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Acquisitions and divestitures - Teneobio Inc. (Details) $ in Millions		12 Months Ended
	Dec. 31, 2022 USD ($)	Dec. 31, 2022 USD ($) program	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Business Acquisition [Line Items]
Additions		$ 0	$ 309	$ 0
Goodwill	$ 15,529	15,529	$ 14,890	$ 14,689
Teneobio
Business Acquisition [Line Items]
Goodwill, Purchase Accounting Adjustments		22
Cash purchase price	993
Maximum additional consideration due contingent on certain milestones	1,600	1,600
Additions	299
Deferred tax liabilities	244	244
Goodwill	273	273
Teneobio | R & D Technology rights
Business Acquisition [Line Items]
Finite-lived Intangible Assets Acquired	$ 115
Weighted average period of amortization	10 years
Teneobio | Licensing rights
Business Acquisition [Line Items]
Finite-lived Intangible Assets Acquired	$ 41
Teneobio | IPR&D
Business Acquisition [Line Items]
Acquired in-process research and development	991	$ 991
Number of oncology programs comprising remaining IPR&D | program		4
Teneobio | IPR&D | AMG 340
Business Acquisition [Line Items]
Acquired in-process research and development	$ 784	$ 784

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