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  <xsd:element id="amgn_NumberofSharesAddedBackforTaxWithholdingonFullValueAwards" name="NumberofSharesAddedBackforTaxWithholdingonFullValueAwards" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
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  <xsd:element id="amgn_PercentageOfCombinedWorldwideGrossRevenuesFromMajorCustomers" name="PercentageOfCombinedWorldwideGrossRevenuesFromMajorCustomers" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
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  <xsd:element id="amgn_PercentageOfNetAmountDueFromCustomersLocatedOutsideDomesticLocation" name="PercentageOfNetAmountDueFromCustomersLocatedOutsideDomesticLocation" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant" />
  <xsd:element id="amgn_PercentageofNetProfitsAfterDeductingCertainPartnerRelatedCosts" name="PercentageofNetProfitsAfterDeductingCertainPartnerRelatedCosts" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_PercentageofPrincipalAmountofNotesthatmaybePaidUponOccurrenceofChangeinControlTriggeringEvent" name="PercentageofPrincipalAmountofNotesthatmaybePaidUponOccurrenceofChangeinControlTriggeringEvent" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
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  <xsd:element id="amgn_ProceedsFromCounterpartiesOnTerminationOfDerivatives" name="ProceedsFromCounterpartiesOnTerminationOfDerivatives" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
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  <xsd:element id="amgn_RelatedPartyTransactionCostRecoveriesFromTransactionsWithRelatedParty" name="RelatedPartyTransactionCostRecoveriesFromTransactionsWithRelatedParty" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="amgn_RentalExpenseOnOperatingLeases" name="RentalExpenseOnOperatingLeases" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_RepathaMember" name="RepathaMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_RestructuringandRelatedCostExpectedCostAcceleratedDepreciationandAssetImpairmentChargesandOtherCosts" name="RestructuringandRelatedCostExpectedCostAcceleratedDepreciationandAssetImpairmentChargesandOtherCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="amgn_RestructuringandRelatedCostExpectedCostSeparationCosts" name="RestructuringandRelatedCostExpectedCostSeparationCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="amgn_RevenueRecognitionMilestoneMethodPotentialFutureMilestonePayment" name="RevenueRecognitionMilestoneMethodPotentialFutureMilestonePayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="amgn_RevenuesEarnedFromMajorCustomersAbstract" name="RevenuesEarnedFromMajorCustomersAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_SanofiRegeneronPatentLitigationMember" name="SanofiRegeneronPatentLitigationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_ScheduleOfIntangibleAssetsTableTextBlock" name="ScheduleOfIntangibleAssetsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_ScheduleOfNotionalAmountsAndInterestRatesForCrossCurrencySwapsTableTextBlock" name="ScheduleOfNotionalAmountsAndInterestRatesForCrossCurrencySwapsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_ScheduleOfU.S.RepatriationTaxCommitments" name="ScheduleOfU.S.RepatriationTaxCommitments" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_ScheduleofLongtermDebtInstrumentsExchangedTableTextBlock" name="ScheduleofLongtermDebtInstrumentsExchangedTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_SensiparMimparaMember" name="SensiparMimparaMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
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  <xsd:element id="amgn_SeparationCosts" name="SeparationCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_SeparationandOtherHeadcountrelatedCostsMember" name="SeparationandOtherHeadcountrelatedCostsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_ShareBasedCompensationArrangementByShareBasedPaymentAwardPerformanceUnitsFairValueAssumptionsTableTextBlock" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPerformanceUnitsFairValueAssumptionsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_SharesCommonStockExcludedFromPublicFloatCalculation" name="SharesCommonStockExcludedFromPublicFloatCalculation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
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  <xsd:element abstract="true" id="amgn_SixPointNineZeroPercentNotesDue2038Member" name="SixPointNineZeroPercentNotesDue2038Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_SixPointOneFivePercentNotesDue2018Member" name="SixPointOneFivePercentNotesDue2018Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_SixPointThreeSevenFivePercentNotesDue2037Member" name="SixPointThreeSevenFivePercentNotesDue2037Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_StateDerivativeLitigationMember" name="StateDerivativeLitigationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_StatementsOfIncomeAndAmountOfGainRecognizedInIncomeForDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsTableTextBlock" name="StatementsOfIncomeAndAmountOfGainRecognizedInIncomeForDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_StatementsOfIncomeAndEffectivePortionOfGainLossReclassifiedFromAccumulatedOtherComprehensiveIncomeIntoIncomeForOurCashFlowHedgeContractsTableTextBlock" name="StatementsOfIncomeAndEffectivePortionOfGainLossReclassifiedFromAccumulatedOtherComprehensiveIncomeIntoIncomeForOurCashFlowHedgeContractsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_StockBasedCompensationExpenseNetOfTax" name="StockBasedCompensationExpenseNetOfTax" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="amgn_StockRepurchaseProgramTableTextBlock" name="StockRepurchaseProgramTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
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  <xsd:element id="amgn_TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateNetDeferredandOtherTaxLiabilitiesProvisionalIncomeTaxExpenseBenefit" name="TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateNetDeferredandOtherTaxLiabilitiesProvisionalIncomeTaxExpenseBenefit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="amgn_TaxCutsAndJobsActOf2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsNetProvisionalIncomeTaxExpenseBenefit" name="TaxCutsAndJobsActOf2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsNetProvisionalIncomeTaxExpenseBenefit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="amgn_TaxCutsAndJobsActof2017IncompleteAccountingNumberofAnnualInstallments" name="TaxCutsAndJobsActof2017IncompleteAccountingNumberofAnnualInstallments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element id="amgn_TaxCutsAndJobsActof2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalLiability" name="TaxCutsAndJobsActof2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="amgn_TaxCutsAndJobsActof2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalLiabilityInFiveYears" name="TaxCutsAndJobsActof2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalLiabilityInFiveYears" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="amgn_TaxCutsAndJobsActof2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalLiabilityInFourYears" name="TaxCutsAndJobsActof2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalLiabilityInFourYears" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="amgn_TaxCutsAndJobsActof2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalLiabilityInThreeYears" name="TaxCutsAndJobsActof2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalLiabilityInThreeYears" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="amgn_TaxCutsAndJobsActof2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalLiabilityInTwoYears" name="TaxCutsAndJobsActof2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalLiabilityInTwoYears" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="amgn_TaxCutsAndJobsActof2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalLiabilityNextTwelveMonths" name="TaxCutsAndJobsActof2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalLiabilityNextTwelveMonths" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="amgn_TaxCutsAndJobsActof2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalLiabilityThereafter" name="TaxCutsAndJobsActof2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalLiabilityThereafter" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="amgn_TermLoanDueTwoThousandEighteenMember" name="TermLoanDueTwoThousandEighteenMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointEightSevenFivePercentNotesDue2021Member" name="ThreePointEightSevenFivePercentNotesDue2021Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointFourFivePercentNotesDue2020Member" name="ThreePointFourFivePercentNotesDue2020Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointOneTwoFivePercentNotesDueTwoZeroTwoFiveMember" name="ThreePointOneTwoFivePercentNotesDueTwoZeroTwoFiveMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointSixTwoFivePercentNotesDue2022Member" name="ThreePointSixTwoFivePercentNotesDue2022Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointSixTwoFivePercentNotesDue2024Member" name="ThreePointSixTwoFivePercentNotesDue2024Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ThreePointTwoZeroNotesDue2027Member" name="ThreePointTwoZeroNotesDue2027Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_ThresholdForDisclosureOfAmountsDueFromMajorCustomers" name="ThresholdForDisclosureOfAmountsDueFromMajorCustomers" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_ThresholdForDisclosureOfProductSalesToMajorCustomers" name="ThresholdForDisclosureOfProductSalesToMajorCustomers" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPercentEuroNotesDueTwoThousandTwentySixMember" name="TwoPercentEuroNotesDueTwoThousandTwentySixMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointFiveZeroPercentNotesDue2016Member" name="TwoPointFiveZeroPercentNotesDue2016Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointOneTwoFivePercentEuroNotesDue2019Member" name="TwoPointOneTwoFivePercentEuroNotesDue2019Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointOneTwoFivePercentNotesDue2017Member" name="TwoPointOneTwoFivePercentNotesDue2017Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointOneTwoFivePercentNotesDueTwoZeroTwoZeroMember" name="TwoPointOneTwoFivePercentNotesDueTwoZeroTwoZeroMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointSevenZeroPercentNotesDueTwoZeroTwoTwoMember" name="TwoPointSevenZeroPercentNotesDueTwoZeroTwoTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointSixFiveNotesDue2022Member" name="TwoPointSixFiveNotesDue2022Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointSixZeroNotesDueTwoZeroTwoSixMember" name="TwoPointSixZeroNotesDueTwoZeroTwoSixMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointThreeZeroPercentNotesDue2016Member" name="TwoPointThreeZeroPercentNotesDue2016Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointTwoFivePercentNotesDueTwoZeroTwoThreeMember" name="TwoPointTwoFivePercentNotesDueTwoZeroTwoThreeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointTwoZeroNotesDue2020Member" name="TwoPointTwoZeroNotesDue2020Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_TwoPointTwoZeroPercentNotesDue2019Member" name="TwoPointTwoZeroPercentNotesDue2019Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_VectibixMember" name="VectibixMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="amgn_XgevaMember" name="XgevaMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="amgn_ZeroPointFortyOnePercentSwissFrancBondsDueTwoThousandTwentyThreeMember" name="ZeroPointFortyOnePercentSwissFrancBondsDueTwoThousandTwentyThreeMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
</xsd:schema>
