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Revenues - Disaggregation of Revenue by Product and by Geographic Area (Details) - USD ($)
$ in Millions
 3 Months Ended 6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Jun. 30, 2024
Jun. 30, 2023
Revenue from External Customer [Line Items]        
Total revenues $ 8,388 $ 6,986 $ 15,835 $ 13,091
Product sales        
Revenue from External Customer [Line Items]        
Total revenues 8,041 6,683 15,159 12,529
Product sales | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 5,840 4,736 10,813 8,711
Product sales | ROW        
Revenue from External Customer [Line Items]        
Total revenues 2,201 1,947 4,346 3,818
Prolia        
Revenue from External Customer [Line Items]        
Total revenues 1,165 1,028 2,164 1,955
Prolia | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 770 691 1,427 1,314
Prolia | ROW        
Revenue from External Customer [Line Items]        
Total revenues 395 337 737 641
ENBREL        
Revenue from External Customer [Line Items]        
Total revenues 909 1,068 1,476 1,647
ENBREL | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 902 1,055 1,463 1,619
ENBREL | ROW        
Revenue from External Customer [Line Items]        
Total revenues 7 13 13 28
XGEVA        
Revenue from External Customer [Line Items]        
Total revenues 562 530 1,123 1,066
XGEVA | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 399 387 765 771
XGEVA | ROW        
Revenue from External Customer [Line Items]        
Total revenues 163 143 358 295
Repatha        
Revenue from External Customer [Line Items]        
Total revenues 532 424 1,049 812
Repatha | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 270 212 543 409
Repatha | ROW        
Revenue from External Customer [Line Items]        
Total revenues 262 212 506 403
Otezla        
Revenue from External Customer [Line Items]        
Total revenues 544 600 938 992
Otezla | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 432 495 725 789
Otezla | ROW        
Revenue from External Customer [Line Items]        
Total revenues 112 105 213 203
TEPEZZA        
Revenue from External Customer [Line Items]        
Total revenues 479 0 903 0
TEPEZZA | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 478 0 897 0
TEPEZZA | ROW        
Revenue from External Customer [Line Items]        
Total revenues 1 0 6 0
KYPROLIS        
Revenue from External Customer [Line Items]        
Total revenues 377 346 753 704
KYPROLIS | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 240 234 474 468
KYPROLIS | ROW        
Revenue from External Customer [Line Items]        
Total revenues 137 112 279 236
EVENITY        
Revenue from External Customer [Line Items]        
Total revenues 391 281 733 535
EVENITY | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 281 192 517 356
EVENITY | ROW        
Revenue from External Customer [Line Items]        
Total revenues 110 89 216 179
Aranesp        
Revenue from External Customer [Line Items]        
Total revenues 348 365 697 720
Aranesp | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 91 123 191 238
Aranesp | ROW        
Revenue from External Customer [Line Items]        
Total revenues 257 242 506 482
Nplate        
Revenue from External Customer [Line Items]        
Total revenues 346 310 663 672
Nplate | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 214 176 404 422
Nplate | ROW        
Revenue from External Customer [Line Items]        
Total revenues 132 134 259 250
KRYSTEXXA        
Revenue from External Customer [Line Items]        
Total revenues 294 0 529 0
KRYSTEXXA | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 294 0 529 0
KRYSTEXXA | ROW        
Revenue from External Customer [Line Items]        
Total revenues 0 0 0 0
Vectibix        
Revenue from External Customer [Line Items]        
Total revenues 270 248 517 481
Vectibix | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 133 118 253 229
Vectibix | ROW        
Revenue from External Customer [Line Items]        
Total revenues 137 130 264 252
BLINCYTO        
Revenue from External Customer [Line Items]        
Total revenues 264 206 508 400
BLINCYTO | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 165 145 318 271
BLINCYTO | ROW        
Revenue from External Customer [Line Items]        
Total revenues 99 61 190 129
TEZSPIRE        
Revenue from External Customer [Line Items]        
Total revenues 234 133 407 229
TEZSPIRE | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 234 133 407 229
TEZSPIRE | ROW        
Revenue from External Customer [Line Items]        
Total revenues 0 0 0 0
Other products        
Revenue from External Customer [Line Items]        
Total revenues 1,326 1,144 2,699 2,316
Other products | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 937 775 1,900 1,596
Other products | ROW        
Revenue from External Customer [Line Items]        
Total revenues 389 369 799 720
Other revenues        
Revenue from External Customer [Line Items]        
Total revenues $ 347 $ 303 $ 676 $ 562