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Fair value measurement (Changes in Contingent Consideration Obligation) (Details) - USD ($) $ in Millions | 12 Months Ended
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Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Dezima [Member] |  |  |
Fair Value, Net Derivative Asset (Liability) Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward] |  |  |
Addition from Dezima acquisition | $ 0 |  | $ 110
Net changes in valuation | 116 |  |
Biovex [Member] |  |  |
Fair Value, Net Derivative Asset (Liability) Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward] |  |  |
Settlement of contingent consideration obligations |  |  | (125)
Recurring [Member] |  |  |
Fair Value, Net Derivative Asset (Liability) Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward] |  |  |
Beginning balance | 179 |  |
Ending balance | 69 | $ 179 |
Recurring [Member] | Significant unobservable inputs (Level 3) [Member] |  |  |
Fair Value, Net Derivative Asset (Liability) Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward] |  |  |
Beginning balance | 179 | 188 | 215
Net changes in valuation | (110) | (9) | (12)
Ending balance | 69 | 179 | 188
Recurring [Member] | Significant unobservable inputs (Level 3) [Member] | Dezima [Member] |  |  |
Fair Value, Net Derivative Asset (Liability) Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward] |  |  |
Addition from Dezima acquisition | 0 | 0 | 110
Recurring [Member] | Significant unobservable inputs (Level 3) [Member] | Biovex [Member] |  |  |
Fair Value, Net Derivative Asset (Liability) Measured on Recurring Basis, Unobservable Input Reconciliation [Roll Forward] |  |  |
Settlement of contingent consideration obligations | $ 0 | $ 0 | $ (125)

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- Definition Amount of increase (decrease) in the value of a contingent consideration liability, including, but not limited to, differences arising upon settlement. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 805 -SubTopic 30 -Section 50 -Paragraph 4 -Subparagraph (a)(1) -URI http://asc.fasb.org/extlink&oid=35744584&loc=d3e7008-128479 + Details
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- Definition Amount of liability recognized arising from contingent consideration in a business combination. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 805 -SubTopic 30 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=35744584&loc=d3e6927-128479 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 805 -SubTopic 30 -Section 35 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6911338&loc=d3e6819-128478 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 805 -SubTopic 30 -Section 25 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=6911189&loc=d3e6408-128476 + Details
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