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Acquisitions and divestitures - Schedule of Total Consideration for ChemoCentryx Inc (Details) - USD ($) $ in Millions | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Oct. 20, 2022
--- | --- | --- | --- | ---
Business Acquisition [Line Items] |  |  |  |
Goodwill | $ 18,637 | $ 18,629 | $ 15,529 |
ChemoCentryx, Inc. |  |  |  |
Business Acquisition [Line Items] |  |  |  |
Cash and cash equivalents |  |  |  | $ 86
Marketable securities |  |  |  | 235
Inventories |  |  |  | 41
Goodwill |  |  |  | 649
Other liabilities, net |  |  |  | (83)
Deferred tax liability, net |  |  |  | (502)
Total assets acquired, net of liabilities assumed |  |  |  | 3,925
ChemoCentryx, Inc. | Developed-product-technology rights |  |  |  |
Business Acquisition [Line Items] |  |  |  |
Finite-lived intangible assets—developed-product-technology rights |  |  |  | $ 3,499

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