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Revenues - Schedule of Disaggregation of Revenue by Product and by Geographic Area (Details) - USD ($) $ in Millions | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2025 | Sep. 30, 2024 | Sep. 30, 2025 | Sep. 30, 2024
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | $ 9,557 | $ 8,503 | $ 26,885 | $ 24,338
Product sales |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 9,137 | 8,151 | 25,781 | 23,310
Product sales | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 6,751 | 5,979 | 18,737 | 16,792
Product sales | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 2,386 | 2,172 | 7,044 | 6,518
Prolia |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 1,139 | 1,045 | 3,360 | 3,209
Prolia | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 806 | 683 | 2,271 | 2,110
Prolia | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 333 | 362 | 1,089 | 1,099
Repatha |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 794 | 567 | 2,146 | 1,616
Repatha | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 442 | 281 | 1,146 | 824
Repatha | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 352 | 286 | 1,000 | 792
ENBREL |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 580 | 825 | 1,694 | 2,301
ENBREL | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 574 | 817 | 1,675 | 2,280
ENBREL | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 6 | 8 | 19 | 21
Otezla |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 585 | 564 | 1,640 | 1,502
Otezla | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 473 | 460 | 1,328 | 1,185
Otezla | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 112 | 104 | 312 | 317
XGEVA |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 539 | 541 | 1,637 | 1,664
XGEVA | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 357 | 373 | 1,064 | 1,138
XGEVA | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 182 | 168 | 573 | 526
EVENITY |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 541 | 399 | 1,501 | 1,132
EVENITY | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 417 | 289 | 1,132 | 806
EVENITY | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 124 | 110 | 369 | 326
TEPEZZA |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 560 | 488 | 1,446 | 1,391
TEPEZZA | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 518 | 482 | 1,349 | 1,379
TEPEZZA | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 42 | 6 | 97 | 12
BLINCYTO |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 392 | 327 | 1,146 | 835
BLINCYTO | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 236 | 237 | 779 | 555
BLINCYTO | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 156 | 90 | 367 | 280
Nplate |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 457 | 456 | 1,139 | 1,119
Nplate | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 333 | 345 | 762 | 749
Nplate | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 124 | 111 | 377 | 370
KYPROLIS |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 359 | 378 | 1,061 | 1,131
KYPROLIS | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 225 | 238 | 673 | 712
KYPROLIS | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 134 | 140 | 388 | 419
Aranesp |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 357 | 337 | 1,056 | 1,034
Aranesp | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 103 | 105 | 301 | 296
Aranesp | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 254 | 232 | 755 | 738
TEZSPIRE |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 377 | 269 | 1,004 | 676
TEZSPIRE | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 377 | 269 | 1,004 | 676
TEZSPIRE | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 0 | 0 | 0 | 0
KRYSTEXXA |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 320 | 310 | 905 | 839
KRYSTEXXA | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 320 | 310 | 905 | 839
KRYSTEXXA | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 0 | 0 | 0 | 0
Vectibix |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 284 | 282 | 856 | 799
Vectibix | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 162 | 132 | 441 | 385
Vectibix | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 122 | 150 | 415 | 414
Other products |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 1,853 | 1,363 | 5,190 | 4,062
Other products | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 1,408 | 958 | 3,907 | 2,858
Other products | ROW |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | 445 | 405 | 1,283 | 1,204
Other revenues |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total revenues | $ 420 | $ 352 | $ 1,104 | $ 1,028

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