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Revenues - Schedule of Disaggregation of Revenue by Product and by Geographic Area (Details) - USD ($)
$ in Millions
 3 Months Ended
Mar. 31, 2025
Mar. 31, 2024
Disaggregation of Revenue [Line Items]    
Total revenues $ 8,149 $ 7,447
Product sales    
Disaggregation of Revenue [Line Items]    
Total revenues 7,873 7,118
Product sales | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 5,662 4,973
Product sales | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 2,211 2,145
Prolia    
Disaggregation of Revenue [Line Items]    
Total revenues 1,099 999
Prolia | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 720 657
Prolia | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 379 342
Repatha    
Disaggregation of Revenue [Line Items]    
Total revenues 656 517
Repatha | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 343 273
Repatha | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 313 244
XGEVA    
Disaggregation of Revenue [Line Items]    
Total revenues 566 561
XGEVA | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 360 366
XGEVA | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 206 195
ENBREL    
Disaggregation of Revenue [Line Items]    
Total revenues 510 567
ENBREL | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 504 561
ENBREL | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 6 6
EVENITY    
Disaggregation of Revenue [Line Items]    
Total revenues 442 342
EVENITY | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 320 236
EVENITY | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 122 106
Otezla    
Disaggregation of Revenue [Line Items]    
Total revenues 437 394
Otezla | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 343 293
Otezla | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 94 101
TEPEZZA    
Disaggregation of Revenue [Line Items]    
Total revenues 381 424
TEPEZZA | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 365 419
TEPEZZA | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 16 5
BLINCYTO    
Disaggregation of Revenue [Line Items]    
Total revenues 370 244
BLINCYTO | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 273 153
BLINCYTO | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 97 91
Aranesp    
Disaggregation of Revenue [Line Items]    
Total revenues 340 349
Aranesp | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 91 100
Aranesp | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 249 249
KYPROLIS    
Disaggregation of Revenue [Line Items]    
Total revenues 324 376
KYPROLIS | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 216 234
KYPROLIS | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 108 142
Nplate    
Disaggregation of Revenue [Line Items]    
Total revenues 313 317
Nplate | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 201 190
Nplate | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 112 127
TEZSPIRE    
Disaggregation of Revenue [Line Items]    
Total revenues 285 173
TEZSPIRE | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 285 173
TEZSPIRE | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 0 0
Vectibix    
Disaggregation of Revenue [Line Items]    
Total revenues 267 247
Vectibix | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 135 120
Vectibix | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 132 127
KRYSTEXXA    
Disaggregation of Revenue [Line Items]    
Total revenues 236 235
KRYSTEXXA | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 236 235
KRYSTEXXA | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 0 0
Other products    
Disaggregation of Revenue [Line Items]    
Total revenues 1,647 1,373
Other products | U.S.    
Disaggregation of Revenue [Line Items]    
Total revenues 1,270 963
Other products | ROW    
Disaggregation of Revenue [Line Items]    
Total revenues 377 410
Other revenues    
Disaggregation of Revenue [Line Items]    
Total revenues $ 276 $ 329