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Revenues - Summary of Revenues (Details) - USD ($)
$ in Millions
 3 Months Ended 9 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Sep. 30, 2023
Sep. 30, 2022
Revenue from External Customer [Line Items]        
Total revenues $ 6,903 $ 6,652 $ 19,994 $ 19,484
Product sales        
Revenue from External Customer [Line Items]        
Total revenues 6,548 6,237 19,077 18,249
Product sales | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 4,691 4,466 13,402 12,949
Product sales | ROW        
Revenue from External Customer [Line Items]        
Total revenues 1,857 1,771 5,675 5,300
Prolia        
Revenue from External Customer [Line Items]        
Total revenues 986 862 2,941 2,636
Prolia | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 673 590 1,987 1,783
Prolia | ROW        
Revenue from External Customer [Line Items]        
Total revenues 313 272 954 853
ENBREL        
Revenue from External Customer [Line Items]        
Total revenues 1,035 1,106 2,682 3,019
ENBREL | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 1,026 1,086 2,645 2,965
ENBREL | ROW        
Revenue from External Customer [Line Items]        
Total revenues 9 20 37 54
XGEVA        
Revenue from External Customer [Line Items]        
Total revenues 519 495 1,585 1,530
XGEVA | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 374 363 1,145 1,122
XGEVA | ROW        
Revenue from External Customer [Line Items]        
Total revenues 145 132 440 408
Otezla        
Revenue from External Customer [Line Items]        
Total revenues 567 627 1,559 1,672
Otezla | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 462 529 1,251 1,366
Otezla | ROW        
Revenue from External Customer [Line Items]        
Total revenues 105 98 308 306
Repatha        
Revenue from External Customer [Line Items]        
Total revenues 406 309 1,218 963
Repatha | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 183 142 592 461
Repatha | ROW        
Revenue from External Customer [Line Items]        
Total revenues 223 167 626 502
Nplate        
Revenue from External Customer [Line Items]        
Total revenues 419 288 1,091 838
Nplate | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 322 162 744 474
Nplate | ROW        
Revenue from External Customer [Line Items]        
Total revenues 97 126 347 364
KYPROLIS        
Revenue from External Customer [Line Items]        
Total revenues 349 318 1,053 922
KYPROLIS | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 231 217 699 626
KYPROLIS | ROW        
Revenue from External Customer [Line Items]        
Total revenues 118 101 354 296
Aranesp        
Revenue from External Customer [Line Items]        
Total revenues 323 358 1,043 1,073
Aranesp | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 107 128 345 397
Aranesp | ROW        
Revenue from External Customer [Line Items]        
Total revenues 216 230 698 676
EVENITY        
Revenue from External Customer [Line Items]        
Total revenues 307 201 842 562
EVENITY | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 214 136 570 376
EVENITY | ROW        
Revenue from External Customer [Line Items]        
Total revenues 93 65 272 186
Other products        
Revenue from External Customer [Line Items]        
Total revenues 1,637 1,673 5,063 5,034
Other products | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 1,099 1,113 3,424 3,379
Other products | ROW        
Revenue from External Customer [Line Items]        
Total revenues 538 560 1,639 1,655
Other revenues        
Revenue from External Customer [Line Items]        
Total revenues $ 355 $ 415 $ 917 $ 1,235