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Consolidated Statements of Income - USD ($)
shares in Millions, $ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Revenues:      
Total revenues $ 25,979 $ 25,424 $ 23,362
Operating expenses:      
Cost of sales 6,454 6,159 4,356
Research and development 4,819 4,207 4,116
Acquired in-process research and development 1,505 0 0
Selling, general and administrative 5,368 5,730 5,150
Other 194 189 66
Total operating expenses 18,340 16,285 13,688
Operating income 7,639 9,139 9,674
Interest expense, net (1,197) (1,262) (1,289)
Other income, net 259 256 753
Income before income taxes 6,701 8,133 9,138
Provision for income taxes 808 869 1,296
Net income $ 5,893 $ 7,264 $ 7,842
Earnings per share:      
Basic (in usd per share) $ 10.34 $ 12.40 $ 12.96
Diluted (in usd per share) $ 10.28 $ 12.31 $ 12.88
Shares used in the calculation of earnings per share:      
Basic (in shares) 570 586 605
Diluted (in shares) 573 590 609
Product sales      
Revenues:      
Total revenues $ 24,297 $ 24,240 $ 22,204
Other revenues      
Revenues:      
Total revenues $ 1,682 $ 1,184 $ 1,158