EX-21 15 exhibit21significantsu.htm SUBSIDIARIES OF THE COMPANY
Exhibit 21
AMGEN INC.
The following is a list of subsidiaries of the Company as of December 31, 2019, omitting some subsidiaries which, considered in the aggregate, would not constitute a significant subsidiary.

SUBSIDIARY |  | STATE OF OTHER JURISDICTION OF
(Name under which subsidiary does business) |  | INCORPORATION OR ORGANIZATION
Amgen Canada Inc. |  | Ontario
Amgen (Europe) GmbH |  | Switzerland
Amgen Fremont Inc. |  | Delaware
Amgen Global Finance B.V. |  | Netherlands
Amgen GmbH Germany |  | Germany
Amgen Holding No. 1 Limited |  | Bermuda
Amgen K-A, Inc. |  | Delaware
Amgen Manufacturing, Limited |  | Bermuda
Amgen Rockville, Inc. |  | Delaware
Amgen S.A.S. |  | France
Amgen SF, LLC |  | Delaware
Amgen Technology (Ireland) Unlimited Company |  | Ireland
Amgen Technology, Limited |  | Bermuda
Amgen USA Inc. |  | Delaware
Amgen Worldwide Holdings B.V. |  | Netherlands
ATL Holdings Limited |  | Bermuda
ATL Holdings II Limited |  | Bermuda
BioVex, Inc. |  | Delaware
Immunex Corporation |  | Washington
Immunex Rhode Island Corporation |  | Delaware
Onyx Pharmaceuticals, Inc. |  | Delaware
Onyx Therapeutics, Inc. |  | Delaware