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Revenues - Narrative (Details)
$ in Millions
 12 Months Ended
Dec. 31, 2021
USD ($)
segment
customer
Dec. 31, 2020
USD ($)
customer
Dec. 31, 2019
USD ($)
customer
Revenue from Contract with Customer [Abstract]      
Number of operating segments | segment 1    
Revenue from External Customer [Line Items]      
Number of major customers (as defined) accounting for more than 10% of total revenue | customer 3 3 3
Major customers (as defined) accounting for more than 10% of gross trade receivables | customer 3 3  
Combined trade receivables for all major customers (as defined) as a percentage of net trade receivables 73.00% 74.00%  
Percentage of worldwide gross revenues derived from major customers (as defined) on a combined basis 82.00%    
Total product sales $ 25,979 $ 25,424 $ 23,362
Percentage of net trade receivables due from customers located outside the United States, primarily in Europe 27.00% 28.00%  
US [Member]      
Revenue from External Customer [Line Items]      
Total product sales $ 18,194 $ 18,496 17,224
ROW [Member]      
Revenue from External Customer [Line Items]      
Total product sales 7,785 6,928 6,138
Product sales      
Revenue from External Customer [Line Items]      
Total product sales 24,297 24,240 22,204
Product sales | US [Member]      
Revenue from External Customer [Line Items]      
Total product sales 17,286 17,985 16,531
Product sales | ROW [Member]      
Revenue from External Customer [Line Items]      
Total product sales 7,011 6,255 5,673
Enbrel® (etanercept) [Member]      
Revenue from External Customer [Line Items]      
Total product sales 4,465 4,996 5,226
Enbrel® (etanercept) [Member] | US [Member]      
Revenue from External Customer [Line Items]      
Total product sales 4,352 4,855 5,050
Enbrel® (etanercept) [Member] | ROW [Member]      
Revenue from External Customer [Line Items]      
Total product sales 113 141 176
Prolia® (denosumab) [Member]      
Revenue from External Customer [Line Items]      
Total product sales 3,248 2,763 2,672
Prolia® (denosumab) [Member] | US [Member]      
Revenue from External Customer [Line Items]      
Total product sales 2,150 1,830 1,772
Prolia® (denosumab) [Member] | ROW [Member]      
Revenue from External Customer [Line Items]      
Total product sales 1,098 933 900
Otezla [Member]      
Revenue from External Customer [Line Items]      
Total product sales 2,249 2,195 178
Otezla [Member] | US [Member]      
Revenue from External Customer [Line Items]      
Total product sales 1,804 1,790 139
Otezla [Member] | ROW [Member]      
Revenue from External Customer [Line Items]      
Total product sales 445 405 39
XGEVA® (denosumab) [Member]      
Revenue from External Customer [Line Items]      
Total product sales 2,018 1,899 1,935
XGEVA® (denosumab) [Member] | US [Member]      
Revenue from External Customer [Line Items]      
Total product sales 1,434 1,405 1,457
XGEVA® (denosumab) [Member] | ROW [Member]      
Revenue from External Customer [Line Items]      
Total product sales 584 494 478
Neulasta® (pegfilgrastim) [Member]      
Revenue from External Customer [Line Items]      
Total product sales 1,734 2,293 3,221
Neulasta® (pegfilgrastim) [Member] | US [Member]      
Revenue from External Customer [Line Items]      
Total product sales 1,514 2,001 2,814
Neulasta® (pegfilgrastim) [Member] | ROW [Member]      
Revenue from External Customer [Line Items]      
Total product sales 220 292 407
Aranesp® (darbepoetin alfa) [Member]      
Revenue from External Customer [Line Items]      
Total product sales 1,480 1,568 1,729
Aranesp® (darbepoetin alfa) [Member] | US [Member]      
Revenue from External Customer [Line Items]      
Total product sales 537 629 758
Aranesp® (darbepoetin alfa) [Member] | ROW [Member]      
Revenue from External Customer [Line Items]      
Total product sales 943 939 971
Repatha (evolocumab) [Member]      
Revenue from External Customer [Line Items]      
Total product sales 1,117 887 661
Repatha (evolocumab) [Member] | US [Member]      
Revenue from External Customer [Line Items]      
Total product sales 557 459 376
Repatha (evolocumab) [Member] | ROW [Member]      
Revenue from External Customer [Line Items]      
Total product sales 560 428 285
Kyprolis [Member]      
Revenue from External Customer [Line Items]      
Total product sales 1,108 1,065 1,044
Kyprolis [Member] | US [Member]      
Revenue from External Customer [Line Items]      
Total product sales 736 710 654
Kyprolis [Member] | ROW [Member]      
Revenue from External Customer [Line Items]      
Total product sales 372 355 390
Nplate      
Revenue from External Customer [Line Items]      
Total product sales 1,027 850 795
Nplate | US [Member]      
Revenue from External Customer [Line Items]      
Total product sales 566 485 480
Nplate | ROW [Member]      
Revenue from External Customer [Line Items]      
Total product sales 461 365 315
Other products [Member]      
Revenue from External Customer [Line Items]      
Total product sales 5,851 5,724 4,743
Other products [Member] | US [Member]      
Revenue from External Customer [Line Items]      
Total product sales 3,636 3,821 3,031
Other products [Member] | ROW [Member]      
Revenue from External Customer [Line Items]      
Total product sales 2,215 1,903 1,712
Other revenues [Member]      
Revenue from External Customer [Line Items]      
Total product sales 1,682 1,184 1,158
Other revenues [Member] | US [Member]      
Revenue from External Customer [Line Items]      
Total product sales 908 511 693
Other revenues [Member] | ROW [Member]      
Revenue from External Customer [Line Items]      
Total product sales 774 673 465
AmerisourceBergen Corporation [Member] | Product sales      
Revenue from External Customer [Line Items]      
Total product sales 14,783 14,743 12,301
McKesson Corporation [Member] | Product sales      
Revenue from External Customer [Line Items]      
Total product sales 15,187 13,779 11,795
Cardinal Health, Inc. [Member] | Product sales      
Revenue from External Customer [Line Items]      
Total product sales $ 7,681 $ 7,332 $ 6,538