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Revenues - Schedule of Disaggregation of Revenue by Product and by Geographic Area (Details) - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | $ 33,424 | $ 28,190 | $ 26,323
U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 23,863 | 19,806 | 18,595
ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 9,561 | 8,384 | 7,728
Prolia |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 4,374 | 4,048 | 3,628
Prolia | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 2,885 | 2,733 | 2,465
Prolia | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,489 | 1,315 | 1,163
ENBREL |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 3,316 | 3,697 | 4,117
ENBREL | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 3,288 | 3,650 | 4,044
ENBREL | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 28 | 47 | 73
XGEVA |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 2,225 | 2,112 | 2,014
XGEVA | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,507 | 1,527 | 1,480
XGEVA | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 718 | 585 | 534
Repatha |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 2,222 | 1,635 | 1,296
Repatha | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,139 | 793 | 608
Repatha | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,083 | 842 | 688
Otezla |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 2,126 | 2,188 | 2,288
Otezla | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,699 | 1,777 | 1,886
Otezla | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 427 | 411 | 402
TEPEZZA |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,851 | 448 | 0
TEPEZZA | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,835 | 441 | 0
TEPEZZA | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 16 | 7 | 0
EVENITY |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,563 | 1,160 | 787
EVENITY | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,131 | 809 | 533
EVENITY | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 432 | 351 | 254
KYPROLIS |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,503 | 1,403 | 1,247
KYPROLIS | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 948 | 921 | 850
KYPROLIS | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 555 | 482 | 397
Nplate |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,456 | 1,477 | 1,307
Nplate | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 970 | 996 | 848
Nplate | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 486 | 481 | 459
Aranesp |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,342 | 1,362 | 1,421
Aranesp | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 386 | 452 | 521
Aranesp | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 956 | 910 | 900
BLINCYTO |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,216 | 861 | 583
BLINCYTO | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 800 | 566 | 336
BLINCYTO | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 416 | 295 | 247
KRYSTEXXA |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,185 | 272 | 0
KRYSTEXXA | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,185 | 272 | 0
KRYSTEXXA | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 0 | 0 | 0
Vectibix |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,045 | 984 | 893
Vectibix | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 519 | 461 | 396
Vectibix | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 526 | 523 | 497
TEZSPIRE |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 972 | 567 | 170
TEZSPIRE | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 972 | 567 | 170
TEZSPIRE | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 0 | 0 | 0
Other products |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 5,630 | 4,696 | 5,050
Other products | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 4,037 | 3,307 | 3,606
Other products | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,593 | 1,389 | 1,444
Product sales |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 32,026 | 26,910 | 24,801
Product sales | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 23,301 | 19,272 | 17,743
Product sales | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 8,725 | 7,638 | 7,058
Other revenues |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 1,398 | 1,280 | 1,522
Other revenues | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | 562 | 534 | 852
Other revenues | ROW |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Total revenues | $ 836 | $ 746 | $ 670

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