XML 49 R38.htm IDEA: XBRL DOCUMENT v3.25.3
Revenues - Schedule of Disaggregation of Revenue by Product and by Geographic Area (Details) - USD ($)
$ in Millions
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Disaggregation of Revenue [Line Items]        
Total revenues $ 9,557 $ 8,503 $ 26,885 $ 24,338
Product sales        
Disaggregation of Revenue [Line Items]        
Total revenues 9,137 8,151 25,781 23,310
Product sales | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 6,751 5,979 18,737 16,792
Product sales | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 2,386 2,172 7,044 6,518
Prolia        
Disaggregation of Revenue [Line Items]        
Total revenues 1,139 1,045 3,360 3,209
Prolia | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 806 683 2,271 2,110
Prolia | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 333 362 1,089 1,099
Repatha        
Disaggregation of Revenue [Line Items]        
Total revenues 794 567 2,146 1,616
Repatha | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 442 281 1,146 824
Repatha | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 352 286 1,000 792
ENBREL        
Disaggregation of Revenue [Line Items]        
Total revenues 580 825 1,694 2,301
ENBREL | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 574 817 1,675 2,280
ENBREL | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 6 8 19 21
Otezla        
Disaggregation of Revenue [Line Items]        
Total revenues 585 564 1,640 1,502
Otezla | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 473 460 1,328 1,185
Otezla | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 112 104 312 317
XGEVA        
Disaggregation of Revenue [Line Items]        
Total revenues 539 541 1,637 1,664
XGEVA | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 357 373 1,064 1,138
XGEVA | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 182 168 573 526
EVENITY        
Disaggregation of Revenue [Line Items]        
Total revenues 541 399 1,501 1,132
EVENITY | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 417 289 1,132 806
EVENITY | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 124 110 369 326
TEPEZZA        
Disaggregation of Revenue [Line Items]        
Total revenues 560 488 1,446 1,391
TEPEZZA | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 518 482 1,349 1,379
TEPEZZA | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 42 6 97 12
BLINCYTO        
Disaggregation of Revenue [Line Items]        
Total revenues 392 327 1,146 835
BLINCYTO | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 236 237 779 555
BLINCYTO | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 156 90 367 280
Nplate        
Disaggregation of Revenue [Line Items]        
Total revenues 457 456 1,139 1,119
Nplate | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 333 345 762 749
Nplate | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 124 111 377 370
KYPROLIS        
Disaggregation of Revenue [Line Items]        
Total revenues 359 378 1,061 1,131
KYPROLIS | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 225 238 673 712
KYPROLIS | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 134 140 388 419
Aranesp        
Disaggregation of Revenue [Line Items]        
Total revenues 357 337 1,056 1,034
Aranesp | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 103 105 301 296
Aranesp | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 254 232 755 738
TEZSPIRE        
Disaggregation of Revenue [Line Items]        
Total revenues 377 269 1,004 676
TEZSPIRE | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 377 269 1,004 676
TEZSPIRE | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 0 0 0 0
KRYSTEXXA        
Disaggregation of Revenue [Line Items]        
Total revenues 320 310 905 839
KRYSTEXXA | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 320 310 905 839
KRYSTEXXA | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 0 0 0 0
Vectibix        
Disaggregation of Revenue [Line Items]        
Total revenues 284 282 856 799
Vectibix | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 162 132 441 385
Vectibix | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 122 150 415 414
Other products        
Disaggregation of Revenue [Line Items]        
Total revenues 1,853 1,363 5,190 4,062
Other products | U.S.        
Disaggregation of Revenue [Line Items]        
Total revenues 1,408 958 3,907 2,858
Other products | ROW        
Disaggregation of Revenue [Line Items]        
Total revenues 445 405 1,283 1,204
Other revenues        
Disaggregation of Revenue [Line Items]        
Total revenues $ 420 $ 352 $ 1,104 $ 1,028