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Acquisitions and divestitures - Five Prime Therapeutics Inc. (Details) - USD ($) $ in Millions |  | 12 Months Ended
--- | --- | ---
Apr. 16, 2021 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Business Acquisition [Line Items] |  |  |  |
Total cash consideration |  | $ 26,989 | $ 3,839 | $ 2,529
Acquired in-process research and development |  | $ 0 | $ 0 | $ 1,505
Five Prime Therapeutics, Inc. |  |  |  |
Business Acquisition [Line Items] |  |  |  |
Total cash consideration | $ 1,600 |  |  |
Acquired in-process research and development | 1,500 |  |  |
Deferred tax asset | 177 |  |  |
Other liabilities | $ 47 |  |  |

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