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Revenues (Tables) | 12 Months Ended
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Dec. 31, 2022
Revenue from Contract with Customer [Abstract] |
Disaggregation of revenue by product and by geographic area | Revenues were as follows (in millions):
|  | Year ended December 31, 2022 |  | Year ended December 31, 2021 |  | Year ended December 31, 2020
|  | U.S. |  | ROW |  | Total |  | U.S. |  | ROW |  | Total |  | U.S. |  | ROW |  | Total
ENBREL |  | $ | 4,044 |  |  | $ | 73 |  |  | $ | 4,117 |  |  | $ | 4,352 |  |  | $ | 113 |  |  | $ | 4,465 |  |  | $ | 4,855 |  |  | $ | 141 |  |  | $ | 4,996 |
Prolia |  | 2,465 |  |  | 1,163 |  |  | 3,628 |  |  | 2,150 |  |  | 1,098 |  |  | 3,248 |  |  | 1,830 |  |  | 933 |  |  | 2,763 |
Otezla |  | 1,886 |  |  | 402 |  |  | 2,288 |  |  | 1,804 |  |  | 445 |  |  | 2,249 |  |  | 1,790 |  |  | 405 |  |  | 2,195 |
XGEVA |  | 1,480 |  |  | 534 |  |  | 2,014 |  |  | 1,434 |  |  | 584 |  |  | 2,018 |  |  | 1,405 |  |  | 494 |  |  | 1,899 |
Aranesp |  | 521 |  |  | 900 |  |  | 1,421 |  |  | 537 |  |  | 943 |  |  | 1,480 |  |  | 629 |  |  | 939 |  |  | 1,568 |
Nplate |  | 848 |  |  | 459 |  |  | 1,307 |  |  | 566 |  |  | 461 |  |  | 1,027 |  |  | 485 |  |  | 365 |  |  | 850 |
Repatha |  | 608 |  |  | 688 |  |  | 1,296 |  |  | 557 |  |  | 560 |  |  | 1,117 |  |  | 459 |  |  | 428 |  |  | 887 |
KYPROLIS |  | 850 |  |  | 397 |  |  | 1,247 |  |  | 736 |  |  | 372 |  |  | 1,108 |  |  | 710 |  |  | 355 |  |  | 1,065 |
Neulasta |  | 959 |  |  | 167 |  |  | 1,126 |  |  | 1,514 |  |  | 220 |  |  | 1,734 |  |  | 2,001 |  |  | 292 |  |  | 2,293 |
EVENITY |  | 533 |  |  | 254 |  |  | 787 |  |  | 331 |  |  | 199 |  |  | 530 |  |  | 191 |  |  | 159 |  |  | 350 |
Other products(1) |  | 3,549 |  |  | 2,021 |  |  | 5,570 |  |  | 3,305 |  |  | 2,016 |  |  | 5,321 |  |  | 3,630 |  |  | 1,744 |  |  | 5,374 |
Total product sales(2) |  | 17,743 |  |  | 7,058 |  |  | 24,801 |  |  | 17,286 |  |  | 7,011 |  |  | 24,297 |  |  | 17,985 |  |  | 6,255 |  |  | 24,240 |
Other revenues |  | 852 |  |  | 670 |  |  | 1,522 |  |  | 908 |  |  | 774 |  |  | 1,682 |  |  | 511 |  |  | 673 |  |  | 1,184 |
Total revenues |  | $ | 18,595 |  |  | $ | 7,728 |  |  | $ | 26,323 |  |  | $ | 18,194 |  |  | $ | 7,785 |  |  | $ | 25,979 |  |  | $ | 18,496 |  |  | $ | 6,928 |  |  | $ | 25,424 |
____________ (1) Consists of product sales of our non-principal products, as well as our Gensenta and Bergamo subsidiaries. (2) Hedging gains and losses, which are included in product sales, were not material for the years ended December 31, 2022, 2021 and 2020.
Revenues earned from major customers | Certain information with respect to these customers was as follows (dollar amounts in millions):
| Years ended December 31,
| 2022 |  | 2021 |  | 2020
McKesson Corporation: |  |  |  |  |
Gross product sales | $ | 17,305 |  |  | $ | 15,187 |  |  | $ | 13,779 |
% of total gross revenues | 35 | % |  | 33 | % |  | 32 | %
AmerisourceBergen Corporation: |  |  |  |  |
Gross product sales | $ | 15,443 |  |  | $ | 14,783 |  |  | $ | 14,743 |
% of total gross revenues | 31 | % |  | 32 | % |  | 34 | %
Cardinal Health, Inc.: |  |  |  |  |
Gross product sales | $ | 8,319 |  |  | $ | 7,681 |  |  | $ | 7,332 |
% of total gross revenues | 16 | % |  | 17 | % |  | 17 | %

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