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Collaborations (Novartis AG) (Details) - USD ($) $ in Millions | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Revenues | $ 23,747 | $ 22,849 | $ 22,991
Other revenues [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Revenues | 1,214 | 1,054 | 1,099
Collaborative Arrangement with Novartis AG [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Potential future milestone payment | 100 |  |
Collaborative Arrangement with Novartis AG [Member] | Other revenues [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Revenues | 295 | 60 |
Collaborative Arrangement with Novartis AG [Member] | Selling, general and administrative [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Cost paid | 44 |  |
Collaborative Arrangement with Novartis AG [Member] | Research and development [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Cost recoveries |  | $ 124 | $ 33
Collaborative Arrangement with Novartis AG [Member] | Cost of sales [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Royalties due | $ 43 |  |

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