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Contingencies and commitments (KYPROLIS ANDA Patent Litigation) (Details) - KYPROLIS (carfilzomib) Patent Litigation [Member] - lawsuit |  |  |  | 12 Months Ended
--- | --- | --- | --- | ---
Sep. 14, 2017 | Nov. 08, 2016 | Nov. 01, 2016 | Dec. 31, 2018
Gain Contingencies [Line Items] |  |  |  |
Number of lawsuits filed | 3 |  |  | 10
Onyx Therapeutics, Inc [Member] |  |  |  |
Gain Contingencies [Line Items] |  |  |  |
Number of lawsuits filed |  | 4 | 4 |

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- Details
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- Details
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