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Income Taxes - Schedule Of Deferred Tax Assets (Details) - USD ($) $ in Millions | Dec. 31, 2022 | Dec. 31, 2021
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Deferred tax assets: |  |
Intangible assets | $ 342.8 | $ 369.1
Capitalized research and development expenditures | 172.5 | 4.8
Research and development credits | 156.7 | 98.5
Share-based compensation expense | 121.3 | 110.9
Expenses deducted in later years for tax purposes | 57.5 | 38.4
Lease liabilities | 16.6 | 15.2
Net operating losses | 6.4 | 9.7
Net unrealized losses on available-for-sale securities and other | 45.5 | 5.3
Gross deferred tax assets | 919.3 | 651.9
Valuation allowance | (168.6) | (104.6)
Deferred tax assets | 750.7 | 547.3
Deferred tax liabilities: |  |
Property, plant, and equipment | (64.1) | (79.4)
Right-of-use assets | (11.8) | (12.3)
Intangible assets | (9.3) | (9.7)
Other | (1.0) | (5.1)
Deferred tax liabilities | 86.2 | 106.5
Net deferred tax assets | $ 664.5 | $ 440.8

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