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Collaborations - BeiGene (Details) - USD ($) |  | 12 Months Ended
--- | --- | ---
Jan. 02, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Revenue from Contract with Customer, Including Assessed Tax |  | $ 25,979,000,000 | $ 25,424,000,000 | $ 23,362,000,000
BeiGene |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Ownership percentage | 20.50% | 18.40% | 20.50% |
Equity Method Investment, Aggregate Cost | $ 2,800,000,000 |  |  |
BeiGene |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Research and Development Arrangement, Contract to Perform for Others, Costs Incurred, Gross | $ 1,250,000,000 |  |  |
BeiGene | Other current assets [Member] |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Related Party Transaction, Due from (to) Related Party |  | $ 61,000,000 | $ 99,000,000 |
BeiGene | Trade Accounts Receivable |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Related Party Transaction, Due from (to) Related Party |  | 21,000,000 | 22,000,000 |
BeiGene | Research and Development Expense [Member] |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Cost recoveries |  | 220,000,000 | $ 225,000,000 |
BeiGene | Selling, general and administrative [Member] |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Profit and loss share of expenses |  | 64,000,000 |  |
BeiGene | BeiGene |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Revenue from Contract with Customer, Including Assessed Tax |  | $ 72,000,000 |  |

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