EX-21 8 amgn-ex21_20221231xq4.htm SUBSIDIARIES OF THE COMPANY
Exhibit 21
AMGEN INC.
The following is a list of subsidiaries of the Company as of December 31, 2022, omitting some subsidiaries which, considered in the aggregate, would not constitute a significant subsidiary.

SUBSIDIARY |  | STATE OR OTHER JURISDICTION OF
(Name under which subsidiary does business) |  | INCORPORATION OR ORGANIZATION
Amgen (Europe) GmbH |  | Switzerland
Amgen Canada Inc. |  | Canada
Amgen Fremont Inc. |  | Delaware
Amgen Global Finance B.V. |  | Netherlands
Amgen GmbH Germany |  | Germany
Amgen Ilaç Ticaret Limited Şirketi |  | Turkey
Amgen K-A, Inc. |  | Delaware
Amgen Manufacturing, Limited |  | Bermuda
Amgen Research (Munich) GmbH |  | Germany
Amgen S.A.S. |  | France
Amgen S.p.A. |  | Italy
Amgen SF, LLC |  | Delaware
Amgen Singapore Manufacturing Pte. Ltd. |  | Singapore
Amgen Technology (Ireland) Unlimited Company |  | Ireland
Amgen Technology, Limited |  | Bermuda
Amgen USA Inc. |  | Delaware
Amgen Worldwide Holdings B.V. |  | Netherlands
Amgen, S.A. |  | Spain
BioVex Limited |  | United Kingdom
BioVex, Inc. |  | Delaware
ChemoCentryx, Inc. |  | Delaware
Five Prime Therapeutics Inc. |  | Delaware
Immunex Corporation |  | Washington
Immunex Rhode Island Corporation |  | Delaware
Onyx Pharmaceuticals, Inc. |  | Delaware
Onyx Therapeutics, Inc. |  | Delaware
Saga Investments Coöperatief U.A. |  | Netherlands
TeneoBio, Inc. |  | Delaware