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Property, plant and equipment (Schedule) (Details) - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Property, Plant and Equipment [Line Items] |  |  |
Land | $ 279 | $ 259 |
Buildings and improvements | 4,028 | 3,857 |
Manufacturing equipment | 3,080 | 2,865 |
Laboratory equipment | 1,193 | 1,257 |
Fixed equipment | 2,402 | 2,406 |
Capitalized software | 1,151 | 1,216 |
Other | 862 | 1,091 |
Construction in progress | 987 | 915 |
Property, plant and equipment, gross | 13,982 | 13,866 |
Less accumulated depreciation and amortization | (8,798) | (8,977) |
Property, plant and equipment, net | 5,184 | 4,889 |
Depreciation and amortization charges associated with property, plant and equipment | $ 644 | $ 640 | $ 635
Buildings and improvements [Member] | Minimum [Member] |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Useful life (in years) | 10 years |  |
Buildings and improvements [Member] | Maximum [Member] |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Useful life (in years) | 40 years |  |
Manufacturing equipment [Member] | Minimum [Member] |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Useful life (in years) | 8 years |  |
Manufacturing equipment [Member] | Maximum [Member] |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Useful life (in years) | 12 years |  |
Laboratory equipment [Member] | Minimum [Member] |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Useful life (in years) | 8 years |  |
Laboratory equipment [Member] | Maximum [Member] |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Useful life (in years) | 12 years |  |
Fixed equipment [Member] |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Useful life (in years) | 12 years |  |
Capitalized software [Member] | Minimum [Member] |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Useful life (in years) | 3 years |  |
Capitalized software [Member] | Maximum [Member] |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Useful life (in years) | 5 years |  |
Other [Member] | Minimum [Member] |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Useful life (in years) | 5 years |  |
Other [Member] | Maximum [Member] |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Useful life (in years) | 10 years |  |

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- Definition Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.14) -URI http://asc.fasb.org/extlink&oid=120391452&loc=d3e13212-122682 + Details
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- Definition Amount before accumulated depreciation of building structures held for productive use including addition, improvement, or renovation to the structure, including, but not limited to, interior masonry, interior flooring, electrical, and plumbing. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 4 -Subparagraph (f) -URI http://asc.fasb.org/extlink&oid=124098289&loc=d3e6812-107765 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 + Details
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