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Acquisitions and divestitures - Narrative (Details) - USD ($) $ in Millions |  |  | 3 Months Ended | 9 Months Ended |
--- | --- | --- | --- | --- | ---
Jun. 28, 2022 | Apr. 16, 2021 | Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021 | Dec. 31, 2021
Business Acquisition [Line Items] |  |  |  |  |  |  |
Adjustments to goodwill resulting from acquisitions and divestitures, net |  |  |  |  | $ 6 |  |
Goodwill |  |  | $ 14,845 |  | 14,845 |  | $ 14,890
Payments to acquire business |  |  |  |  | 0 | $ 1,639 |
Acquired in-process research and development |  |  | 0 | $ 0 | 0 | 1,505 |
Loss on divestiture |  |  |  |  | 565 | $ 0 |
Gensenta Ilac Sanayi vs Ticaret |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Proceeds from divestiture of business | $ 135 |  |  |  |  |  |
Including discontinued operation, assets | $ 76 |  |  |  |  |  |
Held-for-sale assets |  |  | 94 |  | 94 |  |
Held-for-sale liabilities |  |  | 18 |  | 18 |  |
Gensenta Ilac Sanayi vs Ticaret | Other Operating Income (Expense) |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Loss on divestiture |  |  |  |  | 565 |  |
Teneobio |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Adjustments to goodwill resulting from acquisitions and divestitures, net |  |  |  |  | 22 |  |
Cash purchase price |  |  |  |  | 993 |  |
Maximum additional consideration due contingent on certain milestones |  |  | 1,600 |  | 1,600 |  |
Contingent consideration |  |  |  |  | 299 |  |
Acquired in-process research and development |  |  | 991 |  | 991 |  |
Deferred tax liability |  |  | 244 |  | 244 |  |
Goodwill |  |  | 273 |  | 273 |  |
Teneobio | R & D Technology rights |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Value of intangible assets acquired |  |  |  |  | $ 115 |  |
Weighted average period of amortization |  |  |  |  | 10 years |  |
Teneobio | Licensing rights |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Value of intangible assets acquired |  |  |  |  | $ 41 |  |
Teneobio | In-process research and development | AMG 340 |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Acquired in-process research and development |  |  | $ 784 |  | $ 784 |  |
Five Prime Therapeutics, Inc. |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |
Payments to acquire business |  | $ 1,600 |  |  |  |  |
Acquired in-process research and development |  | 1,500 |  |  |  |  |
Deferred tax asset |  | 177 |  |  |  |  |
Other liabilities |  | $ 47 |  |  |  |  |

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