGIBLEASSETSScheduleOfEstimatedFutureAmortizationExpenseOfIntangibleAssetsDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#GOODWILLANDINTANGIBLEASSETSScheduleOfEstimatedFutureAmortizationExpenseOfIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/GOODWILLANDINTANGIBLEASSETSScheduleOfEstimatedFutureAmortizationExpenseOfIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_1025e724-df48-46ba-8a40-1749a89dbbe5" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_e27b5a6c-5a7d-4c45-a217-627807b9d970" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_1025e724-df48-46ba-8a40-1749a89dbbe5" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_e27b5a6c-5a7d-4c45-a217-627807b9d970" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_3ca27ad9-531a-4b30-af74-e4f5a5b2b6a3" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_1025e724-df48-46ba-8a40-1749a89dbbe5" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_3ca27ad9-531a-4b30-af74-e4f5a5b2b6a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_3836d18b-0d50-42fd-8697-0707b4df4234" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_1025e724-df48-46ba-8a40-1749a89dbbe5" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_3836d18b-0d50-42fd-8697-0707b4df4234" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_885f72a0-5fd9-48f0-97c4-71b8934e53e0" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_1025e724-df48-46ba-8a40-1749a89dbbe5" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_885f72a0-5fd9-48f0-97c4-71b8934e53e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_8a5c61f8-3804-4283-8c93-c9b5a2fb84e7" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_1025e724-df48-46ba-8a40-1749a89dbbe5" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_8a5c61f8-3804-4283-8c93-c9b5a2fb84e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFour_ad20cdc3-6fcd-4f2b-91c0-89d088a16456" xlink:href="isrg-20200630.xsd#isrg_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_1025e724-df48-46ba-8a40-1749a89dbbe5" xlink:to="loc_isrg_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFour_ad20cdc3-6fcd-4f2b-91c0-89d088a16456" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/CONTINGENCIES" xlink:type="simple" xlink:href="isrg-20200630.xsd#CONTINGENCIES"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/CONTINGENCIES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/STOCKHOLDERSEQUITY" xlink:type="simple" xlink:href="isrg-20200630.xsd#STOCKHOLDERSEQUITY"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/STOCKHOLDERSEQUITY" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/STOCKHOLDERSEQUITYTables" xlink:type="simple" xlink:href="isrg-20200630.xsd#STOCKHOLDERSEQUITYTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/STOCKHOLDERSEQUITYTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/STOCKHOLDERSEQUITYScheduleofStockholdersEquityDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#STOCKHOLDERSEQUITYScheduleofStockholdersEquityDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/STOCKHOLDERSEQUITYScheduleofStockholdersEquityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/STOCKHOLDERSEQUITYScheduleofShareRepurchaseActivitiesDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#STOCKHOLDERSEQUITYScheduleofShareRepurchaseActivitiesDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/STOCKHOLDERSEQUITYScheduleofShareRepurchaseActivitiesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/STOCKHOLDERSEQUITYStockRepurchaseProgramDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#STOCKHOLDERSEQUITYStockRepurchaseProgramDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/STOCKHOLDERSEQUITYStockRepurchaseProgramDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/STOCKHOLDERSEQUITYComponentsofAccumulatedOtherComprehensiveIncomeNetofTaxDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#STOCKHOLDERSEQUITYComponentsofAccumulatedOtherComprehensiveIncomeNetofTaxDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/STOCKHOLDERSEQUITYComponentsofAccumulatedOtherComprehensiveIncomeNetofTaxDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_4db5acf5-44b5-46ae-8fa9-4cffc24beb8f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_a5c64dbc-0b2b-4feb-bf9f-7ecf02eb0157" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_4db5acf5-44b5-46ae-8fa9-4cffc24beb8f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_a5c64dbc-0b2b-4feb-bf9f-7ecf02eb0157" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationReclassificationAdjustmentFromAOCIRealizedUponSaleOrLiquidationNetOfTax_ce0818cb-19ba-44fe-bc8b-b99487f4c4d1" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationReclassificationAdjustmentFromAOCIRealizedUponSaleOrLiquidationNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_4db5acf5-44b5-46ae-8fa9-4cffc24beb8f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationReclassificationAdjustmentFromAOCIRealizedUponSaleOrLiquidationNetOfTax_ce0818cb-19ba-44fe-bc8b-b99487f4c4d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_2a7fb891-b71d-4a4e-a11b-ea2e89de62a1" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeReclassificationAdjustmentsNetOfTax_16d98293-7b8d-4df8-925b-9b65efd15108" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeReclassificationAdjustmentsNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_2a7fb891-b71d-4a4e-a11b-ea2e89de62a1" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeReclassificationAdjustmentsNetOfTax_16d98293-7b8d-4df8-925b-9b65efd15108" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_9b259a96-8e64-40b0-834a-6c0be11e1f70" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_2a7fb891-b71d-4a4e-a11b-ea2e89de62a1" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_9b259a96-8e64-40b0-834a-6c0be11e1f70" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesNetOfTax_01442c68-d079-4a45-b9b0-746e5b879e82" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_3a222f3c-018a-4864-bcb4-f0a2faccf34e" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesNetOfTax_01442c68-d079-4a45-b9b0-746e5b879e82" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_3a222f3c-018a-4864-bcb4-f0a2faccf34e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIOnDerivativesNetOfTax_45240bc6-299b-43d2-9614-6144f5064bf1" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIOnDerivativesNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossDerivativesQualifyingAsHedgesNetOfTax_01442c68-d079-4a45-b9b0-746e5b879e82" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIOnDerivativesNetOfTax_45240bc6-299b-43d2-9614-6144f5064bf1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansAdjustmentNetOfTaxPortionAttributableToParent_74369ae7-ad99-477b-aa2a-a05f0d662a92" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsNetOfTax_c5aeed51-a075-468c-a811-759c5dcbb3ca" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansAdjustmentNetOfTaxPortionAttributableToParent_74369ae7-ad99-477b-aa2a-a05f0d662a92" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsNetOfTax_c5aeed51-a075-468c-a811-759c5dcbb3ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansNetOfTax_cf35b151-3e26-4caf-a0c7-46dfe8680902" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansAdjustmentNetOfTaxPortionAttributableToParent_74369ae7-ad99-477b-aa2a-a05f0d662a92" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansNetOfTax_cf35b151-3e26-4caf-a0c7-46dfe8680902" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_bff3e05f-6d65-4a62-aba3-9a10fca49580" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_isrg_OtherComprehensiveIncomeLossBeforeReclassificationAdjustmentsNetOfTax_f095dde2-b52a-444f-9402-116cc768379a" xlink:href="isrg-20200630.xsd#isrg_OtherComprehensiveIncomeLossBeforeReclassificationAdjustmentsNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_bff3e05f-6d65-4a62-aba3-9a10fca49580" xlink:to="loc_isrg_OtherComprehensiveIncomeLossBeforeReclassificationAdjustmentsNetOfTax_f095dde2-b52a-444f-9402-116cc768379a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_23d66091-ab5d-42be-8ec7-83b13e00e049" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_bff3e05f-6d65-4a62-aba3-9a10fca49580" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_23d66091-ab5d-42be-8ec7-83b13e00e049" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATION" xlink:type="simple" xlink:href="isrg-20200630.xsd#SHAREBASEDCOMPENSATION"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATION" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATIONTables" xlink:type="simple" xlink:href="isrg-20200630.xsd#SHAREBASEDCOMPENSATIONTables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATIONTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATIONAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#SHAREBASEDCOMPENSATIONAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATIONAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATIONSummaryofStockOptionActivityUnderAllStockPlansDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#SHAREBASEDCOMPENSATIONSummaryofStockOptionActivityUnderAllStockPlansDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATIONSummaryofStockOptionActivityUnderAllStockPlansDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATIONSummaryofRSUActivityDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#SHAREBASEDCOMPENSATIONSummaryofRSUActivityDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATIONSummaryofRSUActivityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATIONStockBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#SHAREBASEDCOMPENSATIONStockBasedCompensationExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATIONStockBasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_f9f7d611-f59e-4e0e-9830-36b8acd23b29" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_c70b2a48-e6aa-4584-8d26-8e082594ff30" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_f9f7d611-f59e-4e0e-9830-36b8acd23b29" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_c70b2a48-e6aa-4584-8d26-8e082594ff30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_74a28487-83ca-44ab-8d8a-b5730d422b47" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_f9f7d611-f59e-4e0e-9830-36b8acd23b29" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_74a28487-83ca-44ab-8d8a-b5730d422b47" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATIONScheduleofEstimatedFairValueofOptionUsingBlackScholesOptionPricingModelWeightedAverageAssumptionsDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#SHAREBASEDCOMPENSATIONScheduleofEstimatedFairValueofOptionUsingBlackScholesOptionPricingModelWeightedAverageAssumptionsDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SHAREBASEDCOMPENSATIONScheduleofEstimatedFairValueofOptionUsingBlackScholesOptionPricingModelWeightedAverageAssumptionsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/INCOMETAXES" xlink:type="simple" xlink:href="isrg-20200630.xsd#INCOMETAXES"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/INCOMETAXES" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/INCOMETAXESAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#INCOMETAXESAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/INCOMETAXESAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/NETINCOMEPERSHARE" xlink:type="simple" xlink:href="isrg-20200630.xsd#NETINCOMEPERSHARE"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/NETINCOMEPERSHARE" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/NETINCOMEPERSHARETables" xlink:type="simple" xlink:href="isrg-20200630.xsd#NETINCOMEPERSHARETables"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/NETINCOMEPERSHARETables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/NETINCOMEPERSHAREComputationofBasicandDilutedNetIncomePerShareDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#NETINCOMEPERSHAREComputationofBasicandDilutedNetIncomePerShareDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/NETINCOMEPERSHAREComputationofBasicandDilutedNetIncomePerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_41563e7a-4eb7-470d-a575-df0e25837487" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_c7654119-776a-456a-92e9-8ceeec1cc175" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_41563e7a-4eb7-470d-a575-df0e25837487" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_c7654119-776a-456a-92e9-8ceeec1cc175" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_2eedbe63-6224-4a59-9af8-095c838b4e9f" xlink:href="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_41563e7a-4eb7-470d-a575-df0e25837487" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_2eedbe63-6224-4a59-9af8-095c838b4e9f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/NETINCOMEPERSHAREAdditionalInformationDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#NETINCOMEPERSHAREAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/NETINCOMEPERSHAREAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SubsequentEvent" xlink:type="simple" xlink:href="isrg-20200630.xsd#SubsequentEvent"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SubsequentEvent" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.intuitivesurgical.com/role/SUBSEQUENTEVENTDetails" xlink:type="simple" xlink:href="isrg-20200630.xsd#SUBSEQUENTEVENTDetails"/>
  <link:calculationLink xlink:role="http://www.intuitivesurgical.com/role/SUBSEQUENTEVENTDetails" xlink:type="extended"/>
</link:linkbase>
