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Fair value measurement (Details Textual) - USD ($) $ in Millions | 3 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | ---
Sep. 30, 2023 | Sep. 30, 2022 | Sep. 30, 2023 | Sep. 30, 2022 | Dec. 31, 2022 | Oct. 19, 2021
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |  |  |  |
Long-term debt, fair value | $ 56,400 |  | $ 56,400 |  | $ 35,000 |
Carrying value of debt | 60,468 |  | 60,468 |  | 38,945 |
Net changes in valuations | 147 | $ 6 | $ 165 | $ 35 |  |
Teneobio Inc. |  |  |  |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |  |  |  |
Maximum additional consideration due contingent on certain milestones |  |  |  |  |  | $ 1,600
Teneobio Inc. | AMG 340 development program liability |  |  |  |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |  |  |  |
Net changes in valuations | $ 147 |  |  |  |  |
BeiGene |  |  |  |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |  |  |  |
Equity Method Investments,Quoted Market Price |  |  |  |  | 4,200 |
Carrying value of equity method investment |  |  |  |  | $ 2,200 |

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