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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Millions
 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Cash flows from operating activities:    
Net income $ 2,793 $ 2,110
Depreciation, amortization and other 1,669 1,696
Deferred income taxes (514) (137)
Acquired in-process research and development 0 1,505
Adjustments for equity method investments 497 (36)
Loss on divestiture 560 0
Other items, net 436 206
Changes in operating assets and liabilities, net of acquisitions:    
Trade receivables, net (504) 35
Inventories (410) (167)
Other assets 198 (258)
Accounts payable (98) (156)
Accrued income taxes, net (685) (930)
Long-term tax liabilities 108 47
Other liabilities 44 120
Net cash provided by operating activities 4,094 4,035
Cash flows from investing activities:    
Purchases of marketable securities (1,976) (8,000)
Proceeds from sales of marketable securities 0 4,404
Proceeds from maturities of marketable securities 47 6,528
Purchases of property, plant and equipment (436) (351)
Cash paid for acquisitions, net of cash acquired 0 (1,626)
Other 61 (65)
Net cash (used in) provided by investing activities (2,304) 890
Cash flows from financing activities:    
Net proceeds from issuance of debt 3,954 0
Repurchases of common stock (Note 10) (6,360) (2,452)
Dividends paid (2,118) (2,024)
Other (52) (85)
Net cash used in financing activities (4,576) (4,561)
(Decrease) increase in cash and cash equivalents (2,786) 364
Cash and cash equivalents at beginning of period 7,989 6,266
Cash and cash equivalents at end of period $ 5,203 $ 6,630