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Acquisitions and divestitures - Summary of Total Consideration for ChemoCentryx Inc (Details) - USD ($) $ in Millions | Dec. 31, 2022 | Oct. 20, 2022 | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | --- | --- | ---
Business Acquisition [Line Items] |  |  |  |
Goodwill | $ 15,529 |  | $ 14,890 | $ 14,689
ChemoCentryx, Inc. |  |  |  |
Business Acquisition [Line Items] |  |  |  |
Cash and cash equivalents |  | $ 86 |  |
Marketable securities |  | 235 |  |
Inventories |  | 41 |  |
Goodwill |  | 667 |  |
Other liabilities, net |  | (85) |  |
Deferred tax liability, net |  | (516) |  |
Total assets acquired, net |  | 3,925 |  |
ChemoCentryx, Inc. | Developed Technology Rights |  |  |  |
Business Acquisition [Line Items] |  |  |  |
Finite-lived intangible assets |  | $ 3,497 |  |

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