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Acquisitions - Narrative (Details) $ in Millions					12 Months Ended
	Oct. 19, 2021 USD ($)	Apr. 16, 2021 USD ($)	Nov. 21, 2019 USD ($)	Jul. 15, 2019 USD ($)	Dec. 31, 2021 USD ($) market	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Business Acquisition [Line Items]
Estimated fair values of contingent consideration obligations					$ 309	$ 0	$ 0
Goodwill					14,890	14,689	14,703
Cash paid for acquisitions, net of cash acquired					2,529	0	13,617
Acquired in-process research and development					$ 1,505	$ 0	$ 0
Estimated blended statutory rate			20.00%
Teneobio
Business Acquisition [Line Items]
Cash paid	$ 994
Maximum additional consideration due contingent on certain milestones	1,600
Estimated fair values of contingent consideration obligations	309
Fair value of liabilities assumed, deferred tax liabilities	253
Goodwill	251
Fair value of assets acquired and liabilities assumed, net other assets and liabilities	16
Teneobio | R & D Technology rights
Business Acquisition [Line Items]
Finite-lived Intangible Assets Acquired	$ 94
Weighted average period of amortization	10 years
Teneobio | Licensing rights
Business Acquisition [Line Items]
Finite-lived Intangible Assets Acquired	$ 41
Teneobio | IPR&D
Business Acquisition [Line Items]
Acquired in-process research and development	1,054
Teneobio | IPR&D | AMG 340
Business Acquisition [Line Items]
Acquired in-process research and development	$ 784
Five Prime Therapeutics, Inc.
Business Acquisition [Line Items]
Cash paid for acquisitions, net of cash acquired		$ 1,600
Acquired in-process research and development		1,500
Deferred tax assets		177
Other liabilities		$ 47
Otezla
Business Acquisition [Line Items]
Cash paid			$ 13,400
Fair value of liabilities assumed, deferred tax liabilities			24
Approved markets | market					50
Adjustments to carrying value of intangible assets			119
Adjustments to deferred tax liability			24
Adjustments to deferred credit			$ 96
Otezla | Inventories
Business Acquisition [Line Items]
Acquired assets, weighted useful life					2 years 6 months
Otezla | Developed Technology Rights
Business Acquisition [Line Items]
Weighted average period of amortization			8 years 6 months
Otezla | Marketing-Related Rights | Assembled Workforce
Business Acquisition [Line Items]
Weighted average period of amortization			5 years
Nuevolution
Business Acquisition [Line Items]
Fair value of liabilities assumed, deferred tax liabilities				$ 22
Goodwill				26
Consideration transferred				183
Fair value of assets acquired and liabilities assumed, net other assets and liabilities				29
Nuevolution | R & D Technology rights
Business Acquisition [Line Items]
Finite-lived Intangible Assets Acquired				$ 150
Weighted average period of amortization				10 years

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