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Acquisitions - Narrative (Details) $ in Millions |  |  |  |  | 12 Months Ended
--- | --- | --- | --- | --- | ---
Oct. 19, 2021 USD ($) | Apr. 16, 2021 USD ($) | Nov. 21, 2019 USD ($) | Jul. 15, 2019 USD ($) | Dec. 31, 2021 USD ($) market | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($)
Business Acquisition [Line Items] |  |  |  |  |  |  |
Estimated fair values of contingent consideration obligations |  |  |  |  | $ 309 | $ 0 | $ 0
Goodwill |  |  |  |  | 14,890 | 14,689 | 14,703
Cash paid for acquisitions, net of cash acquired |  |  |  |  | 2,529 | 0 | 13,617
Acquired in-process research and development |  |  |  |  | $ 1,505 | $ 0 | $ 0
Estimated blended statutory rate |  |  | 20.00% |  |  |  |
Teneobio |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Cash paid | $ 994 |  |  |  |  |  |
Maximum additional consideration due contingent on certain milestones | 1,600 |  |  |  |  |  |
Estimated fair values of contingent consideration obligations | 309 |  |  |  |  |  |
Fair value of liabilities assumed, deferred tax liabilities | 253 |  |  |  |  |  |
Goodwill | 251 |  |  |  |  |  |
Fair value of assets acquired and liabilities assumed, net other assets and liabilities | 16 |  |  |  |  |  |
Teneobio | R & D Technology rights |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Finite-lived Intangible Assets Acquired | $ 94 |  |  |  |  |  |
Weighted average period of amortization | 10 years |  |  |  |  |  |
Teneobio | Licensing rights |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Finite-lived Intangible Assets Acquired | $ 41 |  |  |  |  |  |
Teneobio | IPR&D |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Acquired in-process research and development | 1,054 |  |  |  |  |  |
Teneobio | IPR&D | AMG 340 |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Acquired in-process research and development | $ 784 |  |  |  |  |  |
Five Prime Therapeutics, Inc. |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Cash paid for acquisitions, net of cash acquired |  | $ 1,600 |  |  |  |  |
Acquired in-process research and development |  | 1,500 |  |  |  |  |
Deferred tax assets |  | 177 |  |  |  |  |
Other liabilities |  | $ 47 |  |  |  |  |
Otezla |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Cash paid |  |  | $ 13,400 |  |  |  |
Fair value of liabilities assumed, deferred tax liabilities |  |  | 24 |  |  |  |
Approved markets | market |  |  |  |  | 50 |  |
Adjustments to carrying value of intangible assets |  |  | 119 |  |  |  |
Adjustments to deferred tax liability |  |  | 24 |  |  |  |
Adjustments to deferred credit |  |  | $ 96 |  |  |  |
Otezla | Inventories |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Acquired assets, weighted useful life |  |  |  |  | 2 years 6 months |  |
Otezla | Developed Technology Rights |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Weighted average period of amortization |  |  | 8 years 6 months |  |  |  |
Otezla | Marketing-Related Rights | Assembled Workforce |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Weighted average period of amortization |  |  | 5 years |  |  |  |
Nuevolution |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Fair value of liabilities assumed, deferred tax liabilities |  |  |  | $ 22 |  |  |
Goodwill |  |  |  | 26 |  |  |
Consideration transferred |  |  |  | 183 |  |  |
Fair value of assets acquired and liabilities assumed, net other assets and liabilities |  |  |  | 29 |  |  |
Nuevolution | R & D Technology rights |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Finite-lived Intangible Assets Acquired |  |  |  | $ 150 |  |  |
Weighted average period of amortization |  |  |  | 10 years |  |  |

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