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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Millions
 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Operating activities:    
Net income $ 683.0 $ 958.2
Adjustments to reconcile net income to net cash provided by operating activities:    
Depreciation and loss on disposal of property, plant, and equipment 157.5 132.8
Amortization of intangible assets 12.3 14.5
Gain on sale of business (3.8) 0.0
Loss (gain) on investments, accretion, and amortization, net 33.8 (4.3)
Deferred income taxes (40.1) (24.0)
Share-based compensation expense 247.5 211.3
Amortization of contract acquisition assets 13.6 10.0
Changes in operating assets and liabilities, net of effects of acquisitions:    
Accounts receivable (56.0) (59.6)
Inventory (245.5) (92.4)
Prepaids and other assets (90.1) (177.0)
Accounts payable 12.4 38.2
Accrued compensation and employee benefits (71.5) 19.0
Deferred revenue (3.1) 10.6
Other liabilities 19.7 (17.0)
Net cash provided by operating activities 669.7 1,020.3
Investing activities:    
Purchase of investments (1,376.2) (3,507.7)
Proceeds from sales of investments 0.0 72.1
Proceeds from maturities of investments 1,865.1 2,596.9
Purchase of property, plant, and equipment and intellectual property (225.6) (134.3)
Acquisition of businesses, net of cash, and other investing activities (11.8) (8.7)
Net cash provided by (used in) investing activities 251.5 (981.7)
Financing activities:    
Proceeds from issuance of common stock relating to employee stock plans 106.6 153.7
Taxes paid related to net share settlement of equity awards (179.0) (187.9)
Repurchase of common stock (606.6) 0.0
Payment of deferred purchase consideration (3.0) (9.7)
Net cash used in financing activities (682.0) (43.9)
Effect of exchange rate changes on cash, cash equivalents, and restricted cash 6.0 (2.6)
Net increase (decrease) in cash, cash equivalents, and restricted cash 245.2 (7.9)
Cash, cash equivalents, and restricted cash, beginning of period 1,306.0 1,638.5
Cash, cash equivalents, and restricted cash, end of period $ 1,551.2 $ 1,630.6