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Revenues | 12 Months Ended
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Dec. 31, 2021
Revenue from Contract with Customer [Abstract] |
Revenues | Revenues We operate in one business segment: human therapeutics. Therefore, results of our operations are reported on a consolidated basis for purposes of segment reporting, consistent with internal management reporting. Revenues by product and by geographic area, based on customers’ locations, are presented below. The majority of ROW revenues relates to products sold in Europe. Revenues were as follows (in millions):
|  | Year ended December 31, 2021 |  | Year ended December 31, 2020 |  | Year ended December 31, 2019
|  | U.S. |  | ROW |  | Total |  | U.S. |  | ROW |  | Total |  | U.S. |  | ROW |  | Total
Enbrel |  | $ | 4,352 |  |  | $ | 113 |  |  | $ | 4,465 |  |  | $ | 4,855 |  |  | $ | 141 |  |  | $ | 4,996 |  |  | $ | 5,050 |  |  | $ | 176 |  |  | $ | 5,226 |
Prolia |  | 2,150 |  |  | 1,098 |  |  | 3,248 |  |  | 1,830 |  |  | 933 |  |  | 2,763 |  |  | 1,772 |  |  | 900 |  |  | 2,672 |
Otezla(1) |  | 1,804 |  |  | 445 |  |  | 2,249 |  |  | 1,790 |  |  | 405 |  |  | 2,195 |  |  | 139 |  |  | 39 |  |  | 178 |
XGEVA |  | 1,434 |  |  | 584 |  |  | 2,018 |  |  | 1,405 |  |  | 494 |  |  | 1,899 |  |  | 1,457 |  |  | 478 |  |  | 1,935 |
Neulasta |  | 1,514 |  |  | 220 |  |  | 1,734 |  |  | 2,001 |  |  | 292 |  |  | 2,293 |  |  | 2,814 |  |  | 407 |  |  | 3,221 |
Aranesp |  | 537 |  |  | 943 |  |  | 1,480 |  |  | 629 |  |  | 939 |  |  | 1,568 |  |  | 758 |  |  | 971 |  |  | 1,729 |
Repatha |  | 557 |  |  | 560 |  |  | 1,117 |  |  | 459 |  |  | 428 |  |  | 887 |  |  | 376 |  |  | 285 |  |  | 661 |
KYPROLIS |  | 736 |  |  | 372 |  |  | 1,108 |  |  | 710 |  |  | 355 |  |  | 1,065 |  |  | 654 |  |  | 390 |  |  | 1,044 |
Nplate |  | 566 |  |  | 461 |  |  | 1,027 |  |  | 485 |  |  | 365 |  |  | 850 |  |  | 480 |  |  | 315 |  |  | 795 |
Other products |  | 3,636 |  |  | 2,215 |  |  | 5,851 |  |  | 3,821 |  |  | 1,903 |  |  | 5,724 |  |  | 3,031 |  |  | 1,712 |  |  | 4,743 |
Total product sales(2) |  | 17,286 |  |  | 7,011 |  |  | 24,297 |  |  | 17,985 |  |  | 6,255 |  |  | 24,240 |  |  | 16,531 |  |  | 5,673 |  |  | 22,204 |
Other revenues |  | 908 |  |  | 774 |  |  | 1,682 |  |  | 511 |  |  | 673 |  |  | 1,184 |  |  | 693 |  |  | 465 |  |  | 1,158 |
Total revenues |  | $ | 18,194 |  |  | $ | 7,785 |  |  | $ | 25,979 |  |  | $ | 18,496 |  |  | $ | 6,928 |  |  | $ | 25,424 |  |  | $ | 17,224 |  |  | $ | 6,138 |  |  | $ | 23,362 |
____________ (1) Otezla was acquired on November 21, 2019. (2) Hedging gains and losses, which are included in product sales, were not material for the years ended December 31, 2021, 2020 and 2019. In the United States, we sell primarily to pharmaceutical wholesale distributors that we use as the principal means of distributing our products to healthcare providers. Outside the United States, we sell principally to healthcare providers and/or pharmaceutical wholesale distributors depending on the distribution practice in each country. We monitor the financial condition of our larger customers and limit our credit exposure by setting credit limits and, in certain circumstances, by requiring letters of credit or obtaining credit insurance. We had product sales to three customers, each of them accounting for more than 10% of total revenues for each of the years ended December 31, 2021, 2020 and 2019. For the year ended December 31, 2021, on a combined basis, these customers accounted for 82% of total gross revenues as shown in the following table. Certain information with respect to these customers was as follows (dollar amounts in millions):
| Years ended December 31,
| 2021 |  | 2020 |  | 2019
McKesson Corporation: |  |  |  |  |
Gross product sales | $ | 15,187 |  |  | $ | 13,779 |  |  | $ | 11,795 |
% of total gross revenues | 33 | % |  | 32 | % |  | 31 | %
AmerisourceBergen Corporation: |  |  |  |  |
Gross product sales | $ | 14,783 |  |  | $ | 14,743 |  |  | $ | 12,301 |
% of total gross revenues | 32 | % |  | 34 | % |  | 33 | %
Cardinal Health, Inc.: |  |  |  |  |
Gross product sales | $ | 7,681 |  |  | $ | 7,332 |  |  | $ | 6,538 |
% of total gross revenues | 17 | % |  | 17 | % |  | 17 | %
As of December 31, 2021 and 2020, amounts due from these three customers each exceeded 10% of gross trade receivables and accounted for 73% and 74%, respectively, of net trade receivables on a combined basis. As of December 31, 2021 and 2020, 27% and 28%, respectively, of net trade receivables were due from customers located outside the United States, the majority of which were from Europe. Our total allowance for doubtful accounts as of December 31, 2021 and 2020, was not material.

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- Definition The entire disclosure of revenue from contract with customer to transfer good or service and to transfer nonfinancial asset. Includes, but is not limited to, disaggregation of revenue, credit loss recognized from contract with customer, judgment and change in judgment related to contract with customer, and asset recognized from cost incurred to obtain or fulfill contract with customer. Excludes insurance and lease contracts. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -URI http://asc.fasb.org/topic&trid=49130388 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 10 -URI http://asc.fasb.org/extlink&oid=123351226&loc=SL49130551-203045 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 13 -Subparagraph (b)(2) -URI http://asc.fasb.org/extlink&oid=123351226&loc=SL49130556-203045 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 12 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=123351226&loc=SL49130554-203045 Reference 5: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 9 -URI http://asc.fasb.org/extlink&oid=123351226&loc=SL49130550-203045 Reference 6: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 12 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=123351226&loc=SL49130554-203045 Reference 7: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123351226&loc=SL49130554-203045 Reference 8: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 12 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=123351226&loc=SL49130554-203045 Reference 9: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 15 -URI http://asc.fasb.org/extlink&oid=123351226&loc=SL49130558-203045 Reference 10: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=123351226&loc=SL49130554-203045 + Details
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