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Revenues | 12 Months Ended
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Dec. 31, 2022
Revenue from Contract with Customer [Abstract] |
Revenues | Revenues We operate in one business segment: human therapeutics. Therefore, results of our operations are reported on a consolidated basis for purposes of segment reporting, consistent with internal management reporting. Revenues by product and by geographic area, based on customers’ locations, are presented below. The majority of ROW revenues relates to products sold in Europe. Revenues were as follows (in millions):
|  | Year ended December 31, 2022 |  | Year ended December 31, 2021 |  | Year ended December 31, 2020
|  | U.S. |  | ROW |  | Total |  | U.S. |  | ROW |  | Total |  | U.S. |  | ROW |  | Total
ENBREL |  | $ | 4,044 |  |  | $ | 73 |  |  | $ | 4,117 |  |  | $ | 4,352 |  |  | $ | 113 |  |  | $ | 4,465 |  |  | $ | 4,855 |  |  | $ | 141 |  |  | $ | 4,996 |
Prolia |  | 2,465 |  |  | 1,163 |  |  | 3,628 |  |  | 2,150 |  |  | 1,098 |  |  | 3,248 |  |  | 1,830 |  |  | 933 |  |  | 2,763 |
Otezla |  | 1,886 |  |  | 402 |  |  | 2,288 |  |  | 1,804 |  |  | 445 |  |  | 2,249 |  |  | 1,790 |  |  | 405 |  |  | 2,195 |
XGEVA |  | 1,480 |  |  | 534 |  |  | 2,014 |  |  | 1,434 |  |  | 584 |  |  | 2,018 |  |  | 1,405 |  |  | 494 |  |  | 1,899 |
Aranesp |  | 521 |  |  | 900 |  |  | 1,421 |  |  | 537 |  |  | 943 |  |  | 1,480 |  |  | 629 |  |  | 939 |  |  | 1,568 |
Nplate |  | 848 |  |  | 459 |  |  | 1,307 |  |  | 566 |  |  | 461 |  |  | 1,027 |  |  | 485 |  |  | 365 |  |  | 850 |
Repatha |  | 608 |  |  | 688 |  |  | 1,296 |  |  | 557 |  |  | 560 |  |  | 1,117 |  |  | 459 |  |  | 428 |  |  | 887 |
KYPROLIS |  | 850 |  |  | 397 |  |  | 1,247 |  |  | 736 |  |  | 372 |  |  | 1,108 |  |  | 710 |  |  | 355 |  |  | 1,065 |
Neulasta |  | 959 |  |  | 167 |  |  | 1,126 |  |  | 1,514 |  |  | 220 |  |  | 1,734 |  |  | 2,001 |  |  | 292 |  |  | 2,293 |
EVENITY |  | 533 |  |  | 254 |  |  | 787 |  |  | 331 |  |  | 199 |  |  | 530 |  |  | 191 |  |  | 159 |  |  | 350 |
Other products(1) |  | 3,549 |  |  | 2,021 |  |  | 5,570 |  |  | 3,305 |  |  | 2,016 |  |  | 5,321 |  |  | 3,630 |  |  | 1,744 |  |  | 5,374 |
Total product sales(2) |  | 17,743 |  |  | 7,058 |  |  | 24,801 |  |  | 17,286 |  |  | 7,011 |  |  | 24,297 |  |  | 17,985 |  |  | 6,255 |  |  | 24,240 |
Other revenues |  | 852 |  |  | 670 |  |  | 1,522 |  |  | 908 |  |  | 774 |  |  | 1,682 |  |  | 511 |  |  | 673 |  |  | 1,184 |
Total revenues |  | $ | 18,595 |  |  | $ | 7,728 |  |  | $ | 26,323 |  |  | $ | 18,194 |  |  | $ | 7,785 |  |  | $ | 25,979 |  |  | $ | 18,496 |  |  | $ | 6,928 |  |  | $ | 25,424 |
____________ (1) Consists of product sales of our non-principal products, as well as our Gensenta and Bergamo subsidiaries. (2) Hedging gains and losses, which are included in product sales, were not material for the years ended December 31, 2022, 2021 and 2020. In the United States, we sell primarily to pharmaceutical wholesale distributors that we use as the principal means of distributing our products to healthcare providers. Outside the United States, we sell principally to healthcare providers and/or pharmaceutical wholesale distributors depending on the distribution practice in each country. We monitor the financial condition of our larger customers and limit our credit exposure by setting credit limits and, in certain circumstances, by requiring letters of credit or obtaining credit insurance. We had product sales to three customers that individually accounted for more than 10% of total revenues for each of the years ended December 31, 2022, 2021 and 2020. For the year ended December 31, 2022, on a combined basis, these customers accounted for 82% of total gross revenues as shown in the following table. Certain information with respect to these customers was as follows (dollar amounts in millions):
| Years ended December 31,
| 2022 |  | 2021 |  | 2020
McKesson Corporation: |  |  |  |  |
Gross product sales | $ | 17,305 |  |  | $ | 15,187 |  |  | $ | 13,779 |
% of total gross revenues | 35 | % |  | 33 | % |  | 32 | %
AmerisourceBergen Corporation: |  |  |  |  |
Gross product sales | $ | 15,443 |  |  | $ | 14,783 |  |  | $ | 14,743 |
% of total gross revenues | 31 | % |  | 32 | % |  | 34 | %
Cardinal Health, Inc.: |  |  |  |  |
Gross product sales | $ | 8,319 |  |  | $ | 7,681 |  |  | $ | 7,332 |
% of total gross revenues | 16 | % |  | 17 | % |  | 17 | %
As of December 31, 2022 and 2021, amounts due from these three customers each exceeded 10% of gross trade receivables and accounted for 75% and 73%, respectively, of net trade receivables on a combined basis. As of December 31, 2022 and 2021, 26% and 27%, respectively, of net trade receivables were due from customers located outside the United States, the majority of which were from Europe. Our total allowance for doubtful accounts as of December 31, 2022 and 2021, was not material.

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- Definition The entire disclosure of revenue from contract with customer to transfer good or service and to transfer nonfinancial asset. Includes, but is not limited to, disaggregation of revenue, credit loss recognized from contract with customer, judgment and change in judgment related to contract with customer, and asset recognized from cost incurred to obtain or fulfill contract with customer. Excludes insurance and lease contracts. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -URI https://asc.fasb.org/topic&trid=49130388 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 10 -URI https://asc.fasb.org/extlink&oid=126920106&loc=SL49130551-203045 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 13 -Subparagraph (b)(2) -URI https://asc.fasb.org/extlink&oid=126920106&loc=SL49130556-203045 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 12 -Subparagraph (b) -URI https://asc.fasb.org/extlink&oid=126920106&loc=SL49130554-203045 Reference 5: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 9 -URI https://asc.fasb.org/extlink&oid=126920106&loc=SL49130550-203045 Reference 6: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 12 -Subparagraph (e) -URI https://asc.fasb.org/extlink&oid=126920106&loc=SL49130554-203045 Reference 7: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 12 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126920106&loc=SL49130554-203045 Reference 8: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 12 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=126920106&loc=SL49130554-203045 Reference 9: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 15 -URI https://asc.fasb.org/extlink&oid=126920106&loc=SL49130558-203045 Reference 10: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 12 -Subparagraph (c) -URI https://asc.fasb.org/extlink&oid=126920106&loc=SL49130554-203045 + Details
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