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Fair value measurement (Tables) | 12 Months Ended
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Dec. 31, 2017
Fair Value Disclosures [Abstract] |
Fair value of each major class of financial assets and liabilities measured at fair value on a recurring basis | The fair values of each major class of the Company’s financial assets and liabilities measured at fair value on a recurring basis were as follows (in millions):
Fair value measurement as of December 31, 2017, using: |  | Quoted prices in active markets for identical assets (Level 1) |  | Significant other observable inputs (Level 2) |  | Significant unobservable inputs (Level 3) |  | Total
Assets: |  |  |  |  |  |  |  |
Available-for-sale investments: |  |  |  |  |  |  |  |
U.S. Treasury securities |  | $ | 8,242 |  |  | $ | — |  |  | $ | — |  |  | $ | 8,242 |
Other government-related debt securities: |  |  |  |  |  |  |  |
U.S. |  | — |  |  | 223 |  |  | — |  |  | 223 |
Foreign and other |  | — |  |  | 2,422 |  |  | — |  |  | 2,422 |
Corporate debt securities: |  |  |  |  |  |  |  |
Financial |  | — |  |  | 10,072 |  |  | — |  |  | 10,072 |
Industrial |  | — |  |  | 9,670 |  |  | — |  |  | 9,670 |
Other |  | — |  |  | 1,390 |  |  | — |  |  | 1,390 |
Residential mortgage-backed securities |  | — |  |  | 2,168 |  |  | — |  |  | 2,168 |
Other mortgage- and asset-backed securities |  | — |  |  | 2,297 |  |  | — |  |  | 2,297 |
Money market mutual funds |  | 3,245 |  |  | — |  |  | — |  |  | 3,245 |
Other short-term interest-bearing securities |  | — |  |  | 1,440 |  |  | — |  |  | 1,440 |
Equity securities |  | 149 |  |  | — |  |  | — |  |  | 149 |
Derivatives: |  |  |  |  |  |  |  |
Foreign currency contracts |  | — |  |  | 6 |  |  | — |  |  | 6 |
Cross-currency swap contracts |  | — |  |  | 270 |  |  | — |  |  | 270 |
Interest rate swap contracts |  | — |  |  | 10 |  |  | — |  |  | 10 |
Total assets |  | $ | 11,636 |  |  | $ | 29,968 |  |  | $ | — |  |  | $ | 41,604 |
Liabilities: |  |  |  |  |  |  |  |
Derivatives: |  |  |  |  |  |  |  |
Foreign currency contracts |  | $ | — |  |  | $ | 204 |  |  | $ | — |  |  | $ | 204 |
Cross-currency swap contracts |  | — |  |  | 220 |  |  | — |  |  | 220 |
Interest rate swap contracts |  | — |  |  | 61 |  |  | — |  |  | 61 |
Contingent consideration obligations in connection with business combinations |  | — |  |  | — |  |  | 69 |  |  | 69 |
Total liabilities |  | $ | — |  |  | $ | 485 |  |  | $ | 69 |  |  | $ | 554 |
Fair value measurement as of December 31, 2016, using: |  | Quoted prices in active markets for identical assets (Level 1) |  | Significant other observable inputs (Level 2) |  | Significant unobservable inputs (Level 3) |  | Total
Assets: |  |  |  |  |  |  |  |
Available-for-sale investments: |  |  |  |  |  |  |  |
U.S. Treasury securities |  | $ | 6,614 |  |  | $ | — |  |  | $ | — |  |  | $ | 6,614 |
Other government-related debt securities: |  |  |  |  |  |  |  |
U.S. |  | — |  |  | 299 |  |  | — |  |  | 299 |
Foreign and other |  | — |  |  | 1,759 |  |  | — |  |  | 1,759 |
Corporate debt securities: |  |  |  |  |  |  |  |
Financial |  | — |  |  | 8,460 |  |  | — |  |  | 8,460 |
Industrial |  | — |  |  | 8,789 |  |  | — |  |  | 8,789 |
Other |  | — |  |  | 1,077 |  |  | — |  |  | 1,077 |
Residential mortgage-backed securities |  | — |  |  | 1,940 |  |  | — |  |  | 1,940 |
Other mortgage- and asset-backed securities |  | — |  |  | 1,719 |  |  | — |  |  | 1,719 |
Money market mutual funds |  | 2,782 |  |  | — |  |  | — |  |  | 2,782 |
Other short-term interest-bearing securities |  | — |  |  | 4,188 |  |  | — |  |  | 4,188 |
Equity securities |  | 154 |  |  | — |  |  | — |  |  | 154 |
Derivatives: |  |  |  |  |  |  |  |
Foreign currency contracts |  | — |  |  | 203 |  |  | — |  |  | 203 |
Interest rate swap contracts |  | — |  |  | 41 |  |  | — |  |  | 41 |
Total assets |  | $ | 9,550 |  |  | $ | 28,475 |  |  | $ | — |  |  | $ | 38,025 |
Liabilities: |  |  |  |  |  |  |  |
Derivatives: |  |  |  |  |  |  |  |
Foreign currency contracts |  | $ | — |  |  | $ | 4 |  |  | $ | — |  |  | $ | 4 |
Cross-currency swap contracts |  | — |  |  | 523 |  |  | — |  |  | 523 |
Interest rate swap contracts |  | — |  |  | 7 |  |  | — |  |  | 7 |
Contingent consideration obligations in connection with business combinations |  | — |  |  | — |  |  | 179 |  |  | 179 |
Total liabilities |  | $ | — |  |  | $ | 534 |  |  | $ | 179 |  |  | $ | 713 |
Change in carrying amounts of contingent consideration obligations | Changes in the carrying amounts of contingent consideration obligations were as follows (in millions):
| Years ended December 31,
| 2017 |  | 2016 |  | 2015
Beginning balance | $ | 179 |  |  | $ | 188 |  |  | $ | 215 |
Addition from Dezima acquisition | — |  |  | — |  |  | 110 |
Payment to former BioVex Group, Inc. shareholders | — |  |  | — |  |  | (125 | )
Net changes in valuation | (110 | ) |  | (9 | ) |  | (12 | )
Ending balance | $ | 69 |  |  | $ | 179 |  |  | $ | 188 |

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- Definition Tabular disclosure of contingent payment arrangements including the terms that will result in payment and the accounting treatment that will be followed if such contingencies occur, including the potential impact on earnings per share if contingencies are to be settled in common stock of the entity. The description also may include the period over which amounts are expected to be paid, and changes in the amount since the previous reporting period. This also includes contingent options and commitments. + References No definition available. + Details
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- Definition Tabular disclosure of assets and liabilities, including [financial] instruments measured at fair value that are classified in stockholders' equity, if any, that are measured at fair value on a recurring basis. The disclosures contemplated herein include the fair value measurements at the reporting date by the level within the fair value hierarchy in which the fair value measurements in their entirety fall, segregating fair value measurements using quoted prices in active markets for identical assets (Level 1), significant other observable inputs (Level 2), and significant unobservable inputs (Level 3). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19190-110258 + Details
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