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Revenues - Disaggregation of Revenue by Product and by Geographic Area (Details) - USD ($)
$ in Millions
 3 Months Ended 9 Months Ended
Sep. 30, 2024
Sep. 30, 2023
Sep. 30, 2024
Sep. 30, 2023
Revenue from External Customer [Line Items]        
Total revenues $ 8,503 $ 6,903 $ 24,338 $ 19,994
Product sales        
Revenue from External Customer [Line Items]        
Total revenues 8,151 6,548 23,310 19,077
Product sales | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 5,979 4,691 16,792 13,402
Product sales | ROW        
Revenue from External Customer [Line Items]        
Total revenues 2,172 1,857 6,518 5,675
Prolia        
Revenue from External Customer [Line Items]        
Total revenues 1,045 986 3,209 2,941
Prolia | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 683 673 2,110 1,987
Prolia | ROW        
Revenue from External Customer [Line Items]        
Total revenues 362 313 1,099 954
ENBREL        
Revenue from External Customer [Line Items]        
Total revenues 825 1,035 2,301 2,682
ENBREL | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 817 1,026 2,280 2,645
ENBREL | ROW        
Revenue from External Customer [Line Items]        
Total revenues 8 9 21 37
XGEVA        
Revenue from External Customer [Line Items]        
Total revenues 541 519 1,664 1,585
XGEVA | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 373 374 1,138 1,145
XGEVA | ROW        
Revenue from External Customer [Line Items]        
Total revenues 168 145 526 440
Repatha        
Revenue from External Customer [Line Items]        
Total revenues 567 406 1,616 1,218
Repatha | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 281 183 824 592
Repatha | ROW        
Revenue from External Customer [Line Items]        
Total revenues 286 223 792 626
Otezla        
Revenue from External Customer [Line Items]        
Total revenues 564 567 1,502 1,559
Otezla | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 460 462 1,185 1,251
Otezla | ROW        
Revenue from External Customer [Line Items]        
Total revenues 104 105 317 308
TEPEZZA        
Revenue from External Customer [Line Items]        
Total revenues 488 0 1,391 0
TEPEZZA | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 482 0 1,379 0
TEPEZZA | ROW        
Revenue from External Customer [Line Items]        
Total revenues 6 0 12 0
EVENITY        
Revenue from External Customer [Line Items]        
Total revenues 399 307 1,132 842
EVENITY | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 289 214 806 570
EVENITY | ROW        
Revenue from External Customer [Line Items]        
Total revenues 110 93 326 272
KYPROLIS        
Revenue from External Customer [Line Items]        
Total revenues 378 349 1,131 1,053
KYPROLIS | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 238 231 712 699
KYPROLIS | ROW        
Revenue from External Customer [Line Items]        
Total revenues 140 118 419 354
Nplate        
Revenue from External Customer [Line Items]        
Total revenues 456 419 1,119 1,091
Nplate | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 345 322 749 744
Nplate | ROW        
Revenue from External Customer [Line Items]        
Total revenues 111 97 370 347
Aranesp        
Revenue from External Customer [Line Items]        
Total revenues 337 323 1,034 1,043
Aranesp | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 105 107 296 345
Aranesp | ROW        
Revenue from External Customer [Line Items]        
Total revenues 232 216 738 698
KRYSTEXXA        
Revenue from External Customer [Line Items]        
Total revenues 310 0 839 0
KRYSTEXXA | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 310 0 839 0
KRYSTEXXA | ROW        
Revenue from External Customer [Line Items]        
Total revenues 0 0 0 0
BLINCYTO        
Revenue from External Customer [Line Items]        
Total revenues 327 220 835 620
BLINCYTO | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 237 147 555 418
BLINCYTO | ROW        
Revenue from External Customer [Line Items]        
Total revenues 90 73 280 202
Vectibix        
Revenue from External Customer [Line Items]        
Total revenues 282 252 799 733
Vectibix | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 132 116 385 345
Vectibix | ROW        
Revenue from External Customer [Line Items]        
Total revenues 150 136 414 388
TEZSPIRE        
Revenue from External Customer [Line Items]        
Total revenues 269 161 676 390
TEZSPIRE | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 269 161 676 390
TEZSPIRE | ROW        
Revenue from External Customer [Line Items]        
Total revenues 0 0 0 0
Other products        
Revenue from External Customer [Line Items]        
Total revenues 1,363 1,004 4,062 3,320
Other products | U.S.        
Revenue from External Customer [Line Items]        
Total revenues 958 675 2,858 2,271
Other products | ROW        
Revenue from External Customer [Line Items]        
Total revenues 405 329 1,204 1,049
Other revenues        
Revenue from External Customer [Line Items]        
Total revenues $ 352 $ 355 $ 1,028 $ 917