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Business combinations (Details Textual) - USD ($) $ in Millions | 3 Months Ended |  |  |
--- | --- | --- | --- | ---
Mar. 31, 2018 | Sep. 30, 2018 | Dec. 31, 2017 | Dec. 31, 1984
Business Acquisition [Line Items] |  |  |  |
Goodwill |  | $ 14,684 | $ 14,761 |
Kirin-Amgen, Inc. (K-A) [Member] |  |  |  |
Business Acquisition [Line Items] |  |  |  |
Percentage of voting interests acquired | 50.00% |  |  |
Ownership percentage |  |  | 50.00% | 50.00%
Carrying value of equity method investment |  |  | $ 570 |
Kirin-Amgen, Inc. (K-A) [Member] | Kirin [Member] |  |  |  |
Business Acquisition [Line Items] |  |  |  |
Ownership percentage |  |  |  | 50.00%
Kirin-Amgen, Inc. (K-A) [Member] |  |  |  |
Business Acquisition [Line Items] |  |  |  |
Percentage of voting interests acquired | 50.00% |  |  |
Ownership interest in acquiree prior to acquisition (as a percent) | 50.00% |  |  |
Net gain on remeasurement | $ 80 |  |  |
Cash paid | 780 |  |  |
Estimated fair values of contingent consideration obligations | 45 |  |  |
Fair value of assets acquired, cash | 977 |  |  |
Fair value of liabilities assumed, deferred tax liabilities | 102 |  |  |
Fair value of assets acquired and liabilities assumed, net other assets and liabilities | 131 |  |  |
Goodwill | 6 |  |  |
Kirin-Amgen, Inc. (K-A) [Member] | Licensing Rights [Member] |  |  |  |
Business Acquisition [Line Items] |  |  |  |
Fair value of assets acquired, licensing rights | $ 470 |  |  |
Weighted average period of amortization | 4 years |  |  |

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