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Revenues - Summary of Revenues (Details) - USD ($)
$ in Millions
 3 Months Ended 6 Months Ended
Jun. 30, 2023
Jun. 30, 2022
Jun. 30, 2023
Jun. 30, 2022
Revenue from External Customer [Line Items]        
Total revenues $ 6,986 $ 6,594 $ 13,091 $ 12,832
Product sales        
Revenue from External Customer [Line Items]        
Total revenues 6,683 6,281 12,529 12,012
Product sales | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 4,736 4,446 8,711 8,483
Product sales | ROW        
Revenue from External Customer [Line Items]        
Total revenues 1,947 1,835 3,818 3,529
Prolia        
Revenue from External Customer [Line Items]        
Total revenues 1,028 922 1,955 1,774
Prolia | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 691 611 1,314 1,193
Prolia | ROW        
Revenue from External Customer [Line Items]        
Total revenues 337 311 641 581
ENBREL        
Revenue from External Customer [Line Items]        
Total revenues 1,068 1,051 1,647 1,913
ENBREL | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 1,055 1,036 1,619 1,879
ENBREL | ROW        
Revenue from External Customer [Line Items]        
Total revenues 13 15 28 34
XGEVA        
Revenue from External Customer [Line Items]        
Total revenues 530 533 1,066 1,035
XGEVA | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 387 391 771 759
XGEVA | ROW        
Revenue from External Customer [Line Items]        
Total revenues 143 142 295 276
Otezla        
Revenue from External Customer [Line Items]        
Total revenues 600 594 992 1,045
Otezla | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 495 487 789 837
Otezla | ROW        
Revenue from External Customer [Line Items]        
Total revenues 105 107 203 208
Repatha        
Revenue from External Customer [Line Items]        
Total revenues 424 325 812 654
Repatha | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 212 154 409 319
Repatha | ROW        
Revenue from External Customer [Line Items]        
Total revenues 212 171 403 335
Aranesp        
Revenue from External Customer [Line Items]        
Total revenues 365 357 720 715
Aranesp | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 123 132 238 269
Aranesp | ROW        
Revenue from External Customer [Line Items]        
Total revenues 242 225 482 446
KYPROLIS        
Revenue from External Customer [Line Items]        
Total revenues 346 317 704 604
KYPROLIS | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 234 213 468 409
KYPROLIS | ROW        
Revenue from External Customer [Line Items]        
Total revenues 112 104 236 195
Nplate        
Revenue from External Customer [Line Items]        
Total revenues 310 284 672 550
Nplate | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 176 156 422 312
Nplate | ROW        
Revenue from External Customer [Line Items]        
Total revenues 134 128 250 238
EVENITY        
Revenue from External Customer [Line Items]        
Total revenues 281 191 535 361
EVENITY | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 192 130 356 240
EVENITY | ROW        
Revenue from External Customer [Line Items]        
Total revenues 89 61 179 121
Other products        
Revenue from External Customer [Line Items]        
Total revenues 1,731 1,707 3,426 3,361
Other products | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 1,171 1,136 2,325 2,266
Other products | ROW        
Revenue from External Customer [Line Items]        
Total revenues 560 571 1,101 1,095
Other revenues        
Revenue from External Customer [Line Items]        
Total revenues $ 303 $ 313 $ 562 $ 820