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  <xs:element id="bsx_ProductLiabilityCasesOrClaimsRelatedToMeshProductAustralia" abstract="false" name="ProductLiabilityCasesOrClaimsRelatedToMeshProductAustralia" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="bsx_RhythmandNeuroMember" abstract="true" name="RhythmandNeuroMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="bsx_ScheduleofIncomeTaxRateReconciliationTable" abstract="true" name="ScheduleofIncomeTaxRateReconciliationTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="bsx_CashCashEquivalentsRestrictedCashandRestrictedCashEquivalentsLineItems" abstract="true" name="CashCashEquivalentsRestrictedCashandRestrictedCashEquivalentsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
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  <xs:element id="bsx_LicensingArrangementsAssetPercentageOfFutureRoyaltyPaymentsSold" abstract="false" name="LicensingArrangementsAssetPercentageOfFutureRoyaltyPaymentsSold" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="bsx_RequirementthirdquarterfollowingqualifiedacquisitionMember" abstract="true" name="RequirementthirdquarterfollowingqualifiedacquisitionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="bsx_December2027NotesMember" abstract="true" name="December2027NotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="bsx_IntangibleAssetsandGoodwillLineItems" abstract="true" name="IntangibleAssetsandGoodwillLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="bsx_LicensingarrangementassetsMember" abstract="true" name="LicensingarrangementassetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="bsx_CondensedConsolidatedCashFlowSupplementalDIsclosureAbstract" abstract="true" name="CondensedConsolidatedCashFlowSupplementalDIsclosureAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="bsx_October2023NotesMember" abstract="true" name="October2023NotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
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  <xs:element id="bsx_NewAccountingPronouncementsPolicyTextBlock" abstract="false" name="NewAccountingPronouncementsPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="bsx_RevenueBasedPaymentsMember" abstract="true" name="RevenueBasedPaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="bsx_March2026NotesMember" abstract="true" name="March2026NotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="bsx_ProductLiabilityCasesRelatedToGreenfieldVenaCavaFilter" abstract="false" name="ProductLiabilityCasesRelatedToGreenfieldVenaCavaFilter" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="bsx_StockIssuedDuringPeriodValueNewIssuesCommonStock" abstract="false" name="StockIssuedDuringPeriodValueNewIssuesCommonStock" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="bsx_FarapulseMember" abstract="true" name="FarapulseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="bsx_ASCUpdateNo202105LeasesTopic842LessorsCertainLeasesWithVariableLeasePaymentsTextBlock" abstract="false" name="ASCUpdateNo202105LeasesTopic842LessorsCertainLeasesWithVariableLeasePaymentsTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="bsx_March2039NotesMember" abstract="true" name="March2039NotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="bsx_RevolvingCreditFacility2021Member" abstract="true" name="RevolvingCreditFacility2021Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="bsx_CurrentRequirementMember" abstract="true" name="CurrentRequirementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="bsx_May2025NotesMember" abstract="true" name="May2025NotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="bsx_Licensingarrangementsliability" abstract="false" name="Licensingarrangementsliability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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</xs:schema>
