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Collaborations - Novartis AG (Details) - Collaborative Arrangement with Novartis AG [Member] - USD ($) $ in Millions | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Potential future milestone payment | $ 100 |  |
Selling, general and administrative [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Cost recoveries | 160 | $ 192 | $ 187
Cost of sales [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Royalties due | $ 116 | $ 139 | $ 115

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