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  <xs:element id="bsx_March2034NotesMember" abstract="true" name="March2034NotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_TheOfferingAggregatePrincipalAmountMember" abstract="true" name="TheOfferingAggregatePrincipalAmountMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_March2025NotesMember" abstract="true" name="March2025NotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_TheOfferingEarlyRedemptionOfCombinedAggregatePrincipalSNMember" abstract="true" name="TheOfferingEarlyRedemptionOfCombinedAggregatePrincipalSNMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
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  <xs:element id="bsx_RequirementAsOfMarch312021Member" abstract="true" name="RequirementAsOfMarch312021Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_RequirementAsOfDecember312024AndThroughRemainingTermOfFacilityMember" abstract="true" name="RequirementAsOfDecember312024AndThroughRemainingTermOfFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
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  <xs:element id="bsx_DeferredTaxAssetsAndPrepaidOnIntercompanyProfit" abstract="false" name="DeferredTaxAssetsAndPrepaidOnIntercompanyProfit" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="bsx_CompensationExpensePerShareDiluted" abstract="false" name="CompensationExpensePerShareDiluted" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
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  <xs:element id="bsx_SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsExpectedtoVestOutstandingAggregateIntrinsicValue" abstract="false" name="SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsExpectedtoVestOutstandingAggregateIntrinsicValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="bsx_AmountOfEmployeesTotalCompensationEligibleForGesopPurchase" abstract="false" name="AmountOfEmployeesTotalCompensationEligibleForGesopPurchase" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
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  <xs:element id="bsx_TargetPayoutOfFreeCashFlowsFcfPerformanceAwards" abstract="false" name="TargetPayoutOfFreeCashFlowsFcfPerformanceAwards" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
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  <xs:element id="bsx_OperatingIncomeLossAdjustedPercentageOfNetSales" abstract="false" name="OperatingIncomeLossAdjustedPercentageOfNetSales" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
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  <xs:element id="bsx_GlobalUrologyandPelvicHealthReportingUnitMember" abstract="true" name="GlobalUrologyandPelvicHealthReportingUnitMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_GlobalNeuromodulationNmReportingUnitMember" abstract="true" name="GlobalNeuromodulationNmReportingUnitMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_GlobalPeripheralInterventionsPiReportingUnitMember" abstract="true" name="GlobalPeripheralInterventionsPiReportingUnitMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_InterventionalCardiologyTherapiesMember" abstract="true" name="InterventionalCardiologyTherapiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_CardiacRhythmManagementMember" abstract="true" name="CardiacRhythmManagementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_ElectrophysiologyEPMember" abstract="true" name="ElectrophysiologyEPMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_WatchmanMember" abstract="true" name="WatchmanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_GlobalCardiologyReportingUnitMember" abstract="true" name="GlobalCardiologyReportingUnitMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_OtherMember" abstract="true" name="OtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_LatinAmericaandCanadaMember" abstract="true" name="LatinAmericaandCanadaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_EmergingMarketsMember" abstract="true" name="EmergingMarketsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_USExcludingOtherNetSalesMember" abstract="true" name="USExcludingOtherNetSalesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_ExecutiveRetirementPlanMember" abstract="true" name="ExecutiveRetirementPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_InternationalRetirementPlansMember" abstract="true" name="InternationalRetirementPlansMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_OtherInternationalPlansMember" abstract="true" name="OtherInternationalPlansMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="bsx_Pensionbenefitobligationbenefitspaid" abstract="false" name="Pensionbenefitobligationbenefitspaid" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="bsx_DefinedBenefitPlanPlanAssetsPaymentForSettlementPBO" abstract="false" name="DefinedBenefitPlanPlanAssetsPaymentForSettlementPBO" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="bsx_DefinedBenefitPlanPlanAssetsActuarialGainLoss" abstract="false" name="DefinedBenefitPlanPlanAssetsActuarialGainLoss" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="bsx_DefinedBenefitPlanPlanAssetsAssumptionsusedtoDetermineExpectedReturn" abstract="false" name="DefinedBenefitPlanPlanAssetsAssumptionsusedtoDetermineExpectedReturn" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="bsx_ExpenseRelatedToMatchingContributions" abstract="false" name="ExpenseRelatedToMatchingContributions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="bsx_EllenZaneMember" abstract="true" name="EllenZaneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bsx_MichaelF.MahoneyMember" abstract="true" name="MichaelF.MahoneyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bsx_RuleTradingArrangementCommonStockMember" abstract="true" name="RuleTradingArrangementCommonStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bsx_RuleTradingArrangementStockStockOptionsMember" abstract="true" name="RuleTradingArrangementStockStockOptionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bsx_VanceR.BrownMember" abstract="true" name="VanceR.BrownMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bsx_JeffreyB.MirvissMember" abstract="true" name="JeffreyB.MirvissMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bsx_RuleTradingArrangementPerformanceAndRestrictedShareUnitsMember" abstract="true" name="RuleTradingArrangementPerformanceAndRestrictedShareUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bsx_EmilyM.WoodworthMember" abstract="true" name="EmilyM.WoodworthMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
