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Revenues (Details) $ in Millions | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2022 USD ($) | Jun. 30, 2021 USD ($) | Jun. 30, 2022 USD ($) segment | Jun. 30, 2021 USD ($)
Revenue from Contract with Customer [Abstract] |  |  |  |
Number of operating segments | segment |  |  | 1 |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | $ 6,594 | $ 6,526 | $ 12,832 | $ 12,427
Product sales [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 6,281 | 6,114 | 12,012 | 11,706
Product sales [Member] | US [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 4,446 | 4,374 | 8,483 | 8,277
Product sales [Member] | ROW [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 1,835 | 1,740 | 3,529 | 3,429
Enbrel® (etanercept) [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 1,051 | 1,144 | 1,913 | 2,068
Enbrel® (etanercept) [Member] | US [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 1,036 | 1,113 | 1,879 | 2,007
Enbrel® (etanercept) [Member] | ROW [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 15 | 31 | 34 | 61
Prolia® (denosumab) [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 922 | 814 | 1,774 | 1,572
Prolia® (denosumab) [Member] | US [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 611 | 538 | 1,193 | 1,039
Prolia® (denosumab) [Member] | ROW [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 311 | 276 | 581 | 533
Otezla (apremilast) [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 594 | 534 | 1,045 | 1,010
Otezla (apremilast) [Member] | US [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 487 | 423 | 837 | 789
Otezla (apremilast) [Member] | ROW [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 107 | 111 | 208 | 221
XGEVA® (denosumab) [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 533 | 488 | 1,035 | 956
XGEVA® (denosumab) [Member] | US [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 391 | 355 | 759 | 689
XGEVA® (denosumab) [Member] | ROW [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 142 | 133 | 276 | 267
Aranesp® (darbepoetin alfa) [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 357 | 367 | 715 | 722
Aranesp® (darbepoetin alfa) [Member] | US [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 132 | 135 | 269 | 260
Aranesp® (darbepoetin alfa) [Member] | ROW [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 225 | 232 | 446 | 462
Neulasta® (pegfilgrastim) [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 310 | 486 | 658 | 968
Neulasta® (pegfilgrastim) [Member] | US [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 263 | 434 | 567 | 855
Neulasta® (pegfilgrastim) [Member] | ROW [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 47 | 52 | 91 | 113
Repatha (evolocumab) [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 325 | 286 | 654 | 572
Repatha (evolocumab) [Member] | US [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 154 | 143 | 319 | 282
Repatha (evolocumab) [Member] | ROW [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 171 | 143 | 335 | 290
KYPROLIS® (carfilzomib) [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 317 | 280 | 604 | 531
KYPROLIS® (carfilzomib) [Member] | US [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 213 | 190 | 409 | 349
KYPROLIS® (carfilzomib) [Member] | ROW [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 104 | 90 | 195 | 182
Nplate [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 284 | 245 | 550 | 472
Nplate [Member] | US [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 156 | 136 | 312 | 248
Nplate [Member] | ROW [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 128 | 109 | 238 | 224
Other products [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 1,588 | 1,470 | 3,064 | 2,835
Other products [Member] | US [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 1,003 | 907 | 1,939 | 1,759
Other products [Member] | ROW [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | 585 | 563 | 1,125 | 1,076
Other revenues [Member] |  |  |  |
Revenue from External Customer [Line Items] |  |  |  |
Total revenues | $ 313 | $ 412 | $ 820 | $ 721

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