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| SUBSIDIARY | | STATE OR OTHER JURISDICTION OF |
| (Name under which subsidiary does business) | | INCORPORATION OR ORGANIZATION |
| | |
| Amgen (Europe) GmbH | | Switzerland |
| Amgen Canada Inc. | | Canada |
| Amgen Fremont Inc. | | Delaware |
| Amgen Global Finance B.V. | | Netherlands |
| Amgen GmbH Germany | | Germany |
| Amgen Ilaç Ticaret Limited Şirketi | | Turkey |
| Amgen K-A, Inc. | | Delaware |
| Amgen Manufacturing, Limited | | Bermuda |
| Amgen Research (Munich) GmbH | | Germany |
| Amgen S.A.S. | | France |
| Amgen S.p.A. | | Italy |
| Amgen SF, LLC | | Delaware |
| Amgen Singapore Manufacturing Pte. Ltd. | | Singapore |
| Amgen Technology (Ireland) Unlimited Company | | Ireland |
| Amgen Technology, Limited | | Bermuda |
| Amgen USA Inc. | | Delaware |
| Amgen Worldwide Holdings B.V. | | Netherlands |
| Amgen, S.A. | | Spain |
| BioVex Limited | | United Kingdom |
| BioVex, Inc. | | Delaware |
| ChemoCentryx, Inc. | | Delaware |
| Five Prime Therapeutics Inc. | | Delaware |
| Immunex Corporation | | Washington |
| Immunex Rhode Island Corporation | | Delaware |
| Onyx Pharmaceuticals, Inc. | | Delaware |
| Onyx Therapeutics, Inc. | | Delaware |
| Saga Investments Coöperatief U.A. | | Netherlands |
| TeneoBio, Inc. | | Delaware |