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Fair value measurement - Narrative (Details) - USD ($)
$ in Millions
Dec. 31, 2022
Dec. 31, 2021
Jan. 02, 2020
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]      
Aggregate fair value of long-term debt, including current portion $ 35,000 $ 37,900  
Carrying value of long-term debt, including current portion 38,945 33,309  
BeiGene      
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]      
Equity Method Investment, Quoted Market Value 4,200 5,100 $ 2,600
Approximate carrying value of the company's equity method investment 2,200 $ 2,800  
Teneobio, Inc.      
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]      
Business Combination, Contingent Consideration Arrangements, Range of Outcomes, Value, High $ 1,600