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Contingencies and commitments (KYPROLIS ANDA Patent Litigation) (Details) - KYPROLIS (carfilzomib) Patent Litigation [Member] - lawsuit				12 Months Ended
	Sep. 14, 2017	Nov. 08, 2016	Nov. 01, 2016	Dec. 31, 2018
Gain Contingencies [Line Items]
Number of lawsuits filed	3			10
Onyx Therapeutics, Inc [Member]
Gain Contingencies [Line Items]
Number of lawsuits filed		4	4

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