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Fair value measurement (Details Textual) - USD ($) $ in Millions | 6 Months Ended |
--- | --- | ---
Jun. 30, 2022 | Dec. 31, 2021
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Length of time hedged in foreign currency contracts (or less) | 3 years |
Long-term debt, fair value | $ 34,400 | $ 37,900
Carrying value of debt | 36,522 | 33,309
Collaborative arrangement with BeiGene, Ltd. [Member] |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Equity Method Investments,Quoted Market Price | 3,100 | 5,100
Carrying value of equity method investment | 2,500 | 2,800
Teneobio Inc. |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Maximum additional consideration due contingent on certain milestones | $ 1,600 | $ 1,600

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