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Fair value measurement (Details Textual) - USD ($) $ in Millions | Jun. 30, 2023 | Dec. 31, 2022
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Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Long-term debt, fair value | $ 59,100 | $ 35,000
Carrying value of debt | 61,544 | 38,945
Teneobio Inc. |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Maximum additional consideration due contingent on certain milestones | $ 1,600 | 1,600
BeiGene |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Equity Method Investments,Quoted Market Price |  | 4,200
Carrying value of equity method investment |  | $ 2,200

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