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Consolidated Statements of Income - USD ($)
shares in Millions, $ in Millions
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Revenues:      
Product sales $ 25,424 $ 23,362 $ 23,747
Total revenues 25,424 23,362 23,747
Operating expenses:      
Cost of sales 6,159 4,356 4,101
Research and development 4,207 4,116 3,737
Selling, general and administrative 5,730 5,150 5,332
Other 189 66 314
Total operating expenses 16,285 13,688 13,484
Operating income 9,139 9,674 10,263
Interest expense, net 1,262 1,289 1,392
Interest and other income, net 256 753 674
Income before income taxes 8,133 9,138 9,545
Provision for income taxes 869 1,296 1,151
Net income $ 7,264 $ 7,842 $ 8,394
Earnings per share:      
Basic (in usd per share) $ 12.40 $ 12.96 $ 12.70
Diluted (in usd per share) $ 12.31 $ 12.88 $ 12.62
Shares used in the calculation of earnings per share:      
Basic (in shares) 586 605 661
Diluted (in shares) 590 609 665
Product sales [Member]      
Revenues:      
Product sales $ 24,240 $ 22,204 $ 22,533
Other [Member]      
Revenues:      
Product sales 1,184 1,158 1,214
Other revenues $ 1,184 $ 1,158 $ 1,214