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Collaborations (Details) - Collaborative arrangement with Novartis Pharma AG [Member] - USD ($) | 3 Months Ended | 9 Months Ended |
--- | --- | --- | ---
Sep. 30, 2017 | Sep. 30, 2016 | Sep. 30, 2017 | Sep. 30, 2016 | Apr. 30, 2017
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Potential Future Milestone Payments |  |  |  |  | $ 400,000,000
Research and development expense [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Recovery of Direct Costs | $ 29,000,000 | $ 6,000,000 | $ 86,000,000 | $ 26,000,000 |
Other revenues [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Milestone Payment | $ 60,000,000 |  |  |  |

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