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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Millions
 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Cash flows from operating activities:    
Net income $ 2,110 $ 3,628
Depreciation, amortization and other 1,696 1,827
Deferred income taxes (137) (261)
Acquired in-process research and development 1,505 0
Other items, net 170 245
Changes in operating assets and liabilities, net of acquisitions:    
Trade receivables, net 35 (1,177)
Inventories (167) (226)
Other assets (258) 143
Accounts payable (156) (216)
Accrued income taxes, net (930) 452
Long-term tax liabilities 47 106
Other liabilities 120 455
Net cash provided by operating activities 4,035 4,976
Cash flows from investing activities:    
Payments to Acquire Businesses, Net of Cash Acquired (1,626) 0
Purchases of marketable securities (8,000) (2,229)
Proceeds from sales of marketable securities 4,404 2,598
Proceeds from maturities of marketable securities 6,528 238
Purchases of property, plant and equipment (351) (300)
Purchases of equity method investments (3) (2,648)
Other (62) (48)
Net cash provided by (used in) investing activities 890 (2,389)
Cash flows from financing activities:    
Net proceeds from issuance of debt 0 9,002
Repayment of debt 0 (5,000)
Repurchases of common stock (2,452) (1,516)
Dividends paid (2,024) (1,887)
Other (85) (78)
Net cash (used in) provided by financing activities (4,561) 521
Increase in cash and cash equivalents 364 3,108
Cash and cash equivalents at beginning of period 6,266 6,037
Cash and cash equivalents at end of period $ 6,630 $ 9,145