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Fair value measurements (Details Textual) - USD ($) $ in Millions |  | 3 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | --- | ---
Oct. 14, 2015 | Sep. 30, 2017 | Sep. 30, 2017 | Dec. 31, 2016 | Oct. 31, 2015
Business Acquisition [Line Items] |  |  |  |  |
Length of time hedged in foreign currency contracts (or less) |  |  | 3 years |  |
Long-term debt, fair value |  | $ 39,000 | $ 39,000 | $ 36,500 |
Carrying value of debt |  | 35,776 | 35,776 | $ 34,596 |
Dezima [Member] |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Maximum additional consideration due contingent on milestones |  |  |  |  | $ 1,250
Estimated fair values of contingent consideration obligations | $ 110 |  |  |  |
BioVex [Member] |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Additional contingent consideration upon achievement of milestones |  | 325 | $ 325 |  |
Other Government-related and Corporate Debt Securities [Member] |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Investment maturity period |  |  | 5 years |  |
Other operating expenses [Member] | Dezima [Member] | AMG 899 [Member] |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Contingent consideration release |  | $ (116) |  |  |

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